Evidence map›Paper›PMID 28876289›Full record

ArticleSexually transmitted diseases2017

Neisseria gonorrhoeae Transmission Among Men Who Have Sex With Men: An Anatomical Site-Specific Mathematical Model Evaluating the Potential Preventive Impact of Mouthwash.

Lei Zhang, David G Regan, Eric P F Chow, Manoj Gambhir, Vincent Cornelisse, Andrew Grulich, Jason Ong, David A Lewis, Jane Hocking, Christopher K Fairley

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In one paragraph

Article in Sexually transmitted diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 76 citations in OpenAlex.

  1. Trial
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  8. The Natural History of Rectal Gonococcal and Chlamydial Infections: The ExGen Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Observational
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  19. The frontiers of addressing antibiotic resistance in Neisseria gonorrhoeae.Translational research : the journal of laboratory and clinical medicine · 2020
    Review
  20. CommensalPathogens (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Lei ZhangFrom the *Melbourne Sexual Health Centre; †Central Clinical School; ‡School of Public Health and Preventive Medicine, Faculty of Medicine, Monash University, Melbourne, Australia; §Research Centre for Public Health, Tsinghua University, Beijing, China; ¶Kirby Institute, UNSW Australia; ∥Marie Bashir Institute for Infectious Diseases & Biosecurity and Sydney Medical School-Westmead, University of Sydney, Sydney; **Western Sydney Sexual Health Centre, Western Sydney Local Health District, Parramatta; and ††Melbourne School of Population and Global Health, Melbourne University, Melbourne, Australia.
David G Regan
Eric P F Chow
Manoj Gambhir
Vincent Cornelisse
Andrew Grulich
Jason Ong
David A Lewis
Jane Hocking
Christopher K Fairley
Melbourne Health · AUSydney Sexual Health Centre · AUCentral Clinical Hospital · PLMonash University · AUSydney Local Health District · AUUniversity of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGonorrhoea notifications are rapidly rising in men who have sex with men (MSM). We developed a model to assess mouthwash as a novel intervention for gonorrhoea control.

methodsWe developed a model of Neisseria gonorrhoeae (NG) transmission to explain anatomic site-specific prevalence of gonorrhoea among MSM. The model was calibrated to available epidemiological and behavioral data. We estimated the contribution of various sexual acts to gonorrhoea incidence and evaluate the potential impacts of screening scale-up and utilization of mouthwash on the gonorrhoea epidemic.

resultsWe calibrated the model to prevalence of oropharyngeal, anal, and urethral gonorrhoea of 8.6% (7.7-9.5%), 8.3% (7.4-9.1%), and 0.20% (0.04-0.35%), respectively, among MSM. Oropharynx to oropharynx transmission through kissing is estimated to account for nearly three quarters of all incident cases (71.6% [64.4-80.5%]) of gonorrhoea in MSM. Substantially increasing annual oropharynx screening for gonorrhoea from the current 40% to 100% may only halve the prevalence of gonorrhoea in MSM. In contrast, the use of mouthwash with moderate efficacy (additional 1% clearance per daily use) would further reduce the corresponding prevalence rates to 3.1% (2.2-4.4%), 3.8% (2.3-4.9%), and 0.10% (0.06-0.11%), and a high-efficacy mouthwash (additional 1.5% clearance per daily use) may further halve the gonorrhoea prevalence. Without oropharynx to oropharynx transmission, we could not replicate current prevalence data.

conclusionsDespite a dearth of empirical data, our model suggests that kissing could potentially play an important role in NG transmission among MSM. Control through sexually transmitted infection screening alone is unlikely to have a substantial impact on the gonorrhoea epidemic in MSM.

Indexed as

Models, TheoreticalAnal CanalCoitusGonorrheaHomosexuality, MaleHumansMaleMouthwashesNeisseria gonorrhoeaeOropharynxPrevalenceSexual and Gender MinoritiesSexual BehaviorUrethraMouthwashes

Identifiers

PMID28876289
OpenAlexW2748783815

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.