ArticleHypertension (Dallas, Tex. : 1979)2017
Selective Deletion of Renin-b in the Brain Alters Drinking and Metabolism.
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Article in Hypertension (Dallas, Tex. : 1979), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
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Who cites it
13 citing papers in PubMed.
- The choroid plexus is a source of active renin in the central nervous system.Research square · 2026Article
- Neural Circuits Underlying Reciprocal Cardiometabolic Crosstalk: 2023 Arthur C. Corcoran Memorial Lecture.Hypertension (Dallas, Tex. : 1979) · 2024Article
- The hypothalamus as a key regulator of glucose homeostasis: emerging roles of the brain renin-angiotensin system.American journal of physiology. Cell physiology · 2023Review
- Renin-a in the Subfornical Organ Plays a Critical Role in the Maintenance of Salt-Sensitive Hypertension.Biomolecules · 2022Article
- Melanocortin MCPhysiological genomics · 2022Article
- Studies of salt and stress sensitivity on arterial pressure in renin-b deficient mice.PloS one · 2021Article
- Increased Susceptibility of Mice Lacking Renin-b to Angiotensin II-Induced Organ Damage.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Role of brain renin angiotensin system in neurodegeneration: An update.Saudi journal of biological sciences · 2020Review
- Brain Renin-Angiotensin System at the Intersect of Physical and Cognitive Frailty.Frontiers in neuroscience · 2020Review
- Liver-derived FGF21 is essential for full adaptation to ketogenic diet but does not regulate glucose homeostasis.Endocrine · 2020Article
- Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology.Physiological reviews · 2018Review
- Integrative Physiological Aspects of Brain RAS in Hypertension.Current hypertension reports · 2018Review
- Potential mechanisms of hypothalamic renin-angiotensin system activation by leptin and DOCA-salt for the control of resting metabolism.Physiological genomics · 2017Review
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Authors and funding
13 authors.
Keisuke ShinoharaFrom the Departments of Pharmacology (K.S., P.N., J.G., D.A.M., N.K.L., M.D.F., B.J.W., X.L., K.R., J.L.G., C.D.S.), Radiology (S.A.W., L.L.P.), and UIHC Center for Hypertension Research, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City (K.R., J.L.G., C.D.S.).
Pablo NakagawaFrom the Departments of Pharmacology (K.S., P.N., J.G., D.A.M., N.K.L., M.D.F., B.J.W., X.L., K.R., J.L.G., C.D.S.), Radiology (S.A.W., L.L.P.), and UIHC Center for Hypertension Research, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City (K.R., J.L.G., C.D.S.).
Javier GomezFrom the Departments of Pharmacology (K.S., P.N., J.G., D.A.M., N.K.L., M.D.F., B.J.W., X.L., K.R., J.L.G., C.D.S.), Radiology (S.A.W., L.L.P.), and UIHC Center for Hypertension Research, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City (K.R., J.L.G., C.D.S.).
Donald A MorganFrom the Departments of Pharmacology (K.S., P.N., J.G., D.A.M., N.K.L., M.D.F., B.J.W., X.L., K.R., J.L.G., C.D.S.), Radiology (S.A.W., L.L.P.), and UIHC Center for Hypertension Research, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City (K.R., J.L.G., C.D.S.).
Nicole K LittlejohnFrom the Departments of Pharmacology (K.S., P.N., J.G., D.A.M., N.K.L., M.D.F., B.J.W., X.L., K.R., J.L.G., C.D.S.), Radiology (S.A.W., L.L.P.), and UIHC Center for Hypertension Research, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City (K.R., J.L.G., C.D.S.).
Matthew D FolchertFrom the Departments of Pharmacology (K.S., P.N., J.G., D.A.M., N.K.L., M.D.F., B.J.W., X.L., K.R., J.L.G., C.D.S.), Radiology (S.A.W., L.L.P.), and UIHC Center for Hypertension Research, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City (K.R., J.L.G., C.D.S.).
Benjamin J WeidemannFrom the Departments of Pharmacology (K.S., P.N., J.G., D.A.M., N.K.L., M.D.F., B.J.W., X.L., K.R., J.L.G., C.D.S.), Radiology (S.A.W., L.L.P.), and UIHC Center for Hypertension Research, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City (K.R., J.L.G., C.D.S.).
Xuebo LiuFrom the Departments of Pharmacology (K.S., P.N., J.G., D.A.M., N.K.L., M.D.F., B.J.W., X.L., K.R., J.L.G., C.D.S.), Radiology (S.A.W., L.L.P.), and UIHC Center for Hypertension Research, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City (K.R., J.L.G., C.D.S.).
