ArticleScientific reports2017
NF-κB inhibitors, unique γ-pyranol-γ-lactams with sulfide and sulfoxide moieties from Hawaiian plant Lycopodiella cernua derived fungus Paraphaeosphaeria neglecta FT462.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Fusaric Acid Analogs and Dimers from Marine-DerivedJournal of natural products · 2026Article
- Sulfur-Containing Microbial Natural Products and Their Role in Communal Interactions.Journal of natural products · 2025Review
- Investigation of the genetic diversity of gut mycobiota of the wild and laboratory mice.Microbiology spectrum · 2025Article
- Identification and Characterization of a Plant Endophytic FungusJournal of fungi (Basel, Switzerland) · 2024Article
- Article
- Sulfur-Containing Compounds from Endophytic Fungi: Sources, Structures and Bioactivities.Journal of fungi (Basel, Switzerland) · 2022Review
- Polyketides, diketopiperazines and an isochromanone from the marine-derived fungal strain Fusarium graminearum FM1010 from Hawaii.Phytochemistry · 2022Article
- Discovery of unusual dimeric piperazyl cyclopeptides encoded by aProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Aspochalasin H1: A New Cyclic Aspochalasin from Hawaiian Plant-Associated Endophytic FungusMolecules (Basel, Switzerland) · 2021Article
- New Alkaloids From a Hawaiian Fungal StrainFrontiers in chemistry · 2021Article
- Tryptoquivalines W and X, two new compounds from a Hawaiian fungal strain and their biological activities.Tetrahedron letters · 2020Article
- An Unusual Benzoisoquinoline-9-one Derivative and Other Related Compounds with Antiproliferative Activity from Hawaiian Endophytic FungusMolecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
Abstract
LC-UV/MS-based metabolomic analysis of the Hawaiian endophytic fungus Paraphaeosphaeria neglecta FT462 led to the identification of four unique mercaptolactated γ-pyranol-γ-lactams, paraphaeosphaerides E-H (1-4) together with one γ-lactone (5) and the methyl ester of compound 2 (11). The structures of the new compounds (1-5 and 11) were elucidated through the analysis of HRMS and NMR spectroscopic data. The absolute configuration was determined by chemical reactions with sodium borohydride, hydrogen peroxide, α-methoxy-α-(trifluoromethyl)phenylacetyl chlorides (Mosher reagents), and DP4 + NMR calculations. All the compounds were tested against STAT3, A2780 and A2780cisR cancer cell lines, E. coli JW2496, and NF-κB. Compounds 1 and 3 strongly inhibited NF-κB with IC
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