Evidence map›Paper›PMID 28875231›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2017

Cativic acid-caffeic acid hybrid exerts cytotoxic effects and induces apoptotic death in human neuroblastoma cells.

Natalia P Alza, Ana P Murray, Gabriela A Salvador

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Natalia P AlzaInstituto de Investigaciones Bioquímicas de Bahía Blanca, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur y Consejo Nacional de Investigaciones Científicas y Técnicas, Camino La Carrindanga km 7, 8000, Bahía Blanca, Argentina.
Ana P MurrayInstituto de Química del Sur, Departamento de Química, Universidad Nacional del Sur y Consejo Nacional de Investigaciones Científicas y Técnicas, Av. Alem 1253, 8000, Bahía Blanca, Argentina.
Gabriela A SalvadorInstituto de Investigaciones Bioquímicas de Bahía Blanca, Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur y Consejo Nacional de Investigaciones Científicas y Técnicas, Camino La Carrindanga km 7, 8000, Bahía Blanca, Argentina. salvador@criba.edu.ar.

Funding

Consejo Nacional de Investigaciones Científicas y Técnicas PIP1122009010068Consejo Nacional de Investigaciones Científicas y Técnicas PIP11220100100392Fondo para la Investigación Científica y Tecnológica PICT-2011-0765Fondo para la Investigación Científica y Tecnológica PICT-2013-0987Universidad Nacional del Sur PGI24B179Universidad Nacional del Sur PGI24Q071
6 · The paper itself

Abstract

The development of hybrids from natural products is a promising strategy for drug discovery. In cancer therapy, there is a need to discover novel agents that can induce apoptosis in cancer cells. To contribute to this field of interest, we investigated the effect of a synthetic hybrid from cativic acid and caffeic acid (5) on viability, proliferation, and apoptosis in human neuroblastoma cells (IMR-32). Three hybrids were prepared via Mitsunobu esterification from 17-hydroxycativic acid (1) and natural phenols. Cell viability was analyzed by MTT assay. SYTOX green and LDH leakage were used to determine the cytotoxic effect. Caspase-3 activity, cell cycle phases, and proliferation were analyzed in order to characterize the biological effects of hybrid 5. The mitogen-activated protein kinase (MAPK) status was evaluated for elucidating the potential mechanisms involved in hybrid 5 effect. Hybrid 5 reduced the viability of IMR-32 cells in a time- and concentration-dependent manner (IC

Indexed as

Antineoplastic Agents, PhytogenicApoptosisCaffeic AcidsCaspase 3Cell CycleCell Line, TumorDiterpenesGrindeliaHumansJNK Mitogen-Activated Protein KinasesMAP Kinase Signaling SystemMitogen-Activated Protein KinasesNeuroblastomaNuclear Localization Signals17-hydroxycativic acidAntineoplastic Agents, Phytogeniccaffeic acidCaffeic AcidsCASP3 protein, humanCaspase 3DiterpenesJNK Mitogen-Activated Protein KinasesMitogen-Activated Protein KinasesNuclear Localization SignalsApoptosisCativic acidHuman neuroblastomaHybridsMAPK

Identifiers

PMID28875231

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.