ArticleCell metabolism2017
A Stat6/Pten Axis Links Regulatory T Cells with Adipose Tissue Function.
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Article in Cell metabolism, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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62citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
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Who cites it
62 citing papers in PubMed, 96 citations in OpenAlex.
- Regulatory T cells establish an IL-10-IL10Rα immunometabolic checkpoint that limits HSL activation and lipolysis.bioRxiv : the preprint server for biology · 2026Article
- GPSM1 restricts CD73Nature communications · 2026Article
- Subcutaneous White Adipose Tissue Derived from Female Mice Achieves Better Graft Outcomes Through the Involvement of Tregs.Aesthetic plastic surgery · 2026Article
- Modulating Th17/Treg Balance in Alzheimer's Disease: Therapeutic Insights from Natural Compounds and Immunometabolism.Brain sciences · 2026Review
- The role of immune responses and microbiota in adipose tissue homeostasis.The Journal of physiology · 2025Review
- Neuro-immune Interactions in Metabolic Regulation: Brain and Adipose Tissue Crosstalk.Journal of obesity & metabolic syndrome · 2025Review
- Regulatory T cells in brown adipose tissue safeguard thermogenesis by restraining interferon-γ-producing lymphocytes.Science immunology · 2025Article
- The brainstem reticular formation pivots abnormal neural transmission in the course of Anorexia Nervosa.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Regulatory T cells in the mouse hypothalamus control immune activation and ameliorate metabolic impairments in high-calorie environments.Nature communications · 2025Article
- Transcriptomic signatures of cold acclimated adipocytes reveal CXCL12 as a Brown autocrine and paracrine chemokine.Molecular metabolism · 2025Article
- Immune Regulatory Crosstalk in Adipose Tissue Thermogenesis.Comprehensive Physiology · 2025Review
- Association of the lymphocyte-to-C-reactive protein ratio with long-term mortality in hospitalized older adults with severe dysphagia.Frontiers in nutrition · 2025Article
- The Impact of Cell-Intrinsic STAT6 Protein on Donor T Cell-Mediated Graft-Versus-Tumor Effect.International journal of molecular sciences · 2024Article
- Adipocyte FGF21 Signaling Defect Aggravated Adipose Tissue Inflammation in Gestational Diabetes Mellitus.Nutrients · 2024Article
- Lack of p38 activation in T cells increases IL-35 and protects against obesity by promoting thermogenesis.EMBO reports · 2024Article
- mTORC1 in energy expenditure: consequences for obesity.Nature reviews. Endocrinology · 2024Review
- Dynamic changes of immunocyte subpopulations in thermogenic activation of adipose tissues.Frontiers in immunology · 2024Article
- Regulatory T cells require IL6 receptor alpha signaling to control skeletal muscle function and regeneration.Cell metabolism · 2023Article
- Adipose tissue aging is regulated by an altered immune system.Frontiers in immunology · 2023Review
- Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation.Nature communications · 2022Article
2 more citing papers are in PubMed but not listed here.
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Authors and funding
30 authors at 16 institutions in 4 countries.
Stefanie KälinInstitute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München and Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 85748 Munich, Germany; German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany.
Maike BeckerGerman Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany; Institute for Diabetes Research, Research Group Immune Tolerance in Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939 Munich, Germany.
Verena B OttInstitute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München and Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 85748 Munich, Germany; German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany; Institute for Advanced Study, Technische Universität München, 85748 Garching, Germany.
Isabelle SerrGerman Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany; Institute for Diabetes Research, Research Group Immune Tolerance in Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939 Munich, Germany.
Fabian HospMax Planck Institute of Biochemistry, 82152 Martinsried, Germany.
Mohammad M H MollahGerman Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany; Institute for Diabetes Research, Research Group Immune Tolerance in Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939 Munich, Germany.
Susanne KeipertInstitute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München and Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 85748 Munich, Germany; German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany.
Daniel LampInstitute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München and Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 85748 Munich, Germany; German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany.
Francoise Rohner-JeanrenaudLaboratory of Metabolism, Division of Endocrinology, Diabetology, Hypertension, and Nutrition, Department of Internal Medicine Specialties, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Victoria K FlynnGerman Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany; Institute for Diabetes Research, Research Group Immune Tolerance in Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939 Munich, Germany.
Martin G SchermGerman Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany; Institute for Diabetes Research, Research Group Immune Tolerance in Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939 Munich, Germany.
