Evidence map›Paper›PMID 28874473›Full record

ArticlemBio2017

Revitalization of a Forward Genetic Screen Identifies Three New Regulators of Fungal Secondary Metabolism in the Genus

Brandon T Pfannenstiel, Xixi Zhao, Jennifer Wortman, Philipp Wiemann, Kurt Throckmorton, Joseph E Spraker, Alexandra A Soukup, Xingyu Luo, Daniel L Lindner, Fang Yun Lim and 9 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 58 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Biosynthesis Regulation of Secondary Metabolite Production inJournal of fungi (Basel, Switzerland) · 2025
    Review
  6. Engineering of Global Transcriptional Regulators (GTRs) inJournal of fungi (Basel, Switzerland) · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Genetic Regulation of Mycotoxin Biosynthesis.Journal of fungi (Basel, Switzerland) · 2022
    Review
  14. Article
  15. Microorganisms · 2022
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Brandon T PfannenstielDepartment of Genetics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Xixi ZhaoDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Jennifer WortmanGenome Sequencing and Analysis Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Philipp WiemannDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-7983-2218
Kurt ThrockmortonDepartment of Genetics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Joseph E SprakerDepartment of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Alexandra A SoukupDepartment of Genetics, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0002-4149-2393
Xingyu LuoDepartment of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Daniel L LindnerCenter for Forest Mycology Research, Northern Research Station, U.S. Forest Service, Madison, Wisconsin, USA.
Fang Yun LimDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Benjamin P KnoxDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Brian HaasGenome Sequencing and Analysis Program, Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Gregory J FischerDepartment of Genetics, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Tsokyi ChoeraDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Robert A E ButchkoDepartment of Plant Pathology and Microbiology, Texas A&M University, College Station, Texas, USA.
Jin-Woo BokDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Katharyn J AffeldtDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Nancy P KellerDepartment of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA npkeller@wisc.edu jmpalmer@fs.fed.us.
Jonathan M PalmerCenter for Forest Mycology Research, Northern Research Station, U.S. Forest Service, Madison, Wisconsin, USA npkeller@wisc.edu jmpalmer@fs.fed.us.ORCID 0000-0003-0929-3658
University of Wisconsin–Madison · USBroad Institute · USUS Forest Service · USTexas A&M University · US

Funding

PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM007133 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PERNA, NICOLE T · 1985 to 2023
$16.5M
RESEARCH TRAINING IN HEMATOLOGYT32HL007899 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI Jane Ellen Churpek · 1998 to 2026
$8.2M
Molecular Genetic Mining of the Aspergillus Nidulans Secondary MetabolomeP01GM084077 · NIGMS · UNIVERSITY OF KANSAS LAWRENCE · PI OAKLEY, BERL RAY · 2008 to 2012
$5.4M
Comprehensive analysis of NRPS-derived metabolomes of three Aspergillus speciesR01GM112739 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI KELLER, NANCY P · 2015 to 2023
$2.8M
NHLBI NIH HHS T32 HL007899NIGMS NIH HHS P01 GM084077NIGMS NIH HHS R01 GM112739NIGMS NIH HHS T32 GM007133
6 · The paper itself

Abstract

The study of aflatoxin in

Indexed as

Gene Expression Regulation, FungalAspergillus nidulansCosmidsDNA, FungalFungal ProteinsGenes, FungalGenetic Complementation TestGenome, FungalHigh-Throughput Nucleotide SequencingMutationSecondary MetabolismSterigmatocystinDNA, FungalFungal ProteinsSterigmatocystinAspergillus nidulansforward geneticssecondary metabolismwhole-genome sequencing

Identifiers

PMID28874473
PMCPMC5587912
OpenAlexW2752199888

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.