Evidence map›Paper›PMID 28874733›Full record

ArticleScientific reports2017

Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability.

Thomas Briston, Malcolm Roberts, Sian Lewis, Ben Powney, James M Staddon, Gyorgy Szabadkai, Michael R Duchen

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.

0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

80 citing papers in PubMed, 142 citations in OpenAlex.

  1. Review
  2. Article
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  5. Camelliasaponin B1, a Saponin fromAntioxidants (Basel, Switzerland) · 2026
    Article
  6. Phenotypic CRISPR screens identify NLRX1 as an essential activator of the human mitochondrial permeability transition.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Article
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  11. Gelated microvesicle-mediated delivery of mesenchymal stem cell mitochondria for the treatment of myocardial infarction.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Review
  13. Mitochondrial Dysfunction in Cardiovascular Diseases.International journal of molecular sciences · 2025
    Review
  14. Acute CClJournal of bioenergetics and biomembranes · 2025
    Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

20 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Thomas BristonNeurology Innovation Centre, Hatfield Research Laboratories, Eisai Ltd., Hatfield, UK. thomas_briston@eisai.net.
Malcolm RobertsNeurology Innovation Centre, Hatfield Research Laboratories, Eisai Ltd., Hatfield, UK.
Sian LewisNeurology Innovation Centre, Hatfield Research Laboratories, Eisai Ltd., Hatfield, UK.
Ben PowneyNeurology Innovation Centre, Hatfield Research Laboratories, Eisai Ltd., Hatfield, UK.
James M StaddonNeurology Innovation Centre, Hatfield Research Laboratories, Eisai Ltd., Hatfield, UK.
Gyorgy SzabadkaiDepartment of Cell and Developmental Biology, Consortium for Mitochondrial Research, University College London, London, UK.ORCID 0000-0002-3006-3577
Michael R DuchenDepartment of Cell and Developmental Biology, Consortium for Mitochondrial Research, University College London, London, UK.ORCID 0000-0003-2548-4294
Eisai (United Kingdom) · GBUniversity College London · GBUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitochondrial Ca

Indexed as

Ion Channel GatingAnimalsCalciumCell RespirationElectron Transport Complex IEnergy MetabolismFemaleHydrogen PeroxideMembrane Potential, MitochondrialMitochondriaMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreNADOxygen ConsumptionRatsReactive Oxygen SpeciesCalciumElectron Transport Complex IHydrogen PeroxideMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreNADReactive Oxygen SpeciesSuccinic Acid

Identifiers

PMID28874733
PMCPMC5585167
OpenAlexW2753044726

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.