Evidence map›Paper›PMID 28875937›Full record

ArticleeLife2017

Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of

Barbara Tavares, Raquel Jacinto, Pedro Sampaio, Sara Pestana, Andreia Pinto, Andreia Vaz, Mónica Roxo-Rosa, Rui Gardner, Telma Lopes, Britta Schilling and 3 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. PCD Genes-From Patients to Model Organisms and Back to Humans.International journal of molecular sciences · 2022
    Review
  8. Review
  9. Dand5 is involved in zebrafish tailbud cell movement.Frontiers in cell and developmental biology · 2022
    Article
  10. Review
  11. Article
  12. Zebrafish Motile Cilia as a Model for Primary Ciliary Dyskinesia.International journal of molecular sciences · 2021
    Article
  13. Article
  14. Pkd2 Affects Cilia Length and Impacts LR Flow Dynamics andFrontiers in cell and developmental biology · 2021
    Article
  15. Article
  16. Article
  17. Signaling through the Primary Cilium.Frontiers in cell and developmental biology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Barbara Tavares *CEDOC, Chronic Diseases Research Centre, NOVA Medical School - Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal.
Raquel Jacinto *CEDOC, Chronic Diseases Research Centre, NOVA Medical School - Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal.ORCID http://orcid.org/0000-0002-4029-0204
Pedro SampaioCEDOC, Chronic Diseases Research Centre, NOVA Medical School - Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal.
Sara PestanaCEDOC, Chronic Diseases Research Centre, NOVA Medical School - Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal.
Andreia PintoLaboratório de Histologia e Patologia Comparada, Instituto de Medicina Molecular, Centro Académico de Medicina de Lisboa, Lisboa, Portugal.
Andreia VazCEDOC, Chronic Diseases Research Centre, NOVA Medical School - Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal.
Mónica Roxo-RosaCEDOC, Chronic Diseases Research Centre, NOVA Medical School - Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal.
Rui GardnerInstituto Gulbenkian de Ciência, Oeiras, Portugal.
Telma LopesInstituto Gulbenkian de Ciência, Oeiras, Portugal.
Britta SchillingMPI of Molecular Cell Biology and Genetics, Dresden, Germany.
Ian HenryMPI of Molecular Cell Biology and Genetics, Dresden, Germany.
Leonor SaúdeInstituto de Medicina Molecular e Instituto de Histologia e Biologia do Desenvolvimento, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal.
Susana Santos LopesCEDOC, Chronic Diseases Research Centre, NOVA Medical School - Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisboa, Portugal.ORCID http://orcid.org/0000-0002-6733-6356
Universidade Nova de Lisboa · PTInstituto Gulbenkian de Ciência · PTMax Planck Institute of Molecular Cell Biology and Genetics · DEInstituto de Medicina Molecular João Lobo AntunesUniversity of Lisbon · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Foxj1a is necessary and sufficient to specify motile cilia. Using transcriptional studies and slow-scan two-photon live imaging capable of identifying the number of motile and immotile cilia, we now established that the final number of motile cilia depends on Notch signalling (NS). We found that despite all left-right organizer (LRO) cells express

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsCiliaForkhead Transcription FactorsGene Expression ProfilingIntravital MicroscopyMicroscopy, FluorescenceMotionReceptors, NotchSignal TransductionZebrafishZebrafish ProteinsBasic Helix-Loop-Helix ProteinsForkhead Transcription FactorsFoxj1a protein, zebrafishher12 protein, zebrafishReceptors, NotchZebrafish Proteinscilia motilityciliary epitheliumdevelopmental biologyfluid flow dynamicsher12left-rightNotch signallingstem cellszebrafish

Identifiers

PMID28875937
PMCPMC5608511
OpenAlexW2752837578

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.