Evidence map›Paper›PMID 28875553›Full record

ArticleThe Journal of comparative neurology2018

Human brain imaging of nicotinic acetylcholine α4β2* receptors using [

Jogeshwar Mukherjee, Patrick J Lao, Tobey J Betthauser, Gurleen K Samra, Min-Liang Pan, Ishani H Patel, Christopher Liang, Raju Metherate, Bradley T Christian

Open access · greenAbstract read
In one paragraph

Article in The Journal of comparative neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 38 citations in OpenAlex.

  1. Trial
  2. Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018
    Trial
  3. Increased Binding of [Synapse (New York, N.Y.) · 2026
    Article
  4. Imaging [bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Review
  7. Reduction in [Brain research · 2025
    Article
  8. Article
  9. Evaluation of [Receptors (Basel, Switzerland) · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Abnormal [Synapse (New York, N.Y.) · 2023
    Article
  17. Trapping of Nicotinic Acetylcholine Receptor Ligands Assayed byThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  18. Article
  19. [Molecules (Basel, Switzerland) · 2021
    Article
  20. NRM 2021 Abstract Booklet.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jogeshwar MukherjeePreclinical Imaging, Department of Radiological Sciences, University of California, Irvine, California.ORCID http://orcid.org/0000-0003-1009-877X
Patrick J LaoDepartment of Medical Physics and Waisman Center, University of Wisconsin, Madison, Wisconsin.
Tobey J BetthauserDepartment of Medical Physics and Waisman Center, University of Wisconsin, Madison, Wisconsin.
Gurleen K SamraPreclinical Imaging, Department of Radiological Sciences, University of California, Irvine, California.
Min-Liang PanPreclinical Imaging, Department of Radiological Sciences, University of California, Irvine, California.
Ishani H PatelPreclinical Imaging, Department of Radiological Sciences, University of California, Irvine, California.
Christopher Liang
Raju MetherateDepartment of Neurobiology and Behavior, University of California, Irvine, California.
Bradley T ChristianDepartment of Medical Physics and Waisman Center, University of Wisconsin, Madison, Wisconsin.
University of California, Irvine · USUniversity of Wisconsin–Madison · US

Funding

U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
PET Imaging Agents for Nicotinic a4b2 ReceptorsR01AG029479 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI MUKHERJEE, JOGESHWAR · 2007 to 2017
$2.6M
PET Imaging agents for a4b2 Nicotinic ReceptorsRF1AG029479 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHRISTIAN, BRADLEY T, MUKHERJEE, JOGESHWAR · 2019 to 2020
$2.2M
Functions of Nicotine Receptors in Sensory NeocortexR01DC013200 · NIDCD · UNIVERSITY OF CALIFORNIA-IRVINE · PI METHERATE, RAJU · 2013 to 2017
$1.7M
NCI NIH HHS T32 CA009206NIA NIH HHS R01 AG029479NIA NIH HHS RF1 AG029479NIDCD NIH HHS R01 DC013200
6 · The paper itself

Abstract

Nicotinic acetylcholinergic receptors (nAChR's) have been implicated in several brain disorders, including addiction, Parkinson's disease, Alzheimer's disease and schizophrenia. Here we report in vitro selectivity and functional properties, toxicity in rats, in vivo evaluation in humans, and comparison across species of [

Indexed as

BrainSex CharacteristicsAdultAgedAgingAnimalsDose-Response Relationship, DrugFemaleHumansMacaca mulattaMaleMiceMiddle AgedNicotineNicotinic AgonistsPositron-Emission TomographyNicotineNicotinic Agonistsnicotinic receptor alpha4beta2nifenePyridinesPyrrolesReceptors, Nicotiniccortical pathwayreceptor selectivityRRID:SCR_005279RRID:SCR_007416RRID:SCR_014214thalamustranslational researchwhite matter tracts

Identifiers

PMID28875553
PMCPMC5788574
OpenAlexW2753309100

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.