ArticleScientific reports2017
Relation between characteristics of carotid atherosclerotic plaques and brain white matter hyperintensities in asymptomatic patients.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03333330 (Non Invasive Vascular Imaging Combined With Systemic Biomarkers and Brain Magnetic Resonance Imaging for Identification of Asymptomatic Patients With Unstable Carotid Atherosclerosis), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Non Invasive Vascular Imaging Combined With Systemic Biomarkers and Brain Magnetic Resonance Imaging for Identification of Asymptomatic Patients With Unstable Carotid Atherosclerosis
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- White matter hyperintensities and their subtypes in patients with carotid artery stenosis: a systematic review and meta-analysis.BMJ open · 2018Pooled it
- Diagnosis of extracranial carotid stenosis by MRA of the brain.Scientific reports · 2021Trial
- Relationship Between Carotid Artery Anatomy and Geometry and White Matter Hyperintensities and Accompanying Comorbid Factors.Tomography (Ann Arbor, Mich.) · 2026Article
- Napkin-ring sign plaques are associated with cerebral small vessel disease.European journal of medical research · 2025Article
- Pathophysiological link between carotid atherosclerosis and cerebral white matter lesions.Scientific reports · 2025Article
- White matter hyperintensity volume modifies the association between CSF vascular inflammatory biomarkers and regional FDG-PET along the Alzheimer's disease continuum.Neurobiology of aging · 2023Article
- Asymmetry of Lacunae between Brain Hemispheres Is Associated with Atherosclerotic Occlusions of Middle Cerebral Artery.Brain sciences · 2023Article
- Perforating artery flow velocity and pulsatility in patients with carotid occlusive disease. A 7 tesla MRI study.Cerebral circulation - cognition and behavior · 2022Article
- Microstructural Alterations Analogous to Accelerated Aging of the Cerebral Cortex in Carotid Occlusive Disease.Clinical neuroradiology · 2021Article
- Silent brain infarcts and white matter lesions in patients with asymptomatic carotid stenosis.Acta neurologica Belgica · 2021Article
- Extent and characteristics of carotid plaques and brain parenchymal loss in asymptomatic patients with no indication for revascularization.International journal of cardiology. Heart & vasculature · 2020Article
- The Asymmetry of White Matter Hyperintensity Burden Between Hemispheres Is Associated With Intracranial Atherosclerotic Plaque Enhancement Grade.Frontiers in aging neuroscience · 2020Article
- Altered brain volume and its relationship to characteristics of carotid plaques in asymptomatic patients.Medicine · 2018Article
- Carotid artery plaque uptake ofInternational journal of cardiology. Heart & vasculature · 2018Article
- Cardiovascular disease and brain health: Focus on white matter hyperintensities.International journal of cardiology. Heart & vasculature · 2018Review
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
White matter hyperintensities (WMH) can be incidentally found in patients with carotid atherosclerosis on brain magnetic resonance imaging (MRI). We investigated the relationship between WMH and characteristics of carotid plaques in asymptomatic patients without indication for carotid revascularization. We prospectively screened 235 consecutive patients with carotid stenosis <70%. After excluding patients with confounding causes of cerebral damage, 67 asymptomatic patients underwent carotid computed tomography angiography (CTA), contrast-enhanced ultrasound and brain MRI. Number and quantitative measurement of volume of WMH were associated with history of resistant hypertension, degree of stenosis (Doppler) and presence of an ulcerated plaque at CTA (p < 0.05). At multivariate regression analysis, resistant hypertension was independently associated with both number and volume of WMH, presence of an ulcer with number of WMH and degree of stenosis with WMH volume (p < 0.05), although WMH were equally distributed in both hemispheres irrespectively of plaque side. In conclusion, in asymptomatic patients with carotid plaques <70%, a higher burden of WMHs is associated with history of resistant hypertension that could be the expression of microvascular damage. Stenosis severity and presence of plaque ulceration are also associated with WMH burden although their causative relation is not supported by the bilateral distribution of WMH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.