ArticleScientific reports2017
Comprehensive transcriptome profiling of Salvia miltiorrhiza for discovery of genes associated with the biosynthesis of tanshinones and phenolic acids.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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54 citing papers in PubMed, 118 citations in OpenAlex.
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- Synthesis and biological activity study of tanshinone I-pyridinium salt derivatives.Natural products and bioprospecting · 2025Article
- Phytochemical profiling, antioxidant potential, and UHPLC-HRMS analysis of Phlomis genus aerial parts for therapeutic applications.Scientific reports · 2025Article
- Mining the Candidate Transcription Factors Modulating Tanshinones' and Phenolic Acids' Biosynthesis Under Low Nitrogen Stress inInternational journal of molecular sciences · 2025Article
- Identification of a central regulator of ginkgolide biosynthesis inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Comparative transcriptomic analysis and genome-wide identification provide insights into the potential role of fungal-responsive MAPK cascade genes in tanshinone accumulation inFrontiers in plant science · 2025Article
- Decoding the mystery: AI-assisted bioinformatics and functional genomics technologies in medicinal plants.Frontiers in plant science · 2025Article
- Screening of native wild Salvia nemorosa populations for chemical compositions, antioxidant activity and UHPLC-HRMS profiling.Scientific reports · 2024Article
- Genome-Wide Identification and Expression Analysis of Carotenoid Cleavage Dioxygenase Genes inInternational journal of molecular sciences · 2024Article
- Content Determination and Chemical Clustering Analysis of Tanshinone and Salvianolic Acid inMetabolites · 2024Article
- Biosynthesis and signal transduction of plant growth regulators and their effects on bioactive compound production in Salvia miltiorrhiza (Danshen).Chinese medicine · 2024Review
- Genome-Wide Identification and Expression Analysis of Sucrose Nonfermenting 1-Related Protein Kinase (Plants (Basel, Switzerland) · 2024Article
- Genome-Wide Identification and Characterization of thePlants (Basel, Switzerland) · 2024Article
- A chromosome-level genome assembly of anesthetic drug-producing Anisodus acutangulus provides insights into its evolution and the biosynthesis of tropane alkaloids.Plant communications · 2024Article
- Mining of disease-resistance genes inFrontiers in genetics · 2024Article
- Jasmonic acid regulates the biosynthesis of medicinal metabolites via the JAZ9-MYB76 complex inHorticulture research · 2023Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tanshinones and phenolic acids are crucial bioactive compounds biosynthesized in Salvia miltiorrhiza. Methyl jasmonate (MeJA) is an effective elicitor to enhance the production of phenolic acids and tanshinones simultaneously, while yeast extract (YE) is used as a biotic elicitor that only induce tanshinones accumulation. However, little was known about the different molecular mechanism. To identify the downstream and regulatory genes involved in tanshinone and phenolic acid biosynthesis, we conducted comprehensive transcriptome profiling of S. miltiorrhiza hairy roots treated with either MeJA or YE. Total 55588 unigenes were assembled from about 1.72 billion clean reads, of which 42458 unigenes (76.4%) were successfully annotated. The expression patterns of 19 selected genes in the significantly upregulated unigenes were verified by quantitative real-time PCR. The candidate downstream genes and other cytochrome P450s involved in the late steps of tanshinone and phenolic acid biosynthesis pathways were screened from the RNA-seq dataset based on co-expression pattern analysis with specific biosynthetic genes. Additionally, 375 transcription factors were identified to exhibit a significant up-regulated expression pattern in response to induction. This study can provide us a valuable gene resource for elucidating the molecular mechanism of tanshinones and phenolic acids biosynthesis in hairy roots of S. miltiorrhiza.
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