ArticleNature communications2017
Emergence of native peptide sequences in prebiotic replication networks.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Tailored Phosphate Leaving Groups Direct Pathway-Dependent Self-Assembly.Journal of the American Chemical Society · 2026Article
- Regulating Promiscuous Catalysis via Substrate-Induced Transient Assembly.Angewandte Chemie (International ed. in English) · 2026Article
- The Evolution of Functional Amyloids and Their Impact on Host-Microbe Interactions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Origin of life: β-sheet amyloid conformers as the primordial functional polymers on the early Earth and their role in the emergence of complex dynamic networks.FEBS letters · 2025Review
- Prebiotic Peptide Synthesis: How Did Longest Peptide Appear?Journal of molecular evolution · 2025Review
- Amino acid analogues provide multiple plausible pathways to prebiotic peptides.Journal of the Royal Society, Interface · 2024Review
- Theoretical perspective on synthetic man-made life: Learning from the origin of life.Quantitative biology (Beijing, China) · 2023Review
- Light-Fueled Primitive Replication and Selection in Biomimetic Chemical Systems.Journal of the American Chemical Society · 2023Article
- Why we are made of proteins and nucleic acids: Structural biology views on extraterrestrial life.Biophysics and physicobiology · 2023Article
- Thioesters provide a plausible prebiotic path to proto-peptides.Nature communications · 2022Article
- Prebiotically Plausible Autocatalytic Peptide Amyloids.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- From amino acid mixtures to peptides in liquid sulphur dioxide on early Earth.Nature communications · 2021Article
- Primitive selection of the fittest emerging through functional synergy in nucleopeptide networks.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Darwinian properties and their trade-offs in autocatalytic RNA reaction networks.Nature communications · 2021Article
- Covalent Linkage and Macrocylization Preserve and Enhance Synergistic Interactions in Catalytic Amyloids.Chembiochem : a European journal of chemical biology · 2021Article
- From self-replication to replicator systems en route to de novo life.Nature reviews. Chemistry · 2020Review
- Spontaneous Emergence of Self-Replicating Molecules Containing Nucleobases and Amino Acids.Journal of the American Chemical Society · 2020Article
- Chemistry of Homocysteine Thiolactone in A Prebiotic Perspective.Life (Basel, Switzerland) · 2019Article
- Progress in synthesizing protocells.Experimental biology and medicine (Maywood, N.J.) · 2019Review
- Reductionist Approach in Peptide-Based Nanotechnology.Annual review of biochemistry · 2018Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Biopolymer syntheses in living cells are perfected by an elaborate error correction machinery, which was not applicable during polymerization on early Earth. Scientists are consequently striving to identify mechanisms by which functional polymers were selected and further amplified from complex prebiotic mixtures. Here we show the instrumental role of non-enzymatic replication in the enrichment of certain product(s). To this end, we analyzed a complex web of reactions in β-sheet peptide networks, focusing on the formation of specific intermediate compounds and template-assisted replication. Remarkably, we find that the formation of several products in a mixture is not critically harmful, since efficient and selective template-assisted reactions serve as a backbone correction mechanism, namely, for keeping the concentration of the peptide containing the native backbone equal to, or even higher than, the concentrations of the other products. We suggest that these findings may shed light on molecular evolution processes that led to current biology.The synthesis of biopolymers in living cells is perfected by complex machinery, however this was not the case on early Earth. Here the authors show the role of non-enzymatic replication in the enrichment of certain products within prebiotically relevant mixtures.
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