ArticleThe Journal of cell biology1987
Three-dimensional reconstruction of a peroxisomal reticulum in regenerating rat liver: evidence of interconnections between heterogeneous segments.
Article in The Journal of cell biology, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 122 citations in OpenAlex.
- Visualisation of peroxisomes: a journey through seven decades.Histochemistry and cell biology · 2026Review
- ACOX-driven peroxisomal heterogeneity and functional compartmentalization in brown adipocytes of hypothyroid rats.Royal Society open science · 2023Article
- Organelle Membrane Extensions in Mammalian Cells.Biology · 2023Review
- Hypothyroidism Intensifies Both Canonic and theCells · 2021Article
- A Functional SMAD2/3 Binding Site in theFrontiers in cell and developmental biology · 2020Article
- Current and Emerging Approaches for Studying Inter-Organelle Membrane Contact Sites.Frontiers in cell and developmental biology · 2020Review
- Redox Regulation of Homeostasis and Proteostasis in Peroxisomes.Physiological reviews · 2018Review
- Peroxisomal ACBD4 interacts with VAPB and promotes ER-peroxisome associations.Cell cycle (Georgetown, Tex.) · 2017Article
- Super-resolution Microscopy Reveals Compartmentalization of Peroxisomal Membrane Proteins.The Journal of biological chemistry · 2016Article
- No peroxisome is an island - Peroxisome contact sites.Biochimica et biophysica acta · 2016Review
- C22-bronchial and T7-alveolar epithelial cell lines of the immortomouse are excellent murine cell culture model systems to study pulmonary peroxisome biology and metabolism.Histochemistry and cell biology · 2016Article
- Peroxisomes take shape.Nature reviews. Molecular cell biology · 2013Review
- The biogenesis protein PEX14 is an optimal marker for the identification and localization of peroxisomes in different cell types, tissues, and species in morphological studies.Histochemistry and cell biology · 2013Article
- Simultaneous live-imaging of peroxisomes and the ER in plant cells suggests contiguity but no luminal continuity between the two organelles.Frontiers in physiology · 2013Article
- Organelle dynamics and dysfunction: A closer link between peroxisomes and mitochondria.Journal of inherited metabolic disease · 2009Review
- Mammalian peroxisomes and reactive oxygen species.Histochemistry and cell biology · 2004Review
- Involvement of the endoplasmic reticulum in peroxisome formation.Molecular biology of the cell · 2003Article
- FRET microscopy demonstrates molecular association of non-specific lipid transfer protein (nsL-TP) with fatty acid oxidation enzymes in peroxisomes.The EMBO journal · 1998Article
- Redox-sensitive homodimerization of Pex11p: a proposed mechanism to regulate peroxisomal division.The Journal of cell biology · 1996Article
- Effects of fixation on the preservation of peroxisomal structures for immunofluorescence studies using HepG2 cells as a model system.The Histochemical journal · 1995Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The three-dimensional (3-D) form and the interrelationship of peroxisomes (Po) in the model of regenerating rat liver after partial hepatectomy were studied by computer-assisted 3-D reconstruction of serial ultrathin sections. Po were labeled cytochemically for either catalase, which stains them all uniformly, or for D-amino acid oxidase (DAA-OX), which gives a heterogeneous reaction with lightly and darkly stained PO. In regenerating rat liver, Po exhibit marked pleomorphism with some budding forms and dumbbell-shaped ones. The 3-D reconstruction revealed many single spherical Po measuring 0.15-0.8 micron in diameter. In addition, two to five Po were found interconnected with each other via narrow 30-50-nm hourglass-shaped bridges forming a reticulum. Such aggregates of Po measured 1.5-2.5 microns across. Whereas all segments of this reticulum stained homogeneously for catalase, they exhibited a marked difference in the intensity of the DAA-OX reaction. These observations are consistent with the view of peroxisomal proliferation by budding or fragmentation from preexisting ones. Under such conditions of rapid growth as in regenerating liver, Po may be interconnected forming a reticulum. The interconnections between Po with differing DAA-OX activities suggest that they originate from the same parent organelle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.