Evidence map›Paper›PMID 28876298›Full record

ArticleSexually transmitted diseases2018

Mailed Human Papillomavirus Self-Collection With Papanicolaou Test Referral for Infrequently Screened Women in the United States.

Jennifer S Smith, Andrea C Des Marais, Allison M Deal, Alice R Richman, Carolina Perez-Heydrich, Belinda Yen-Lieberman, Lynn Barclay, Jerome Belinson, Allen Rinas, Noel T Brewer

Open access · greenAbstract read
In one paragraph

Article in Sexually transmitted diseases, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Variation in Cervical Cancer Screening Preferences among Medically Underserved Individuals in the United States: A Systematic Review.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2020
    Pooled it
  4. Trial
  5. A Mail-Based HPV Self-Collection Program to Increase Cervical Cancer Screening in Appalachia: Results of a Group Randomized Trial.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Trial
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  8. Performance and acceptability of self-collected human papillomavirus testing among women living with HIV.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
    Trial
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  20. Comment on Self-Sampling Methodology Impression for Cervical Cancer Screening.Asian Pacific journal of cancer prevention : APJCP · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Jennifer S Smith
Andrea C Des Marais
Allison M Deal
Alice R Richman
Carolina Perez-Heydrich
Belinda Yen-Lieberman
Lynn Barclay
Jerome Belinson
Allen Rinas
Noel T Brewer
Cleveland Clinic · USUNC Lineberger Comprehensive Cancer CenterUniversity of North Carolina at Chapel Hill · USAmerican Sexual Health Association · USEast Carolina University · USMeredith College · US

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Virology, Immunology, and Microbiology CoreP30AI050410 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI DAVID M. MARGOLIS · 2001 to 2026
$76.9M
Targeting the MEKK2-ERK5 Signaling Node in Triple Negative Breast CancerU54CA156733 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI EARP, H. SHELTON · 2010 to 2020
$9.7M
Effect of HPV Self-Collection on Cervical Cancer Screening in High Risk WomenR01CA183891 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SMITH, JENNIFER SUSAN · 2015 to 2019
$3.0M
NCI NIH HHS P30 CA016086NCI NIH HHS R01 CA183891NCI NIH HHS U54 CA156733NIAID NIH HHS P30 AI050410
6 · The paper itself

Abstract

backgroundTesting for high-risk human papillomavirus (HPV) infection using mailed, self-collected samples is a promising approach to increase screening in women who do not attend clinic screening at recommended intervals.

methodsTo assess this intervention among high-risk women in the United States, 429 women without a Papanicolaou (Pap) test in 4 or more years (overdue by US guidelines) were recruited from the general population. Participants aged 30 to 65 years were mailed a kit to self-collect a cervicovaginal sample at home, return the sample by mail, and receive HPV results by telephone, with referral to follow-up cytological Pap testing at a local clinic. Cervicovaginal self-samples were collected with a Viba brush, stored in Scope mouthwash, and tested by Hybrid Capture 2. Data were collected in 2010 to 2011 and analyzed in 2017.

resultsTwo-thirds (64%) of participants returned a self-collected sample, of whom 15% tested HPV DNA positive. Human papillomavirus self-test-positive women reported higher rates of follow-up Pap tests (82%) than did those with self-test negative results (51%). No demographic differences were found in self-test return rate or HPV positivity. High acceptability was reported in participant surveys: most women (81%) had "mostly positive" overall thoughts about the self-test, and most reported being comfortable receiving the kit in the mail (99%), returning their self-collected sample by mail (82%), and receiving their test results by telephone (97%).

conclusionsConducting HPV self-testing through population-based recruitment, mailed kit delivery and return by mail, and results delivery by telephone has the potential to reach a broad segment of US underscreened women.

Indexed as

Human Papillomavirus DNA TestsPapanicolaou TestAdultEarly Detection of CancerFeasibility StudiesFemaleHumansMass ScreeningMiddle AgedPapillomaviridaePapillomavirus InfectionsPatient Acceptance of Health CarePatient ComplianceReferral and ConsultationSelf CareSpecimen Handling

Identifiers

PMID28876298
PMCPMC5846187
OpenAlexW2737444936

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.