ArticlePloS one2017
Automated recording of home cage activity and temperature of individual rats housed in social groups: The Rodent Big Brother project.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 86 citations in OpenAlex.
- Refining drug screening with automated home cage monitoring: a crossover study in socially housed rats.Frontiers in toxicology · 2026Article
- eeeHive: a new HF RFID-based automated behavioral monitoring system enabling high spatiotemporal resolution tracking of group-housed animals.Frontiers in behavioral neuroscience · 2026Article
- WERF Endometriosis Phenome and Biobanking Harmonisation Project for Experimental Models in Endometriosis Research (EPHect-EM-Pain): methods to assess pain behaviour in rodent models of endometriosis.Molecular human reproduction · 2025Review
- Rodent home cage monitoring for preclinical safety pharmacology assessment: results of a multi-company validation evaluating nonclinical and clinical data from three compounds.Frontiers in toxicology · 2025Article
- Article
- Added Value of Sensor-Based Behavioural Monitoring in an Infectious Disease Study with Sheep Infected withAnimals : an open access journal from MDPI · 2024Article
- Development of a 3D tracking system for multiple marmosets under free-moving conditions.Communications biology · 2024Article
- MouseVUER: video based open-source system for laboratory mouse home-cage monitoring.Scientific reports · 2024Article
- Article
- Socially Integrated Polysubstance (SIP) system: An open-source solution for continuous monitoring of polysubstance fluid intake in group housed mice.Addiction neuroscience · 2023Article
- Passive radio frequency identification and video tracking for the determination of location and movement of broilers.Poultry science · 2023Article
- Article
- PiE: an open-source pipeline for home cage behavioral analysis.Frontiers in neuroscience · 2023Article
- Bouts of rest and physical activity in C57BL/6J mice.PloS one · 2023Article
- Scalable and modular wireless-network infrastructure for large-scale behavioural neuroscience.Nature biomedical engineering · 2022Article
- O mouse, where art thou? The Mouse Position Surveillance System (MoPSS)-an RFID-based tracking system.Behavior research methods · 2022Article
- Measuring Locomotor Activity and Behavioral Aspects of Rodents Living in the Home-Cage.Frontiers in behavioral neuroscience · 2022Review
- Long-Term Effects of Low-Intensity Blast Non-Inertial Brain Injury on Anxiety-Like Behaviors in Mice: Home-Cage Monitoring Assessments.Neurotrauma reports · 2022Article
- Refining Procedures within Regulatory Toxicology Studies: Improving Animal Welfare and Data.Animals : an open access journal from MDPI · 2021Review
- Developing Recommendations for Cumulative Endpoints and Lifetime Use for Research Animals.Animals : an open access journal from MDPI · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 3 institutions in 1 country.
Funding
Abstract
Measuring the activity and temperature of rats is commonly required in biomedical research. Conventional approaches necessitate single housing, which affects their behavior and wellbeing. We have used a subcutaneous radiofrequency identification (RFID) transponder to measure ambulatory activity and temperature of individual rats when group-housed in conventional, rack-mounted home cages. The transponder location and temperature is detected by a matrix of antennae in a baseplate under the cage. An infrared high-definition camera acquires side-view video of the cage and also enables automated detection of vertical activity. Validation studies showed that baseplate-derived ambulatory activity correlated well with manual tracking and with side-view whole-cage video pixel movement. This technology enables individual behavioral and temperature data to be acquired continuously from group-housed rats in their familiar, home cage environment. We demonstrate its ability to reliably detect naturally occurring behavioral effects, extending beyond the capabilities of routine observational tests and conventional monitoring equipment. It has numerous potential applications including safety pharmacology, toxicology, circadian biology, disease models and drug discovery.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.