ArticleScientific reports2017
Cortical and trabecular morphology is altered in the limb bones of mice artificially selected for faster skeletal growth.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- Early-life exercise effects on Achilles tendon in mice selectively bred for high voluntary wheel-running behavior.Physiological reports · 2025Article
- Endplate remodeling: a key indicator of cigarette smoke exposure-induced intervertebral disc degeneration in a male rat model.JBMR plus · 2025Article
- IĸB Protein BCL3 as a Controller of Osteogenesis and Bone Health.Arthritis & rheumatology (Hoboken, N.J.) · 2023Article
- Identification of stages of amelogenesis in the continuously growing mandiblular incisor of C57BL/6J male mice throughout life using molar teeth as landmarks.Frontiers in physiology · 2023Article
- Effects of oral losartan administration on homeostasis of articular cartilage and bone in a rabbit model.Bone reports · 2022Article
- Article
- Peak trabecular bone microstructure predicts rate of estrogen-deficiency-induced bone loss in rats.Bone · 2021Article
- A NaFrontiers in cell and developmental biology · 2021Article
- Three-dimensional microstructures of the intracortical canals in the animal model of osteoporosis.Anatomy & cell biology · 2020Article
- Ontogenetic changes to bone microstructure in an archaeologically derived sample of human ribs.Journal of anatomy · 2020Article
- Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone strength is influenced by mineral density and macro- and microstructure. Research into factors that contribute to bone morphology and strength has focused on genetic, environmental and morphological factors (e.g., body mass index), but little is known regarding the impact of rates of skeletal elongation on adult skeletal morphology and strength. Using micro-CT, we examined the impact of rates of skeletal elongation on bone cortical and trabecular morphology, and on rates of estrogen-dependent bone loss in the tibia in CD-1 mice, and in mice with accelerated skeletal growth (Longshanks). Groups of adult mice (n = 7/group) were subjected to ovariectomy or sham surgeries, scanned for 6 weeks, and indices of bone morphology were collected. Results show that Longshanks mice had significantly less trabecular bone at skeletal maturity, characterized by fewer, thinner trabeculae, and furthermore lost trabecular bone more slowly in response to ovariectomy. Artificial selection for rapid skeletal growth relative to somatic growth thus had a significant impact on trabecular bone morphology in Longshanks. Our data do not unequivocally demonstrate a causal relationship between rapid bone growth and reduced trabecular bone quality, but suggest that rapid linear bone growth may influence the risk of cancellous bone fragility.
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