Lucas F R NascimentoGerman Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany; Institute for Diabetes Research, Research Group Immune Tolerance in Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939 Munich, Germany.
Katharina GerlachDepartment of Medicine 1, University of Erlangen-Nuremberg, 91052 Erlangen, Germany.
Vanessa PoppDepartment of Medicine 1, University of Erlangen-Nuremberg, 91052 Erlangen, Germany.
Sarah DietzenInstitute of Immunology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
Tobias BoppInstitute of Immunology, University Medical Center of the Johannes Gutenberg University, 55131 Mainz, Germany.
Purna KrishnamurthyDepartment of Pediatrics and HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Mark H KaplanDepartment of Pediatrics and HB Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Manuel SerranoTumour Suppression Group, Spanish National Cancer Research Centre (CNIO), 28029 Madrid, Spain.
Stephen C WoodsDepartment of Psychiatry and Behavioral Neuroscience, University of Cincinnati, Cincinnati, OH, USA.
Philipp TripalOICE (Optical Imaging Centre Erlangen), University Erlangen, 91052 Erlangen, Germany.
Ralf PalmisanoOICE (Optical Imaging Centre Erlangen), University Erlangen, 91052 Erlangen, Germany.
Martin JastrochInstitute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München and Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 85748 Munich, Germany; German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany.
Matthias BlüherDepartment of Medicine, Research Group Molecular Endocrinology, University of Leipzig, 04103 Leipzig, Germany.
Christian WolfrumSwiss Federal Institute of Technology, Institute of Food Nutrition and Health, Laboratory of Translational Nutrition Biology, ETH Zurich, 8603 Schwerzenbach, Switzerland.
Benno WeigmannDepartment of Medicine 1, University of Erlangen-Nuremberg, 91052 Erlangen, Germany.
Anette-Gabriele ZieglerGerman Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany; Institute for Diabetes Research, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939 Munich, Germany; Klinikum rechts der Isar, Technische Universität München, 80333 Munich, Germany.
Matthias MannMax Planck Institute of Biochemistry, 82152 Martinsried, Germany.
Matthias H TschöpInstitute for Diabetes and Obesity, Helmholtz Diabetes Center at Helmholtz Zentrum München and Division of Metabolic Diseases, Department of Medicine, Technische Universität München, 85748 Munich, Germany; German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany. Electronic address: tschoep@helmholtz-muenchen.de.
Carolin DanielInstitute for Diabetes Research, Research Group Immune Tolerance in Diabetes, Helmholtz Diabetes Center at Helmholtz Zentrum München, 80939 Munich, Germany; German Center for Diabetes Research (DZD), 85764 Munich-Neuherberg, Germany. Electronic address: carolin.daniel@helmholtz-muenchen.de.
Deutsches Diabetes-Zentrum e.V. · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DEGerman Center for Diabetes Research · DEHelmholtz Zentrum München · DEHeinrich Heine University Düsseldorf · DEMax Planck Institute of Biochemistry · DEUniversity Medical Center of the Johannes Gutenberg University Mainz · DEETH Zurich · CHIndiana University – Purdue University Indianapolis · USIndiana University School of MedicineInstitute for Advanced Study · DELeipzig University · DESpanish National Cancer Research Centre · ESTechnical University of Munich · DEUniversity of Cincinnati · USUniversity of Geneva · CH
Funding
Cytokine regulation of skin barrier functionR01AI095282 · NIAID · INDIANA UNIVERSITY INDIANAPOLIS · PI KAPLAN, MARK H · 2012 to 2022
$4.3MNIAID NIH HHS R01 AI095282
Abstract
Obesity and type 2 diabetes are associated with metabolic defects and adipose tissue inflammation. Foxp3
Indexed as
Adipose Tissue, BrownAdipose Tissue, WhiteAnimalsCold TemperatureFemaleForkhead Transcription FactorsMice, Inbred BALB CProteomePTEN PhosphohydrolaseReceptors, Adrenergic, betaSignal TransductionSTAT6 Transcription FactorT-Lymphocytes, RegulatoryUncoupling Protein 1Forkhead Transcription FactorsFoxp3 protein, mouseProteomePTEN PhosphohydrolaseReceptors, Adrenergic, betaSTAT6 Transcription FactorUcp1 protein, mouseUncoupling Protein 1adipose tissue functionBorcs6C17orf59cold exposureFoxp3metabolic functionmetabolismPTENregulatory T cellsSTAT6T cellsTregs
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