Evidence map›Paper›PMID 28874751›Full record

ArticleScientific reports2017

Disease mutations reveal residues critical to the interaction of P4-ATPases with lipid substrates.

Rasmus H Gantzel, Louise S Mogensen, Stine A Mikkelsen, Bente Vilsen, Robert S Molday, Anna L Vestergaard, Jens P Andersen

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Ultrafast Dynamics at Lipid-Water Interfaces.Accounts of chemical research · 2020
    Article
  8. Review
  9. Article
  10. Phosphatidylserine flipping by the P4-ATPase ATP8A2 is electrogenic.Proceedings of the National Academy of Sciences of the United States of America · 2019
    Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Rasmus H GantzelDepartment of Biomedicine, Aarhus University, Ole Worms Allé 4, Bldg. 1160, DK-8000, Aarhus C, Denmark.
Louise S MogensenDepartment of Biomedicine, Aarhus University, Ole Worms Allé 4, Bldg. 1160, DK-8000, Aarhus C, Denmark.
Stine A MikkelsenDepartment of Biomedicine, Aarhus University, Ole Worms Allé 4, Bldg. 1160, DK-8000, Aarhus C, Denmark.
Bente VilsenDepartment of Biomedicine, Aarhus University, Ole Worms Allé 4, Bldg. 1160, DK-8000, Aarhus C, Denmark.
Robert S MoldayDepartment of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, V6T 1Z3, Canada.
Anna L VestergaardDepartment of Biomedicine, Aarhus University, Ole Worms Allé 4, Bldg. 1160, DK-8000, Aarhus C, Denmark.ORCID 0000-0001-8716-1111
Jens P AndersenDepartment of Biomedicine, Aarhus University, Ole Worms Allé 4, Bldg. 1160, DK-8000, Aarhus C, Denmark. jpa@biomed.au.dk.ORCID 0000-0003-0654-4300
Aarhus University · DKUniversity of British Columbia · CAUniversity of Copenhagen · DK

Funding

STRUCTURE/FUNCTION OF ROS PLASMA MEMBRANE PROTEINSR01EY002422 · NEI · UNIVERSITY OF BRITISH COLUMBIA · PI MOLDAY, ROBERT S · 1985 to 2017
$3.5M
NEI NIH HHS R01 EY002422
6 · The paper itself

Abstract

Phospholipid flippases (P

Indexed as

Genetic Predisposition to DiseaseLipid MetabolismMutationAdenosine TriphosphatasesAnimalsBinding SitesCattleEnzyme ActivationGene ExpressionModels, MolecularPhospholipidsPhospholipid Transfer ProteinsProtein BindingProtein ConformationStructure-Activity RelationshipSubstrate SpecificityAdenosine TriphosphatasesPhospholipidsPhospholipid Transfer Proteins

Identifiers

PMID28874751
PMCPMC5585164
OpenAlexW2751623674

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.