ArticleProceedings of the National Academy of Sciences of the United States of America2017
Dual role of mitochondria in producing melatonin and driving GPCR signaling to block cytochrome c release.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 227 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
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227citing papers in PubMed, 2 pooled it
16.9field-weighted citation impact, top 1% of its field
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Who cites it
227 citing papers in PubMed, 2 syntheses or guidelines pooled it, 399 citations in OpenAlex.
- Physiological relevance of autocrine melatonin signaling in pineal and extrapineal sites: a systematic review.Function (Oxford, England) · 2026Pooled it
- A Clinical, Pharmacological, and Formulation Evaluation of Melatonin in the Treatment of Ocular Disorders-A Systematic Review.International journal of molecular sciences · 2024Pooled it
- Infantile Cocktail of Erythropoietin and Melatonin Restores Gait in Adult Rats with Preterm Brain Injury.Developmental neuroscience · 2022Trial
- Resurrection biology: Melatonin as a modulator of anastasis (Review).Molecular medicine reports · 2026Review
- Spatiotemporal modeling of GPCR signaling: The role of endosomal dynamics and receptor recycling.PLoS computational biology · 2026Article
- Oncogenic Gα signaling requires AP-3-dependent recruitment to the endolysosomal compartment.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Molecular and Cellular Mechanisms of Melatonin: From Physiological Actions to Clinical Applications in Reproductive Medicine.International journal of molecular sciences · 2026Review
- Review
- Unveiling melatonin's multifaceted actions against ferroptotic neurotoxicity in ischemic stroke.Toxicology reports · 2026Review
- Metabolic reprogramming is critical to microglial activation in Huntington's disease.JCI insight · 2026Article
- Melatonin Targets Mitochondrial Redox Homeostasis: Optimizing the Intracellular Microenvironment.International journal of molecular sciences · 2026Review
- Cell Signaling by Tryptophan Catabolism.Biochemistry · 2026Review
- Subcellular Redistribution of Endomembrane GPR15 Promotes NAD+-Mediated Metabolic Reprogramming and Boosts 5-FU Chemosensitivity in Colorectal Cancer.Cancer research · 2026Article
- Cell-internal autocrine receptor inactivation supports maintenance of mating-type identity in yeast.Science advances · 2026Article
- Melatonin and mitochondrial protection in cardiac ischemia-reperfusion injury: mechanisms, evidence and translational perspectives.Basic research in cardiology · 2026Review
- Melatonin May Improve Post-Thaw Sperm Motility inAntioxidants (Basel, Switzerland) · 2026Article
- Tryptophan metabolism alterations in neurological and psychiatric diseases: Molecular mechanisms and pharmacological targets.Metabolic brain disease · 2026Review
- Optimizing Brain Biology Through Near-Infrared-Induced Mitochondrial Melatonin Synthesis: A Hypothesis Paper.Cureus · 2026Review
- GPCR-Mediated Cell Intelligence: A Potential Mechanism for Survival and Long-Term Health.Current issues in molecular biology · 2026Review
- Melatonin as a Guardian of Mitochondria: Mechanisms and Therapeutic Potential in Neurodegenerative Diseases.Biology · 2026Review
167 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
36 authors at 6 institutions in 4 countries.
Yalikun SuofuNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213.
Wei LiNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213.
Frédéric G Jean-AlphonseLaboratory for G-Protein Coupled Receptor Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261.
Jiaoying JiaNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213.
Nicolas K KhattarNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213.ORCID 0000-0002-5077-9804
Jiatong LiNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213.
Sergei V BaranovNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213.
Daniela LeronniNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213.
Amanda C MihalikNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213.
Yanqing HeNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213.
Erika CeconInserm, U1016, Institut Cochin, 75014 Paris, France.
Vanessa L WehbiLaboratory for G-Protein Coupled Receptor Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261.
JinHo KimNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213.
Brianna E HeathNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213.
Oxana V BaranovaNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213.
Xiaomin WangNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213.
Matthew J GableNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213.