Susan A WalshFrom the Departments of Pharmacology (K.S., P.N., J.G., D.A.M., N.K.L., M.D.F., B.J.W., X.L., K.R., J.L.G., C.D.S.), Radiology (S.A.W., L.L.P.), and UIHC Center for Hypertension Research, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City (K.R., J.L.G., C.D.S.).
Laura L PontoFrom the Departments of Pharmacology (K.S., P.N., J.G., D.A.M., N.K.L., M.D.F., B.J.W., X.L., K.R., J.L.G., C.D.S.), Radiology (S.A.W., L.L.P.), and UIHC Center for Hypertension Research, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City (K.R., J.L.G., C.D.S.).
Kamal RahmouniFrom the Departments of Pharmacology (K.S., P.N., J.G., D.A.M., N.K.L., M.D.F., B.J.W., X.L., K.R., J.L.G., C.D.S.), Radiology (S.A.W., L.L.P.), and UIHC Center for Hypertension Research, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City (K.R., J.L.G., C.D.S.).
Justin L GrobeFrom the Departments of Pharmacology (K.S., P.N., J.G., D.A.M., N.K.L., M.D.F., B.J.W., X.L., K.R., J.L.G., C.D.S.), Radiology (S.A.W., L.L.P.), and UIHC Center for Hypertension Research, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City (K.R., J.L.G., C.D.S.).
Curt D SigmundFrom the Departments of Pharmacology (K.S., P.N., J.G., D.A.M., N.K.L., M.D.F., B.J.W., X.L., K.R., J.L.G., C.D.S.), Radiology (S.A.W., L.L.P.), and UIHC Center for Hypertension Research, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City (K.R., J.L.G., C.D.S.). curt-sigmund@uiowa.edu.
Funding
Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Jon C.D. Houtman · 2000 to 2026
$70.0MRole of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI GROBE, JUSTIN L · 2007 to 2022
$30.2MInteraction between leptin and angiotensin in the pathogenesis of obesity-hypertensionR01HL134850 · NHLBI · UNIVERSITY OF IOWA · PI Justin L Grobe · 2017 to 2026
$4.4MSHORT-TERM TRAINING: STUDENTS IN HEALTH PROF. SCHOOLST35HL007485 · NHLBI · UNIVERSITY OF IOWA · PI ROGHAIR, ROBERT D · 1985 to 2019
$4.3MRole of PPARG the PPARG Target Gene RBP7 in the EndotheliumR01HL131689 · NHLBI · UNIVERSITY OF IOWA · PI SIGMUND, CURT DANIEL · 2016 to 2018
$1.9MHypertension: Role of Smooth Muscle Cullin-3 and the CRL3 ComplexR01HL125603 · NHLBI · UNIVERSITY OF IOWA · PI SIGMUND, CURT DANIEL · 2015 to 2018
$1.7MInveon Preclinical PET, CT, and SPECT scanning systemS10RR025036 · NCRR · UNIVERSITY OF IOWA · PI HICHWA, RICHARD D · 2009 to 2009
$1.5MCentral Renin-Angiotensin System: Metabolism, Fluid Balance, and HypertensionR00HL098276 · NHLBI · UNIVERSITY OF IOWA · PI GROBE, JUSTIN L · 2012 to 2014
$715kCentral Renin-Angiotensin System: Metabolism, Fluid Balance, and HypertensionK99HL098276 · NHLBI · UNIVERSITY OF IOWA · PI GROBE, JUSTIN L · 2010 to 2011
$214kNCI NIH HHS P30 CA086862NCRR NIH HHS S10 RR025036NHLBI NIH HHS K99 HL098276NHLBI NIH HHS P01 HL084207NHLBI NIH HHS R00 HL098276NHLBI NIH HHS R01 HL125603NHLBI NIH HHS R01 HL131689NHLBI NIH HHS R01 HL134850NHLBI NIH HHS T35 HL007485
Abstract
The brain-specific isoform of renin (Ren-b) has been proposed as a negative regulator of the brain renin-angiotensin system (RAS). We analyzed mice with a selective deletion of Ren-b which preserved expression of the classical renin (Ren-a) isoform. We reported that Ren-b
Indexed as
AnimalsBasal MetabolismBrainDrinkingEnergy MetabolismHypertensionMiceProtein IsoformsReninRenin-Angiotensin SystemSympathetic Nervous SystemProtein IsoformsReninangiotensin IIbrainhypertensionreninsympathetic nervous system
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.