Evidence map›Paper›PMID 28875496›Full record

ArticleInternational journal of cancer2018

G protein-coupled receptor GPR55 promotes colorectal cancer and has opposing effects to cannabinoid receptor 1.

Carina Hasenoehrl, David Feuersinger, Eva M Sturm, Thomas Bärnthaler, Ellen Heitzer, Ricarda Graf, Magdalena Grill, Martin Pichler, Stephan Beck, Lee Butcher and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in International journal of cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Cannabidiol-Ion Channel Interactions Represent a Promising Preventive and Therapeutic Strategy in Hepatocellular Carcinoma.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  4. Article
  5. Review
  6. Article
  7. Article
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  9. Article
  10. Article
  11. Article
  12. Review
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  14. Motor-like Tics are Mediated by CBMolecular neurobiology · 2022
    Article
  15. Prognostic Significance ofInternational journal of molecular sciences · 2022
    Article
  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 3 countries.

Carina HasenoehrlInstitute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.
David FeuersingerInstitute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.
Eva M SturmInstitute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.
Thomas BärnthalerInstitute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.
Ellen HeitzerInstitute of Human Genetics, Medical University of Graz, Graz, Austria.
Ricarda GrafInstitute of Human Genetics, Medical University of Graz, Graz, Austria.
Magdalena GrillInstitute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.
Martin PichlerDepartment of Internal Medicine, Division of Oncology, Medical University of Graz, Graz, Austria.
Stephan BeckUCL Cancer Institute, University College London, London, United Kingdom.
Lee ButcherUCL Cancer Institute, University College London, London, United Kingdom.
Dominique ThomasInstitute of Clinical Pharmacology, Goethe University, Frankfurt/Main, Germany.
Nerea FerreirósInstitute of Clinical Pharmacology, Goethe University, Frankfurt/Main, Germany.
Rufina SchuligoiInstitute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.
Caroline SchweigerInstitute of Pathology, Medical University of Graz, Graz, Austria.
Johannes HaybaeckInstitute of Pathology, Medical University of Graz, Graz, Austria.
Rudolf SchichoInstitute of Experimental and Clinical Pharmacology, Medical University of Graz, Graz, Austria.ORCID 0000-0002-5726-4731
Medical University of Graz · ATCRUK Lung Cancer Centre of Excellence · GBGoethe University Frankfurt · DE

Funding

Austrian Science Fund FWF KLI 521Austrian Science Fund FWF P 25633
6 · The paper itself

Abstract

The putative cannabinoid receptor GPR55 has been shown to play a tumor-promoting role in various cancers, and is involved in many physiological and pathological processes of the gastrointestinal (GI) tract. While the cannabinoid receptor 1 (CB

Indexed as

AnimalsCarcinogenesisColorectal NeoplasmsHumansMiceMice, KnockoutReceptor, Cannabinoid, CB1Receptors, CannabinoidReceptors, G-Protein-CoupledGPR55 protein, humanGPR55 protein, mouseReceptor, Cannabinoid, CB1Receptors, CannabinoidReceptors, G-Protein-CoupledCB1CNR1colorectal carcinogenesisGPR55

Identifiers

PMID28875496
PMCPMC5679368
OpenAlexW2753262550

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.