Eric S KretzNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213.
Giulietta Di BenedettoNeuroscience Institute, Italian National Research Council, 35121 Padova, Italy.
Timothy R LezonDrug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261.
Lisa M FerrandoNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213.
Timothy M LarkinNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213.
Mara SullivanCenter for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA 15213.
Svitlana YablonskaNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213.
Jingjing WangNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213.
M Beth MinnighSmall Molecule Biomarker Core, University of Pittsburgh, Pittsburgh, PA 15213.
Gérald GuillaumetInstitut de Chimie Organique et Analytique, Universite d'Orleans, UMR CNRS 7311, 45067 Orleans, France.
Franck SuzenetInstitut de Chimie Organique et Analytique, Universite d'Orleans, UMR CNRS 7311, 45067 Orleans, France.
R Mark RichardsonBrain Modulation Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213.ORCID 0000-0003-2620-7387
Samuel M PoloyacSmall Molecule Biomarker Core, University of Pittsburgh, Pittsburgh, PA 15213.
Donna B StolzCenter for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA 15213.
Ralf JockersInserm, U1016, Institut Cochin, 75014 Paris, France.ORCID 0000-0002-4354-1750
Paula A Witt-EnderbyMylan School of Pharmacy, Duquesne University, Pittsburgh, PA 15282.
Diane L CarlisleNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213.
Jean-Pierre VilardagaLaboratory for G-Protein Coupled Receptor Biology, Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA 15261; friedlanderr@upmc.edu jpv@pitt.edu.ORCID 0000-0002-1217-1435
Robert M FriedlanderNeuroapoptosis Laboratory, Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA 15213; friedlanderr@upmc.edu jpv@pitt.edu.
University of Pittsburgh · USCentral South University · CNDélégation Paris 5 · FRUniversité d'Orléans · FRDuquesne University · USNeuroscience Institute · IT
Funding
MODULATION OF CASPASE PATHWAYS IN HUNTINGTON'S DISEASER01NS039324 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FRIEDLANDER, ROBERT M. · 2000 to 2014
$5.5MMelatonin biosynthesis in neuronal mitochondriaR01NS100743 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FRIEDLANDER, ROBERT M. · 2018 to 2022
$2.0MStructural and Functional Mechanisms of PTH-Receptor SignalingR01DK102495 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CALERO, GUILLERMO ALBERTO, GARDELLA, THOMAS J · 2014 to 2017
$2.0MSustained cAMP Signals Triggered by Internalized PTH Receptor: New Consequences fR01DK087688 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VILARDAGA, JEAN-PIERRE · 2010 to 2014
$1.6MFunctional Role of Micro RNAs in Huntington's Disease PathogenesisR01NS077748 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FRIEDLANDER, ROBERT M. · 2012 to 2015
$1.6MJEOL JEM-1011 TRANSMISSION ELECTRON MICROSCOPE: MUSCULAR DYSTROPHYS10RR019003 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WATKINS, SIMON C · 2004 to 2004
$337kRequest for Ultracryomicrotomy equipmentS10RR025488 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WATKINS, SIMON C · 2009 to 2009
$179kNCRR NIH HHS S10 RR019003NCRR NIH HHS S10 RR025488NIDDK NIH HHS R01 DK087688NIDDK NIH HHS R01 DK102495NINDS NIH HHS R01 NS039324NINDS NIH HHS R01 NS077748NINDS NIH HHS R01 NS100743
Abstract
G protein-coupled receptors (GPCRs) are classically characterized as cell-surface receptors transmitting extracellular signals into cells. Here we show that central components of a GPCR signaling system comprised of the melatonin type 1 receptor (MT
Indexed as
Signal TransductionAnimalsBrain InjuriesBrain IschemiaCytochromes cMaleMelatoninMiceMitochondriaReceptor, Melatonin, MT1Cytochromes cMelatoninReceptor, Melatonin, MT1G protein-coupled receptorischemiamelatoninmitochondrianeuroprotection
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.