ArticleProceedings of the National Academy of Sciences of the United States of America2017
Combined circulating tumor DNA and protein biomarker-based liquid biopsy for the earlier detection of pancreatic cancers.
3 registry-linked trialsOpen access · bronzeAbstract readEvaluation Study
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 325 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
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325citing papers in PubMed, 2 pooled it
20.0field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Gastric Cancer Detection by Liquid Biopsy in Peripheral Blood: A Prospective Study
Pancreatic Cancer Detection by Liquid Biopsy in Peripheral Blood: A Prospective Study
Pancreatic Cancer Detection by Liquid Biopsy in Peripheral Blood: A Prospective Study
Who cites it
325 citing papers in PubMed, 2 syntheses or guidelines pooled it, 562 citations in OpenAlex.
- From radiomics to transformers in pancreatic cancer detection and prognosis.Frontiers in medicine · 2025Pooled it
- The role of novel biomarkers in the early diagnosis of pancreatic cancer: A systematic review and meta-analysis.PloS one · 2025Pooled it
- A multi-analyte blood test for acute spinal cord injury.The Journal of clinical investigation · 2025Trial
- Lead-Time Trajectory of CA19-9 as an Anchor Marker for Pancreatic Cancer Early Detection.Gastroenterology · 2021Trial
- Pancreatic Cancer Early Detection Biomarkers for High-Risk Individuals: Insights From the PRECEDE Consortium.International journal of cancer · 2026Review
- Review
- Carbohydrates metabolic reprogramming and tumor microenvironment in pancreatic cancer: targeting pathways.Molecular biology reports · 2026Review
- A bibliometric analysis of research trends and future directions in early detection of pancreatic cancer.Discover oncology · 2026Article
- Evidence Mapping of ctDNA Reporting in Pancreatic Ductal Adenocarcinoma: Toward a Shared Quantitative Language for ctDNA.Cancers · 2026Review
- Circulating Tumor DNA as a Biomarker in Pancreatic Cancer: Clinical Applications and Challenges.Clinical and translational gastroenterology · 2026Review
- Pilot study of screening method for pancreatic cancer using lipidomic profiling of plasma or serum.Communications medicine · 2026Article
- Profiling the pancreatic cancer secretome with metabolic glycoengineering.The Journal of biological chemistry · 2026Article
- Toward Timely Diagnosis of Pancreatic Cancer: Revolutionizing Early Detection Through Genomics, Artificial Intelligence, and Noninvasive Biomarkers.Journal of gastroenterology and hepatology · 2026Review
- Circulating tumor DNA-guided early detection and minimal residual disease monitoring in pancreatic and biliary cancers: evidence, barriers, and opportunities.World journal of surgical oncology · 2026Review
- Exploration of multi-omics liquid biopsy approaches for multi-cancer early detection: The PROMISE study.Innovation (Cambridge (Mass.)) · 2026Article
- Role of cancer-associated fibroblast-derived exosomes in pancreatic cancer: clinical therapeutic potential and targeting challenges.Frontiers in immunology · 2026Review
- Clinical Utility of Circulating Tumor DNA Analysis in Pancreatic Ductal Adenocarcinoma.Clinical Medicine Insights. Oncology · 2026Article
- Challenges of early detection of pancreatic cancer.The Journal of clinical investigation · 2025Review
- Development and validation of predictive models combining cell-Free DNA motifs and protein biomarkers for early detection of esophageal squamous cell carcinoma and precancerous lesion.Biomarker research · 2025Article
- Development of a serum protein biomarker panel for the diagnosis of pancreatic ductal adenocarcinoma using a machine learning approach.Scientific reports · 2025Article
265 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
40 authors at 15 institutions in 4 countries.
Joshua D CohenThe Ludwig Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Ammar A JavedDepartment of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Christopher ThoburnSidney Kimmel Cancer Center at Johns Hopkins, The Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Fay WongThe Ludwig Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Jeanne TieDivision of Systems Biology and Personalized Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3021, Australia.
Peter GibbsDivision of Systems Biology and Personalized Medicine, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3021, Australia.
C Max SchmidtDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202.
Michele T Yip-SchneiderDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202.
Peter J AllenDepartment of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY 10065.
Mark SchattnerDepartment of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065.
Randall E BrandDepartment of Medicine, University of Pittsburgh, Pittsburgh, PA 15260.
Aatur D SinghiDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA 15260.
Gloria M PetersenDepartment of Epidemiology, Mayo Clinic, Rochester, MN 55902.
