Evidence map›Paper›PMID 28877030›Full record

ArticleRadiation research2017

Radiation Mitigating Properties of Intranasally Administered KL

Melpo Christofidou-Solomidou, Ralph A Pietrofesa, Evguenia Arguiri, Constantinos Koumenis, Robert Segal

Open access · greenAbstract read
In one paragraph

Article in Radiation research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

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  11. Cytokines and radiation-induced pulmonary injuries.Journal of radiation research · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Melpo Christofidou-Solomidoua  Division of Pulmonary, Allergy, and Critical Care Medicine and the Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, 19104.
Ralph A Pietrofesaa  Division of Pulmonary, Allergy, and Critical Care Medicine and the Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, 19104.
Evguenia Arguiria  Division of Pulmonary, Allergy, and Critical Care Medicine and the Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, 19104.
Constantinos Koumenisb  Department of Radiation Oncology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, 19104.
Robert Segalc  Windtree Therapeutics, Inc., Warrington, Pennsylvania, 18976.
University of Pennsylvania · USWindtree Therapeutics (United States) · US

Funding

KL4 Surfactant to Mitigate Radiation-Induced Lung InjuryR44AI102308 · NIAID · WINDTREE THERAPEUTICS, INC. · PI SEGAL, ROBERT · 2014 to 2016
$3.0M
NIAID NIH HHS R44 AI102308
6 · The paper itself

Abstract

The threat of exposure to ionizing radiation from a nuclear reactor accident or deliberate terrorist actions is a significant public health concern. The lung is particularly susceptible to radiation-induced injury from external sources or inhalation of radioactive particles from radioactive fallout. Radiation-induced lung disease can manifest with an acute radiation pneumonitis and/or delayed effects leading to pulmonary fibrosis. As prior warning of radiation exposure is unlikely, medical countermeasures (MCMs) to mitigate radiation-induced lung disease that can be given in mass-casualty situations many hours or days postirradiation are needed to prevent both early and late lung damage. In this study, KL

Indexed as

Administration, IntranasalAnimalsDisease Models, AnimalDose-Response Relationship, DrugFemaleFibrosisIntercellular Signaling Peptides and ProteinsLungMiceOxidative StressPeptidesRadiation PneumonitisIntercellular Signaling Peptides and ProteinsKL4 surfactantPeptides

Identifiers

PMID28877030
PMCPMC5704933
OpenAlexW2751194536

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.