ArticleOpen forum infectious diseases2017
Risk of Tuberculosis Infection and Disease for Health Care Workers: An Updated Meta-Analysis.
Article in Open forum infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
87 citing papers in PubMed, 5 syntheses or guidelines pooled it, 157 citations in OpenAlex.
- Mycobacterium tuberculosis latent infection in healthcare students: systematic review of prevalence.Revista da Escola de Enfermagem da U S P · 2024Pooled it
- Pooled it
- Evidence for the Use of Triage, Respiratory Isolation, and Effective Treatment to Reduce the Transmission of Mycobacterium Tuberculosis in Healthcare Settings: A Systematic Review.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Pooled it
- Risk of Occupational Latent Tuberculosis Infection among Health Personnel Measured by Interferon-Gamma Release Assays in Low Incidence Countries-A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020Pooled it
- Implementation strategies for infection prevention and control promotion for nurses in Sub-Saharan Africa: a systematic review.Implementation science : IS · 2019Pooled it
- Trial
- Prevalence and risk factors for latent tuberculosis infection among healthcare workers in Morocco.PloS one · 2019Trial
- The prevalence of latent tuberculosis infection among healthcare workers in Saudi Arabia: a systematic review and meta-analysis.IJID regions · 2026Article
- Structural guidelines for the sustainability of the tuberculosis infection control planBiomedica : revista del Instituto Nacional de Salud · 2026Article
- Diagnostic performance of stimulated plasma interferon-gamma inducible protein 10 (IP-10) for diagnosing latent tuberculosis infection in healthcare workers.Scientific reports · 2026Article
- Performance of TB Antigen-Based Skin Tests Amongst Healthcare Workers-Sevagram, India, 2023-2024.Open forum infectious diseases · 2026Article
- Comparative tuberculosis risk in healthcare and educational workers: occupational synergy.ERJ open research · 2026Article
- Series 1: Behind the Spread: A Scoping Review of Risk Factors for Exposure toTropical medicine and infectious disease · 2026Review
- Comparison of Tuberculosis Exposure Frequency and Latent Tuberculosis Infection Rates Among Healthcare Workers by Occupational Classification.Journal of clinical medicine · 2026Article
- Tuberculosis: An Ongoing Global Threat.Advances in experimental medicine and biology · 2026Review
- Factors associated with pulmonary tuberculosis in LTBI individuals screened from close contacts: a retrospective case-control study.Frontiers in public health · 2026Article
- Strategies for Tuberculosis Prevention in Healthcare Settings: A Narrative Review.Tropical medicine and infectious disease · 2025Review
- Prevalence and risk factors of latent tuberculosis infection in healthcare workers in Eastern China.BMC public health · 2025Article
- Perceptions of Occupational Risk and Adherence to Tuberculosis Prevention Among Health Care Workers: Protocol for a Scoping Review.JMIR research protocols · 2025Article
- Incidence and risk factors for tuberculosis at a rural HIV clinic in Uganda, 2012-2019; A retrospective cohort study.BMC public health · 2025Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTuberculosis (TB) remains a major challenge to global health. Healthcare workers (HCWs) appear to be at increased risk of TB compared with the general population, despite efforts to scale up infection control and reduce nosocomial TB transmission. This review aims to provide an updated estimate of the occupational risk of latent TB infection (LTBI) and active TB among HCWs compared with the general population.
methodsA systematic review was performed to identify studies published over the last 10 years reporting TB prevalence or incidence among HCWs and a control group. Pooled effect estimates were calculated to determine the risk of infection.
resultsTwenty-one studies met the inclusion criteria, providing data on 30961 HCWs across 16 countries. Prevalence of LTBI among HCWs was 37%, and mean incidence rate of active TB was 97/100000 per year. Compared with the general population, the risk of LTBI was greater for HCWs (odds ratio [OR], 2.27; 95% confidence interval [CI], 1.61-3.20), and the incidence rate ratio for active TB was 2.94 (95% CI, 1.67-5.19). Comparing tuberculin skin test and interferon-gamma release assay, OR for LTBI was found to be 1.72 and 5.61, respectively.
conclusionsThe overall risk of both LTBI and TB to HCWs continues to be significantly higher than that of the general population, consistent with previous findings. This study highlights the continuing need for improvements in infection control and HCW screening programs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.