ArticleAntimicrobial agents and chemotherapy2017
Structure and Dynamics of FosA-Mediated Fosfomycin Resistance in Klebsiella pneumoniae and Escherichia coli.
Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 44 citations in OpenAlex.
- Perspectives for pharmaceutical screening at XFEL sources using the example of Lassa virus endonuclease.Acta crystallographica. Section D, Structural biology · 2026Article
- Whole Genome Characterization of Klebsiella Strains in European Hedgehogs and Human Nosocomial Settings Identified Shared Sequence Types, Antimicrobial Resistance Genes and Plasmids.Zoonoses and public health · 2026Article
- Identification and characteristics of a novel fosfomycin glutathione transferase, FosA12, from an MDR clinical isolate ofAntimicrobial agents and chemotherapy · 2026Article
- Characteristics ofMicroorganisms · 2026Article
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- IncL plasmid-mediated dissemination of OXA-48 β-lactamase andJAC-antimicrobial resistance · 2026Article
- Room-temperature X-ray fragment screening with serial crystallography.Nature communications · 2025Article
- DeepSEA: an alignment-free explainable approach to annotate antimicrobial resistance proteins.BMC bioinformatics · 2025Article
- Antechodynamics and Antechokinetics: Dynamics and Kinetics of Antibiotic Resistance Biomolecules.Biomolecules · 2025Review
- First identification and whole-genome characterization of human-associated Enterobacter roggenkampii and Enterobacter sichuanensis carrying blaJournal of global antimicrobial resistance · 2025Article
- Identification of a novel chromosome-encoded fosfomycin resistance geneFrontiers in microbiology · 2025Article
- Plasmid-Mediated Colistin and Fosfomycin Resistance among Clinical Isolates of ESBL- and Carbapenemase-ProducingArchives of Razi Institute · 2024Article
- Article
- Structural Studies ofInternational journal of molecular sciences · 2023Article
- A novel approach for combining the metagenome, metaresistome, metareplicome and causal inference to determine the microbes and their antibiotic resistance gene repertoire that contribute to dysbiosis.Microbial genomics · 2022Article
- The role of adjuvants in overcoming antibacterial resistance due to enzymatic drug modification.RSC medicinal chemistry · 2022Review
- Complete Genome Sequence of Klebsiella quasipneumoniae subsp.Microbiology resource announcements · 2022Article
- Oral fosfomycin activity against Klebsiella pneumoniae in a dynamic bladder infection in vitro model.The Journal of antimicrobial chemotherapy · 2022Article
- Differences in Fosfomycin Resistance Mechanisms between Pseudomonas aeruginosa andAntimicrobial agents and chemotherapy · 2022Review
- Cross-Resistance and the Mechanisms of Cephalosporin-Resistant Bacteria in Urinary Tract Infections Isolated in Indonesia.Current microbiology · 2021Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
Fosfomycin exhibits broad-spectrum antibacterial activity and is being reevaluated for the treatment of extensively drug-resistant pathogens. Its activity in Gram-negative organisms, however, can be compromised by expression of FosA, a metal-dependent transferase that catalyzes the conjugation of glutathione to fosfomycin, rendering the antibiotic inactive. In this study, we solved the crystal structures of two of the most clinically relevant FosA enzymes: plasmid-encoded FosA3 from
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Registered trials
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