Evidence map›Paper›PMID 28874682›Full record

ArticleScientific reports2017

Hydrogen peroxide dynamics in subcellular compartments of malaria parasites using genetically encoded redox probes.

Mahsa Rahbari, Stefan Rahlfs, Jude M Przyborski, Anna Katharina Schuh, Nicholas H Hunt, David A Fidock, Georges E Grau, Katja Becker

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. In Vivo Imaging with Genetically Encoded Redox Biosensors.International journal of molecular sciences · 2020
    Review
  6. Article
  7. Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Mahsa RahbariBiochemistry and Molecular Biology, Interdisciplinary Research Center, Justus Liebig University Giessen, 35392, Giessen, Germany.
Stefan RahlfsBiochemistry and Molecular Biology, Interdisciplinary Research Center, Justus Liebig University Giessen, 35392, Giessen, Germany.
Jude M PrzyborskiDepartment of Parasitology, Philipps University Marburg, 35043, Marburg, Germany.ORCID 0000-0002-3494-7767
Anna Katharina SchuhBiochemistry and Molecular Biology, Interdisciplinary Research Center, Justus Liebig University Giessen, 35392, Giessen, Germany.
Nicholas H HuntDiscipline of Pathology, Sydney Medical School and Bosch Institute, University of Sydney, Medical Foundation Building (K25), Camperdown, NSW, 2050, Australia.
David A FidockDepartment of Microbiology and Immunology and Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, 10032, USA.ORCID 0000-0001-6753-8938
Georges E GrauDiscipline of Pathology, Sydney Medical School and Bosch Institute, University of Sydney, Medical Foundation Building (K25), Camperdown, NSW, 2050, Australia.
Katja BeckerBiochemistry and Molecular Biology, Interdisciplinary Research Center, Justus Liebig University Giessen, 35392, Giessen, Germany. katja.becker@uni-giessen.de.
Justus-Liebig-Universität Gießen · DEThe University of Sydney · AUColumbia University Irving Medical Center · USPhilipps University of Marburg · DE

Funding

Role of pfcrt in chloroquine resistance in P. falciparumR01AI050234 · NIAID · YESHIVA UNIVERSITY · PI FIDOCK, DAVID A · 2001 to 2015
$5.7M
Defining the Role of PfCRT and PfMDR1 as Pleiotropic Mediators of Plasmodium falciparum Multidrug ResistanceR37AI050234 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock · 2018 to 2026
$4.4M
Defining P. falciparum resistance to artemisinin-based combination therapiesR01AI109023 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FIDOCK, DAVID A · 2014 to 2025
$4.4M
NIAID NIH HHS R01 AI050234NIAID NIH HHS R01 AI109023NIAID NIH HHS R37 AI050234
6 · The paper itself

Abstract

Redox balance is essential for the survival, growth and multiplication of malaria parasites and oxidative stress is involved in the mechanism of action of many antimalarial drugs. Hydrogen peroxide (H

Indexed as

Oxidation-ReductionAntimalarialsBiosensing TechniquesGene ExpressionGenes, ReporterHydrogen PeroxideMalariaMolecular ImagingMolecular ProbesPlasmodiumAntimalarialsHydrogen PeroxideMolecular Probes

Identifiers

PMID28874682
PMCPMC5585161
OpenAlexW2753179086

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.