ArticlePeerJ2017
Genes of the major histocompatibility complex highlight interactions of the innate and adaptive immune system.
Article in PeerJ, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Genetic parameters for welfare, infestation level, and inflammatory response traits in cage-free laying hens experimentally infested with northern fowl mites (Ornithonyssus sylviarum).Poultry science · 2026Article
- Adaptation in the Alleyways: Candidate Genes Under Potential Selection in Urban Coyotes.Genome biology and evolution · 2025Article
- Association of Major Histocompatibility Complex Polymorphism With Acute Phase Response in Broiler Chicken.Veterinary medicine and science · 2024Article
- How mites influence cage-free egg production in the United States, mite management strategies, and the mitigating role of genomic selection.Animal frontiers : the review magazine of animal agriculture · 2024Article
- Evolutionary trade-off between innate and acquired immune defences in birds.Frontiers in zoology · 2023Article
- Critical review of the phytohemagglutinin assay for assessing amphibian immunity.Conservation physiology · 2023Article
- Type 1 diabetes and engineering enhanced islet transplantation.Advanced drug delivery reviews · 2022Review
- Lipid-based nanoparticles for psoriasis treatment: a review on conventional treatments, recent works, and future prospects.RSC advances · 2021Review
- Adult survival in migratory caribou is negatively associated with MHC functional diversity.Heredity · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA well-functioning immune defence is crucial for fitness, but our knowledge about the immune system and its complex interactions is still limited. Major histocompatibility complex (MHC) molecules are involved in T-cell mediated adaptive immune responses, but MHC is also highly upregulated during the initial innate immune response. The aim of our study was therefore to determine to what extent the highly polymorphic MHC is involved in interactions of the innate and adaptive immune defence and if specific functional MHC alleles (FA) or heterozygosity at the MHC are more important.
methodsTo do this we used captive house sparrows (
resultsOur results reveal that MHC was linked to all immune tests, highlighting its importance for the immune defence. While all innate responses were associated with one single FA, adaptive responses (cell-mediated and humoral) were associated with several different alleles. DISCUSSION: We found that repeated injections of an antibody in nestlings and adults were linked to different FA and hence might affect different areas of the immune system. Also, individuals with a higher number of different FA produced a smaller secondary response, indicating a disadvantage of having numerous MHC alleles. These results demonstrate the complexity of the immune system in relation to the MHC and lay the foundation for other studies to further investigate this topic.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.