ArticleInternational journal of clinical oncology2018
Potential predictive factors for microvascular invasion in hepatocellular carcinoma classified within the Milan criteria.
Article in International journal of clinical oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Preoperative Prediction of Microvascular Invasion in Hepatocellular Carcinoma: A Chinese Retrospective Multicenter Study Based on Global Meta-Analysis.Cancer medicine · 2026Pooled it
- Conversion Resection or Direct Resection for Patients with Intermediate-Stage Hepatocellular Carcinoma: A Multicentre Study.Liver cancer · 2026Article
- Preoperative circulating tumor cells indicate microvascular invasion and dynamical detection indicate the early recurrence of hepatocellular carcinoma.BMC cancer · 2025Article
- Chinese expert consensus on the diagnosis and treatment of hepatocellular carcinoma with microvascular invasion (2024 edition).Hepatobiliary surgery and nutrition · 2025Review
- New predictors of microvascular invasion for small hepatocellular carcinoma ≤ 3 cm.International journal of clinical oncology · 2024Article
- Preoperative prediction of microvascular invasion classification in hepatocellular carcinoma based on clinical features and MRI parameters.Oncology letters · 2024Article
- Prediction of preoperative microvascular invasion by dynamic radiomic analysis based on contrast-enhanced computed tomography.Abdominal radiology (New York) · 2024Article
- Treatments for recurrent hepatocellular carcinoma: laparoscopic or open repeat liver resection, how to make a decision?Updates in surgery · 2023Article
- Preoperative determination of pathological grades of primary single HCC: development and validation of a scoring model.Abdominal radiology (New York) · 2022Article
- Prediction of microvascular invasion in HCC by a scoring model combining Gd-EOB-DTPA MRI and biochemical indicators.European radiology · 2022Article
- A Clinical-Radiomic Model for Predicting Indocyanine Green Retention Rate at 15 Min in Patients With Hepatocellular Carcinoma.Frontiers in surgery · 2022Article
- Using Systemic Inflammatory Markers to Predict Microvascular Invasion Before Surgery in Patients With Hepatocellular Carcinoma.Frontiers in surgery · 2022Article
- Risk Score Model for Microvascular Invasion in Hepatocellular Carcinoma: The Role of Tumor Burden and Alpha-Fetoprotein.Cancers · 2021Article
- Article
- The antitumour effect of galangin and luteolin with doxorubicin on chemically induced hepatocellular carcinoma in rats.Contemporary oncology (Poznan, Poland) · 2021Article
- The effect of bile duct tumor thrombus on the long-term prognosis of hepatocellular carcinoma patients after liver resection: a systematic review and meta-analysis.Annals of translational medicine · 2020Article
- Correlation of postoperative splenic volume increase with prognosis of hepatocellular carcinoma after curative hepatectomyCanadian journal of surgery. Journal canadien de chirurgie · 2019Article
- Model-based three-dimensional texture analysis of contrast-enhanced magnetic resonance imaging as a potential tool for preoperative prediction of microvascular invasion in hepatocellular carcinoma.Oncology letters · 2019Article
- Effect of prophylactic transcatheter arterial chemoembolization on hepatocellular carcinoma with microvascular invasion after R0 resection. A case-control study.Sao Paulo medical journal = Revista paulista de medicinaArticle
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10 authors.
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Abstract
backgroundMicrovascular invasion (mvi) is an important risk factor for recurrent hepatocellular carcinoma (HCC), even after curative liver resection or orthotopic liver transplantation. However, mvi is difficult to detect preoperatively. The aim of this study was to clarify the risk factors of postoperative recurrence and investigate predictive factors of mvi before hepatectomy for HCC classified within the Milan criteria.
methodsOne hundred fifty-nine patients with hepatocellular carcinoma (HCC) classified within the Milan criteria, who underwent hepatectomy, were enrolled in this study. We investigated the risk factors of recurrence. In addition, we divided them into two groups: mvi-negative group and mvi-positive group, based on pathological findings after surgery. We compared the clinicopathological factors between the two groups and determined the risk factors for mvi.
resultsOverall survival rate at 1, 3, and 5 years were 91.6%, 80.5%, and 74.9%, and the recurrence-free survival rate at 1, 3, and 5-years were 72.3%, 51.6%, and 37.2%. Risk factor analysis for tumor recurrence revealed that total bilirubin, albumin, ICGR15, AFP-L3, tumor number, mvi, and tumor stage had a significant predictive value. Multivariate analysis revealed that tumor number and mvi were significant independent risk factors for tumor recurrence. Predictive analysis for risk factors of mvi revealed that multiple tumors and AFP-L3 > 10% were significant independent risk factors for mvi in HCC classified within the Milan criteria.
conclusionsThe mvi was one of the independent risk factors for tumor recurrence in HCC classified within the Milan criteria. Multiple tumors and high AFP-L3 value were independent predictive factors for mvi.
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