ArticleProceedings of the National Academy of Sciences of the United States of America2017
Treg-specific IL-27Rα deletion uncovers a key role for IL-27 in Treg function to control autoimmunity.
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In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
What it found
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The trial behind it
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Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Potential drug targets for chronic obstructive pulmonary disease in the plasma proteome identified through Mendelian randomization.BMC pulmonary medicine · 2025Pooled it
- Cytokines Associated with Activation of CD4International journal of molecular sciences · 2026Review
- Regulatory T cells in cardiac allograft vasculopathy: from mechanistic insights to clinical tolerance.Frontiers in immunology · 2026Review
- IL-27 promotes Treg cell expression of CD122 and fitness at homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- IL-27 limits HSPC differentiation during infection and protects from stem cell exhaustion.eLife · 2025Article
- Ligand-receptor interactions induce and mediate regulatory functions of BATF3Science advances · 2025Article
- Targeting Impaired Type I Interferon-IL-27 Signaling Rescues T Regulatory Cell Suppressive Function in Relapsing-Remitting Multiple Sclerosis.bioRxiv : the preprint server for biology · 2025Article
- Exploring the Role of Inflammation and Metabolites in Bell's Palsy and Potential Treatment Strategies.Biomedicines · 2025Article
- Myeloid activation clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer.The Journal of experimental medicine · 2024Article
- Deciphering Regulatory T-Cell Dynamics in Cancer Immunotherapy: Mechanisms, Implications, and Therapeutic Innovations.ACS pharmacology & translational science · 2024Review
- Role of IL-27 in COVID-19: A Thin Line between Protection and Disease Promotion.International journal of molecular sciences · 2024Review
- Intraperitoneal activation of myeloid cells clears ascites and reveals IL27-dependent regression of metastatic ovarian cancer.bioRxiv : the preprint server for biology · 2024Article
- Therapeutic induction of antigen-specific immune tolerance.Nature reviews. Immunology · 2024Review
- Immune microniches shape intestinal TNature · 2024Article
- Article
- Interleukin 27, like interferons, activates JAK-STAT signaling and promotes pro-inflammatory and antiviral states that interfere with dengue and chikungunya viruses replication in human macrophages.Frontiers in immunology · 2024Article
- An updated advancement of bifunctional IL-27 in inflammatory autoimmune diseases.Frontiers in immunology · 2024Review
- Commensal bacteria promote type I interferon signaling to maintain immune tolerance in mice.The Journal of experimental medicine · 2024Article
- Hedgehog Signaling Regulates Treg to Th17 Conversion Through Metabolic Rewiring in Breast Cancer.Cancer immunology research · 2023Article
- Cell type specific IL-27p28 (IL-30) deletion in mice uncovers an unexpected regulatory function of IL-30 in autoimmune inflammation.Scientific reports · 2023Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 1 country.
Jeongsu DoDepartment of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Dongkyun KimDepartment of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Sohee KimDepartment of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Alice Valentin-TorresDepartment of Neuroscience, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Nina DvorinaDepartment of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Eunjung JangDepartment of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Vivekananthan NagarajavelGenomic Medicine Institute, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Tara M DeSilvaDepartment of Neuroscience, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Xiaoxia LiDepartment of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Angela H TingGenomic Medicine Institute, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Dario A A VignaliDepartment of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261.
Stephen A StohlmanDepartment of Neuroscience, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
William M BaldwinDepartment of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195.
Booki MinDepartment of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195; minb@ccf.org.
Cleveland Clinic · USUPMC Hillman Cancer Center · US
Funding
Vascular Cell function and AtherosclerosisP01HL029582 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI FOX, PAUL L · 1985 to 2019
$32.0MSynergies among inhibitory receptors in tolerance, cancer & antiviral immunityP01AI108545 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI E. John Wherry · 2015 to 2026
$30.8MThe role of IL-27/Lag3 axis in regulating Foxp3+ regulatory T cell functionR01AI125247 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Booki Min · 2017 to 2026
$3.4MInterleukin-35 and the tumor microenvironmentR01CA203689 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VIGNALI, DARIO AA · 2016 to 2020
$1.9MPreclinical Study of IL-27-Conditioned Tregs to Treat GvHDR21AI121524 · NIAID · CLEVELAND CLINIC LERNER COM-CWRU · PI HAMILTON, BETTY K, MIN, BOOKI · 2016 to 2017
$436kNCI NIH HHS R01 CA203689NHLBI NIH HHS P01 HL029582NIAID NIH HHS P01 AI108545NIAID NIH HHS R01 AI125247NIAID NIH HHS R21 AI121524
Abstract
Dysregulated Foxp3
Indexed as
AnimalsAutoimmune DiseasesCentral Nervous SystemDrug Evaluation, PreclinicalEncephalomyelitisForkhead Transcription FactorsInterleukinsMice, TransgenicReceptors, CytokineReceptors, InterleukinT-Lymphocytes, RegulatoryForkhead Transcription FactorsFoxp3 protein, mouseIl27 protein, mouseIl27ra protein, mouseInterleukinsReceptors, CytokineReceptors, InterleukinautoimmunityFoxp3+ regulatory T cellsIL-27Tr1 cells
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Textmetadata
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Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.