ArticleProceedings of the National Academy of Sciences of the United States of America2017
Endodermal germ-layer formation through active actin-driven migration triggered by N-cadherin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 38 citations in OpenAlex.
- Notch coordinates self-organization of germ layers and axial polarity in sea anemone gastruloids.Nature communications · 2026Article
- Optogenetic WNT signaling drives germ layer self-organization in a human gastruloid model.bioRxiv : the preprint server for biology · 2026Article
- Coping with uncertainty: Challenges for robust pattern formation in dynamical tissues.Seminars in cell & developmental biology · 2025Review
- Hoxb genes determine the timing of cell ingression by regulating cell surface fluctuations during zebrafish gastrulation.Development (Cambridge, England) · 2025Article
- Nance-Horan-syndrome-like 1b controls mesodermal cell migration by regulating protrusion and actin dynamics during zebrafish gastrulation.Communications biology · 2025Article
- StemSC: a cross-dataset human stemness index for single-cell samples.Stem cell research & therapy · 2022Article
- Review
- The mevalonate pathway is a crucial regulator of tendon cell specification.Development (Cambridge, England) · 2020Article
- Cadherin-11 Is Required for Neural Crest Specification and Survival.Frontiers in physiology · 2020Article
- Continuous Dynamic Modeling of Regulated Cell Adhesion: Sorting, Intercalation, and Involution.Biophysical journal · 2019Article
- Maternally regulated gastrulation as a source of variation contributing to cavefish forebrain evolution.eLife · 2019Article
- The endoderm: a divergent cell lineage with many commonalities.Development (Cambridge, England) · 2019Review
- In vivo topology converts competition for cell-matrix adhesion into directional migration.Nature communications · 2019Article
- Nodal signaling has dual roles in fate specification and directed migration during germ layer segregation in zebrafish.Development (Cambridge, England) · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Germ-layer formation during gastrulation is both a fundamental step of development and a paradigm for tissue formation and remodeling. However, the cellular and molecular basis of germ-layer segregation is poorly understood, mostly because of the lack of direct in vivo observations. We used mosaic zebrafish embryos to investigate the formation of the endoderm. High-resolution live imaging and functional analyses revealed that endodermal cells reach their characteristic innermost position through an active, oriented, and actin-based migration dependent on Rac1, which contrasts with the previously proposed differential adhesion cell sorting. Rather than being attracted to their destination, the yolk syncytial layer, cells appear to migrate away from their neighbors. This migration depends on N-cadherin that, when imposed in ectodermal cells, is sufficient to trigger their internalization without affecting their fate. Overall, these results lead to a model of germ-layer formation in which, upon N-cadherin expression, endodermal cells actively migrate away from their epiblastic neighbors to reach their internal position, revealing cell-contact avoidance as an unexplored mechanism driving germ-layer formation.
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