ArticleScientific reports2017
Structural and pharmacological basis for the induction of mitochondrial biogenesis by formoterol but not clenbuterol.
Erratum issuedOpen access · goldAbstract read
In one paragraph
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 22 papers.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Beta 2-adrenergic pathway combats Alzheimer's disease: Restoring cognition and synaptic integrity.Neural regeneration research · 2026Article
- Norepinephrine regulates hippocampal mitochondrial biogenesis via β2-adrenergic receptor signaling and PGC-1α.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Beta 2 adrenergic receptor agonists as a treatment for metabolic dysfunction-associated steatohepatitis (MASH).npj metabolic health and disease · 2026Article
- Enhancing Mitochondrial Function Through Pharmacological Modification: A Novel Approach to Mitochondrial Transplantation in a Sepsis Model.Biomedicines · 2025Article
- Formoterol promotes mitochondrial biogenesis, improves liver regeneration, and suppresses liver injury and inflammation after liver resection in mice with endotoxemia.International journal of physiology, pathophysiology and pharmacology · 2025Article
- Serotonin regulation of mitochondria in kidney diseases.Pharmacological research · 2024Review
- Targeting mitochondria with antioxidant nutrients for the prevention and treatment of postweaning diarrhea in piglets.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2023Review
- From Physiology to Pathology: The Role of Mitochondria in Acute Kidney Injuries and Chronic Kidney Diseases.Kidney diseases (Basel, Switzerland) · 2023Review
- Therapeutic Potential Targeting Podocyte Mitochondrial Dysfunction in Focal Segmental Glomerulosclerosis.Kidney diseases (Basel, Switzerland) · 2023Review
- The regulatory role of adipocyte mitochondrial homeostasis in metabolism-related diseases.Frontiers in physiology · 2023Review
- Kinase perturbations redirect mitochondrial function in cancer.Bioenergetics communications · 2022Article
- Mitochondria in Diabetic Kidney Disease.Cells · 2021Review
- Formoterol PLGA-PEG Nanoparticles Induce Mitochondrial Biogenesis in Renal Proximal Tubules.The AAPS journal · 2021Article
- βAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2021Review
- Targeting Mitochondrial Biogenesis with Polyphenol Compounds.Oxidative medicine and cellular longevity · 2021Review
- Activation of βArchives of pharmacal research · 2021Review
- Extracellular signal-regulated kinase 1/2 regulates NAD metabolism during acute kidney injury through microRNA-34a-mediated NAMPT expression.Cellular and molecular life sciences : CMLS · 2020Article
- Mitochondrial biogenesis: An update.Journal of cellular and molecular medicine · 2020Review
- Comprehensive assessment of mitochondrial respiratory function in freshly isolated nephron segments.American journal of physiology. Renal physiology · 2020Article
- Elucidation of cGMP-dependent induction of mitochondrial biogenesis through PKG and p38 MAPK in the kidney.American journal of physiology. Renal physiology · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 2 institutions in 1 country.
Robert B CameronDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, 85721, USA.ORCID http://orcid.org/0000-0002-0439-8947
Yuri K PetersonDepartment of Drug Discovery and Biomedical Sciences, College of Pharmacy, Medical University of South Carolina, MSC139, 70 President St., Charleston, SC, 29425-8906, USA.
Craig C BeesonDepartment of Drug Discovery and Biomedical Sciences, College of Graduate Studies, Medical University of South Carolina, Charleston, SC, 29425, USA.
Rick G SchnellmannDepartment of Pharmacology and Toxicology, College of Pharmacy, University of Arizona, Tucson, AZ, 85721, USA. schnell@pharmacy.arizona.edu.
Medical University of South Carolina · USUniversity of Arizona · US
Funding
SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALINGP20GM103542 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TEW, KENNETH D. · 2012 to 2020
$20.2MTRAINING TO IMPROVE CARDIOVASCULAR THERAPIEST32HL007260 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI MENICK, DONALD R. · 1985 to 2021
$11.1MTRAINING PROGRAM FOR MEDICAL SCIENTISTST32GM008716 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DEMORE, NANCY · 1999 to 2024
$9.3MMitochondrial Biogenesis Promotes Recovery From Oxidant InjuryR01GM084147 · NIGMS · UNIVERSITY OF ARIZONA · PI SCHNELLMANN, RICK G · 2008 to 2016
$2.4MElucidation of Beta-2 Adrenergic Receptor Pathways Leading to Mitochondrial BiogenesisF30DK104550 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI CAMERON, ROBERT BRUCE · 2014 to 2018
$224k5-HT Stimulation of Mitochondrial Biogenesis and Acute Kidney InjuryI01BX000851 · VA · SOUTHERN ARIZONA VA HEALTH CARE SYSTEM · PI SCHNELLMANN, RICK G · 2011 to 2025
–BLRD VA I01 BX000851NHLBI NIH HHS T32 HL007260NIDDK NIH HHS F30 DK104550NIGMS NIH HHS P20 GM103542NIGMS NIH HHS R01 GM084147NIGMS NIH HHS T32 GM008716
Abstract
Mitochondrial dysfunction is associated with numerous acute and chronic degenerative diseases. The beta-2 adrenergic receptor (β
Indexed as
Organelle BiogenesisAnimalsCell RespirationClenbuterolCyclic GMPEpithelial CellsFormoterol FumarateKidney Tubules, ProximalMitochondriaModels, MolecularMolecular ConformationOxygen ConsumptionPhosphatidylinositol 3-KinasesPhosphorylationProto-Oncogene Proteins c-aktRabbitsClenbuterolCyclic GMPFormoterol FumaratePhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-akt
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.