ArticleClinical pharmacology and therapeutics2018
Group-Based Trajectory Models: Assessing Adherence to Antihypertensive Medication in Older Adults in a Community Pharmacy Setting.
Article in Clinical pharmacology and therapeutics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Medication Adherence Trajectories: A Systematic Literature Review.Journal of managed care & specialty pharmacy · 2020Pooled it
- A data-driven typology of asthma medication adherence using cluster analysis.Scientific reports · 2020Trial
- Real-World Adherence Patterns and Predictors of GLP-1 Receptor Agonist Use for Obesity Management in a Medicaid Population.Advances in therapy · 2026Article
- Transparent reporting of group-based trajectory modeling to study medication adherence: Practical considerations and common pitfalls.Journal of managed care & specialty pharmacy · 2026Article
- Article
- Nonadherence to Antiviral Therapy Leading to Severe Hepatic Decompensation in a Patient With Chronic Hepatitis B.ACG case reports journal · 2026Article
- Adherence to oral thromboprophylaxis in atrial fibrillation: an overview for clinicians.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025Review
- Investigating the Time-Varying Nature of Medication Adherence Predictors: An Experimental Approach Using Andersen's Behavioral Model of Health Services Use.Pharmacy (Basel, Switzerland) · 2025Article
- Medication adherence trajectory and its impact on recurrent stroke after carotid artery stenting.Frontiers in neurology · 2025Article
- Enhancing DHA supplementation adherence: A Bayesian approach with finite mixture models and irregular interim schedules in adaptive trial designs.Statistical methods in medical research · 2024Article
- Trajectory and predictors of adherence to Nucleos(t)ide analogues medication among patients with chronic hepatitis B.Heliyon · 2024Article
- Using large administrative data for mining patients' trajectories for risk stratification: An example from urological diseases.PloS one · 2024Article
- Association of High-Deductible Health Plan Enrollment With Spending on and Use of Lenalidomide Therapy Among Commercially Insured Patients With Multiple Myeloma.JAMA network open · 2022Article
- Identifying temporal patterns of adherence to antidepressants, bisphosphonates and statins, and associated patient factors.SSM - population health · 2022Article
- Assessing Concurrent Adherence to Combined Essential Medication and Clinical Outcomes in Patients With Acute Coronary Syndrome. A Population-Based, Real-World Study Using Group-Based Trajectory Models.Frontiers in cardiovascular medicine · 2022Article
- Trajectories of Prescription Opioid Utilization During Pregnancy Among Prepregnancy Chronic Users and Risk of Neonatal Opioid Withdrawal Syndrome.American journal of epidemiology · 2022Article
- Comparing Continuous and Binary Group-based Trajectory Modeling Using Statin Medication Adherence Data.Medical care · 2021Article
- Identifying adherent patients to newly initiated statins using previous adherence to chronic medications.Journal of managed care & specialty pharmacy · 2021Article
- Exploring Culture, Religiosity and Spirituality Influence on Antihypertensive Medication Adherence Among Specialised Population: A Qualitative Ethnographic Approach.Patient preference and adherence · 2021Article
- Opening the black box of the group-based trajectory modeling process to analyze medication adherence patterns: An example using real-world statin adherence data.Pharmacoepidemiology and drug safety · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antihypertensive medication nonadherence is highly prevalent, leading to uncontrolled blood pressure. Methods that facilitate the targeting and tailoring of adherence interventions in clinical settings are required. Group-Based Trajectory Modeling (GBTM) is a newer method to evaluate adherence using pharmacy dispensing (refill) data that has advantages over traditional refill adherence metrics (e.g. Proportion of Days Covered) by identifying groups of patients who may benefit from adherence interventions, and identifying patterns of adherence behavior over time that may facilitate tailoring of an adherence intervention. We evaluated adherence to antihypertensive medication in 905 patients over a 12-month period in a community pharmacy setting using GBTM, identifying three subgroups of adherence patterns: 52.8%, 40.7%, and 6.5% had very high, high, and low adherence, respectively. However, GBTM failed to demonstrate predictive validity with blood pressure at 12 months. Further research on the validity of adherence measures that facilitate interventions in clinical settings is required.
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