Evidence map›Paper›PMID 28874466›Full record

ArticlemBio2017

An Alternative STAT Signaling Pathway Acts in Viral Immunity in

Mélanie Tanguy, Louise Véron, Przemyslaw Stempor, Julie Ahringer, Peter Sarkies, Eric A Miska

Open access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 57 citations in OpenAlex.

  1. Article
  2. Viral infection drives cell-intrinsic re-localization of thebioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Frontiers in tuberculosis · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. MultiplebioRxiv : the preprint server for biology · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Mélanie TanguyWellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, United Kingdom.
Louise VéronWellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, United Kingdom.
Przemyslaw StemporWellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, United Kingdom.
Julie AhringerWellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, United Kingdom.
Peter SarkiesMRC London Institute of Medical Sciences, London, United Kingdom p.sarkies@lms.mrc.ac.uk eam29@cam.ac.uk.
Eric A MiskaWellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge, Cambridge, United Kingdom p.sarkies@lms.mrc.ac.uk eam29@cam.ac.uk.
Wellcome/Cancer Research UK Gurdon Institute · GBWellcome Trust · GBMRC London Institute of Medical Sciences · GB

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Cancer Research UK 18583Cancer Research UK C13474/A18583Medical Research Council MC-A652-5PZ80NIH HHS P40 OD010440Wellcome TrustWellcome Trust 101863Wellcome Trust 104640/Z/14/Z
6 · The paper itself

Abstract

Across metazoans, innate immunity is vital in defending organisms against viral infection. In mammals, antiviral innate immunity is orchestrated by interferon signaling, activating the STAT transcription factors downstream of the JAK kinases to induce expression of antiviral effector genes. In the nematode

Indexed as

Immunity, InnateSignal TransductionAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsGene Expression ProfilingMutationNodaviridaeProtein-Tyrosine KinasesRNA InterferenceTrans-ActivatorsCaenorhabditis elegans ProteinsProtein-Tyrosine KinasesSID-3 protein, C elegansSTA-1 protein, C elegansTrans-ActivatorsCaenorhabditis elegansinnate immunityOrsay virusRNA virusSTAT signaling

Identifiers

PMID28874466
PMCPMC5587905
OpenAlexW2953020676

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.