ArticleScientific reports2017
A mutation in the melon Vacuolar Protein Sorting 41prevents systemic infection of Cucumber mosaic virus.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Introgression line libraries in melon (Molecular breeding : new strategies in plant improvement · 2026Review
- Article
- Cloning and functional analysis of qCmr2.1, a novel gene for Cucumber mosaic virus resistance in Capsicum frutescens.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Genome-wide association studies to assess genetic factors controlling cucumber resistance to CABYV and CMV in crop fields and the attractiveness for theirHorticulture research · 2025Article
- Comprehensive proteomic profiling of Cucumber mosaic virus infection: identifying key proteins and pathways involved in resistance and susceptibility in melon.BMC plant biology · 2025Article
- Possibility of genome editing for melon breeding.Breeding science · 2024Article
- Insights into the early transcriptomic response against watermelon mosaic virus in melon.BMC plant biology · 2024Article
- Article
- A Novel Introgression Line Library Derived from a Wild Melon Gives Insights into the Genetics of Melon Domestication, Uncovering New Genetic Variability Useful for Breeding.International journal of molecular sciences · 2023Article
- Mutations in CmVPS41 controlling resistance to cucumber mosaic virus display specific subcellular localization.Plant physiology · 2023Article
- Vegetable biology and breeding in the genomics era.Science China. Life sciences · 2023Review
- Fruit Morphology and Ripening-Related QTLs in a Newly Developed Introgression Line Collection of the Elite Varieties 'Védrantais' and 'Piel de Sapo'.Plants (Basel, Switzerland) · 2022Article
- Fine-mapping and identification of a candidate gene controlling seed coat color in melon (Cucumis melo L. var. chinensis Pangalo).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2022Article
- Membrane Trafficking Proteins: A New Target to Identify Resistance to Viruses in Plants.Plants (Basel, Switzerland) · 2021Review
- A novel introgression line collection to unravel the genetics of climacteric ripening and fruit quality in melon.Scientific reports · 2021Article
- A single resistance factor to solve vineyard degeneration due to grapevine fanleaf virus.Communications biology · 2021Article
- Resistance to Cucumber Green Mottle Mosaic Virus inPlants (Basel, Switzerland) · 2021Article
- A helitron-induced RabGDIα variant causes quantitative recessive resistance to maize rough dwarf disease.Nature communications · 2020Article
- Editorial: Translational Research for Cucurbit Molecular Breeding: Traits, Markers, and Genes.Frontiers in plant science · 2020Article
- A Major QTL Located in Chromosome 8 ofFrontiers in plant science · 2020Article
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10 authors.
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Abstract
In the melon exotic accession PI 161375, the gene cmv1, confers recessive resistance to Cucumber mosaic virus (CMV) strains of subgroup II. cmv1 prevents the systemic infection by restricting the virus to the bundle sheath cells and impeding viral loading to the phloem. Here we report the fine mapping and cloning of cmv1. Screening of an F2 population reduced the cmv1 region to a 132 Kb interval that includes a Vacuolar Protein Sorting 41 gene. CmVPS41 is conserved among plants, animals and yeast and is required for post-Golgi vesicle trafficking towards the vacuole. We have validated CmVPS41 as the gene responsible for the resistance, both by generating CMV susceptible transgenic melon plants, expressing the susceptible allele in the resistant cultivar and by characterizing CmVPS41 TILLING mutants with reduced susceptibility to CMV. Finally, a core collection of 52 melon accessions allowed us to identify a single amino acid substitution (L348R) as the only polymorphism associated with the resistant phenotype. CmVPS41 is the first natural recessive resistance gene found to be involved in viral transport and its cellular function suggests that CMV might use CmVPS41 for its own transport towards the phloem.
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