Evidence map›Paper›PMID 28875154›Full record

ArticleOrthopaedic journal of sports medicine2017

Structural and Anatomic Restoration of the Anterior Cruciate Ligament Is Associated With Less Cartilage Damage 1 Year After Surgery: Healing Ligament Properties Affect Cartilage Damage.

Ata M Kiapour, Braden C Fleming, Martha M Murray

Open access · goldAbstract read
In one paragraph

Article in Orthopaedic journal of sports medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 24 citations in OpenAlex.

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  12. 6DOF knee kinematic alterations due to increased load levels.Frontiers in bioengineering and biotechnology · 2022
    Article
  13. A transfer learning approach for automatic segmentation of the surgically treated anterior cruciate ligament.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2022
    Article
  14. Article
  15. Automated magnetic resonance image segmentation of the anterior cruciate ligament.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021
    Article
  16. Cartilage Damage Is Related to ACL Stiffness in a Porcine Model of ACL Repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Ata M KiapourDepartment of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Braden C FlemingDepartment of Orthopaedics, Warren Alpert Medical School of Brown University and Rhode Island Hospital, Providence, Rhode Island, USA.
Martha M MurrayDepartment of Orthopaedic Surgery, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Boston Children's Hospital · USBrown University · USHarvard University · US

Funding

COBRE for Skeletal Health and RepairP20GM104937 · NIGMS · RHODE ISLAND HOSPITAL · PI CHEN, QIAN · 2012 to 2016
$10.8M
Pilot Projects ProgramP30GM122732 · NIGMS · RHODE ISLAND HOSPITAL · PI CHEN, QIAN · 2017 to 2021
$6.6M
Biologically Enhanced Healing of Autograft ACL Reconstruction.R01AR056834 · NIAMS · RHODE ISLAND HOSPITAL · PI FLEMING, BRADEN C, MURRAY, MARTHA M · 2009 to 2017
$5.8M
The Effect of Age on Functional ACL HealingR01AR054099 · NIAMS · BOSTON CHILDREN'S HOSPITAL · PI MURRAY, MARTHA M · 2006 to 2013
$4.8M
NIAMS NIH HHS R01 AR054099NIAMS NIH HHS R01 AR056834NIGMS NIH HHS P20 GM104937NIGMS NIH HHS P30 GM122732
6 · The paper itself

Abstract

backgroundAbnormal joint motion has been linked to joint arthrosis after anterior cruciate ligament (ACL) reconstruction. However, the relationships between the graft properties (ie, structural and anatomic) and extent of posttraumatic osteoarthritis are not well defined. HYPOTHESES: (1) The structural (tensile) and anatomic (area and alignment) properties of the reconstructed graft or repaired ACL correlate with the total cartilage lesion area 1 year after ACL surgery, and (2) side-to-side differences in anterior-posterior (AP) knee laxity correlate with the total cartilage lesion area 1 year postoperatively. STUDY

designControlled laboratory study.

methodsSixteen minipigs underwent unilateral ACL transection and were randomly treated with ACL reconstruction or bridge-enhanced ACL repair. The tensile properties, cross-sectional area, and multiplanar alignment of the healing ACL or graft, AP knee laxity, and cartilage lesion areas were assessed 1 year after surgery.

resultsIn the reconstructed group, the normalized graft yield and maximum failure loads, cross-sectional area, sagittal and coronal elevation angles, and side-to-side differences in AP knee laxity at 60° of flexion were associated with the total cartilage lesion area 1 year after surgery (

conclusionThe tensile properties, cross-sectional area, and multiplanar alignment of the healing ACLs or grafts and AP knee laxity in reconstructed knees were associated with the extent of tibiofemoral cartilage damage after ACL surgery. CLINICAL RELEVANCE: These data highlight the need for novel ACL injury treatments that can restore the structural and anatomic properties of the torn ACL to those of the native ACL in an effort to minimize the risk of early-onset posttraumatic osteoarthritis.

Indexed as

ACLcartilagehealingosteoarthritisreconstruction

Identifiers

PMID28875154
PMCPMC5576541
OpenAlexW2747114157

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.