Seung-Mo HongDepartment of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Song Cheol KimDepartment of Hepatobiliary and Pancreas Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.
Massimo FalconiDivision of Pancreatic Surgery, Department of Surgery, San Raffaele Scientific Institute Research Hospital, 20132 Milan, Italy.
Claudio DoglioniDepartment of Pathology, San Raffaele Scientific Institute Research Hospital, 20132 Milan, Italy.
Matthew J WeissDepartment of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Nita AhujaDepartment of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Jin HeDepartment of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Martin A MakaryDepartment of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Anirban MaitraThe Sheikh Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Samir M HanashThe Sheikh Ahmed Center for Pancreatic Cancer Research, The University of Texas MD Anderson Cancer Center, Houston, TX 77030.
Marco Dal MolinThe Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Yuxuan WangThe Ludwig Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Lu LiDepartment of Biostatistics, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205.
Janine PtakThe Ludwig Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Lisa DobbynThe Ludwig Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Joy SchaeferThe Ludwig Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Natalie SillimanThe Ludwig Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Maria PopoliThe Ludwig Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Michael G GogginsSidney Kimmel Cancer Center at Johns Hopkins, The Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Ralph H HrubanSidney Kimmel Cancer Center at Johns Hopkins, The Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Christopher L WolfgangDepartment of Surgery, The Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Alison P KleinSidney Kimmel Cancer Center at Johns Hopkins, The Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Cristian TomasettiSidney Kimmel Cancer Center at Johns Hopkins, The Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Nickolas PapadopoulosThe Ludwig Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Kenneth W KinzlerThe Ludwig Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21287.
Bert VogelsteinThe Ludwig Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21287; bertvog@gmail.com amlennon@jhmi.edu.
Anne Marie LennonThe Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21287; bertvog@gmail.com amlennon@jhmi.edu.
Johns Hopkins University · USSidney Kimmel Cancer Center · USCancer Research Center · USHoward Hughes Medical Institute · USIndiana University – Purdue University Indianapolis · USMemorial Sloan Kettering Cancer Center · USSan Raffaele University of Rome · ITSidney Kimmel Comprehensive Cancer Center · USThe University of Texas MD Anderson Cancer Center · USUniversity of Pittsburgh · USAsan Medical Center · KRMayo Clinic in Florida · USUniversity of Melbourne · AUUniversity of Ulsan · KRWestern Health · AU
Funding
Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6MTumor Antigens for Individual Signatures and TherapyP50CA062924 · NCI · JOHNS HOPKINS UNIVERSITY · PI LENNON, ANNE MARIE · 1993 to 2022
$54.6MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007309 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI COX, ANDREA L · 1985 to 2019
$43.2MTissue CoreP50CA102701 · NCI · MAYO CLINIC ROCHESTER · PI PETERSEN, GLORIA M. · 2004 to 2018
$32.7MClinical Validation Center for Early Detection of Pancreatic CancerU01CA200468 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI ANIRBAN MAITRA · 2016 to 2026
$11.0MRefinement and Discovery of Nuclear Matrix Protein Markers for Colorectal CancerU01CA152753 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KINZLER, KENNETH W., SCHOEN, ROBERT E. · 2010 to 2021
$6.8MImaging and Molecular Correlates of Progression in Cystic Neoplasms of the PancreasU01CA196403 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MAITRA, ANIRBAN · 2015 to 2020
$5.8MHoward Hughes Medical InstituteNCI NIH HHS P30 CA006973NCI NIH HHS P50 CA062924NCI NIH HHS P50 CA102701NCI NIH HHS U01 CA152753NCI NIH HHS U01 CA196403NCI NIH HHS U01 CA200468NIGMS NIH HHS T32 GM007309
Abstract
The earlier diagnosis of cancer is one of the keys to reducing cancer deaths in the future. Here we describe our efforts to develop a noninvasive blood test for the detection of pancreatic ductal adenocarcinoma. We combined blood tests for
Indexed as
AgedCA-19-9 AntigenCarcinoma, Pancreatic DuctalCase-Control StudiesCirculating Tumor DNAFemaleGenes, p53HumansLiquid BiopsyMaleMiddle AgedPancreatic NeoplasmsProto-Oncogene Proteins p21(ras)CA-19-9 AntigenCirculating Tumor DNAKRAS protein, humanProto-Oncogene Proteins p21(ras)circulating tumor DNAearly cancer detectionliquid biopsypancreatic cancerprotein biomarkers
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.