ArticleScientific reports2017
A new red cell index and portable RBC analyzer for screening of iron deficiency and Thalassemia minor in a Chinese population.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 33 citations in OpenAlex.
- Prognostic value of hemoglobin-to-red cell distribution width ratio and inflammation markers in colorectal cancer.World journal of gastrointestinal oncology · 2025Article
- A comprehensive case study of deep learning on the detection of alpha thalassemia and beta thalassemia using public and private datasets.Scientific reports · 2025Article
- Multi-criteria decision making to validate performance of RBC-based formulae to screenBMC medical informatics and decision making · 2024Article
- Magnitude and morphological types of anemia differ by age among under five children: A facility-based study.Heliyon · 2022Article
- Application of Bayesian Decision Tree in Hematology Research: Differential Diagnosis ofComputational and mathematical methods in medicine · 2021Article
- Nanometer precise red blood cell sizing using a cost-effective quantitative dark field imaging system.Biomedical optics express · 2020Article
- Prognostic value of baseline hemoglobin-to-red blood cell distribution width ratio in small cell lung cancer: A retrospective analysis.Thoracic cancer · 2020Article
- Refractive index of human red blood cells between 290 nm and 1100 nm determined by optical extinction measurements.Scientific reports · 2019Article
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Authors and funding
6 authors at 4 institutions in 4 countries.
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Abstract
Anemia is a widespread public health problem with 1/4 ~1/3 of the world's population being affected. In Southeast Asia, Thalassemia trait (TT) and iron deficiency anemia (IDA) are the two most common anemia types and can have a serious impact on quality of life. IDA patients can be treated with iron supplementation, yet TT patients have diminished capacity to process iron. Therefore, distinguishing between types of anemia is essential for effective diagnosis and treatment. Here, we present two advances towards low-cost screening for anemia. First: a new red-cell-based index, Joint Indicator A, to discriminate between IDA, TT, and healthy children in a Chinese population. We collected retrospective data from 384 Chinese children and used discriminant function analysis to determine the best analytic function to separate healthy and diseased groups, achieving 94% sensitivity and 90% specificity, significantly higher than reported indices. This result is achieved using only three red cell parameters: mean cell volume (MCV), red cell distribution width (RDW) and mean cell hemoglobin concentration (MCHC). Our second advance: the development of a low cost, portable red cell analyzer to measure these parameters. Taken together, these two results may help pave the way for widespread screening for nutritional and genetic anemias.
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