Evidence map›Paper›PMID 28874164›Full record

ArticleJournal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance2017

Radiation-free CMR diagnostic heart catheterization in children.

Kanishka Ratnayaka, Joshua P Kanter, Anthony Z Faranesh, Elena K Grant, Laura J Olivieri, Russell R Cross, Ileen F Cronin, Karin S Hamann, Adrienne E Campbell-Washburn, Kendall J O'Brien and 3 more

Registry-linked trialOpen access · goldAbstract readEvaluation StudyVideo-Audio Media
In one paragraph

Article in Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02739087 (Radiation-Free Heart Catheterization Using MRI), which is not on this map. Cited by 41 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02739087 naunknown statusnot on this map

Radiation-Free Heart Catheterization Using MRI

TypeinterventionalSponsorJoshua KanterRan2015 to 2024Enrolled50ConditionsAortic Coarctation, Cardiomyopathy, Atrial Septal Defect, Aortic StenosisArmsMRI guided cardiac catheterization, Magnetic resonance imaging
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Cardiac MRI at Low Field Strengths.Journal of magnetic resonance imaging : JMRI · 2024
    Review
  9. Article
  10. Review
  11. Article
  12. Interventional cardiovascular magnetic resonance: state-of-the-art.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023
    Review
  13. Review
  14. Improved catheter tracking during cardiovascular magnetic resonance-guided cardiac catheterization using overlay visualization.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2022
    Article
  15. Review
  16. Review
  17. Review
  18. Real-Time Magnetic Resonance Imaging.Journal of magnetic resonance imaging : JMRI · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Kanishka RatnayakaCardiovascular and Pulmonary Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Building 10, Room 2c713, MSC 1538, Bethesda, MD, 20892-1538, USA. kratnayaka@rchsd.org.
Joshua P KanterDivision of Cardiology, Children's National Medical Center, 111 Michigan Ave, NW, Washington, DC, 20010, USA.
Anthony Z FaraneshCardiovascular and Pulmonary Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Building 10, Room 2c713, MSC 1538, Bethesda, MD, 20892-1538, USA.
Elena K GrantCardiovascular and Pulmonary Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Building 10, Room 2c713, MSC 1538, Bethesda, MD, 20892-1538, USA.
Laura J OlivieriDivision of Cardiology, Children's National Medical Center, 111 Michigan Ave, NW, Washington, DC, 20010, USA.
Russell R CrossDivision of Cardiology, Children's National Medical Center, 111 Michigan Ave, NW, Washington, DC, 20010, USA.
Ileen F CroninDivision of Cardiology, Children's National Medical Center, 111 Michigan Ave, NW, Washington, DC, 20010, USA.
Karin S HamannDivision of Cardiology, Children's National Medical Center, 111 Michigan Ave, NW, Washington, DC, 20010, USA.
Adrienne E Campbell-WashburnCardiovascular and Pulmonary Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Building 10, Room 2c713, MSC 1538, Bethesda, MD, 20892-1538, USA.
Kendall J O'BrienCardiovascular and Pulmonary Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Building 10, Room 2c713, MSC 1538, Bethesda, MD, 20892-1538, USA.
Toby RogersCardiovascular and Pulmonary Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Building 10, Room 2c713, MSC 1538, Bethesda, MD, 20892-1538, USA.
Michael S HansenCardiovascular and Pulmonary Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Building 10, Room 2c713, MSC 1538, Bethesda, MD, 20892-1538, USA.
Robert J LedermanCardiovascular and Pulmonary Branch, Division of Intramural Research, National Heart Lung and Blood Institute, National Institutes of Health, Building 10, Room 2c713, MSC 1538, Bethesda, MD, 20892-1538, USA.
Children's National · USNational Heart Lung and Blood Institute · USNational Institutes of Health · US

Funding

Real-time MRI guided cardiovascular interventionZIAHL005062 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEDERMAN, ROBERT J · 2009 to 2025
$21.6M
Diagnostic and interventional cardiovascular catheterizationZIDHL006061 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEDERMAN, ROBERT J · 2010 to 2025
$18.2M
Therapies enabled-cardiovascular interventional MRIZ01HL005062 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI LEDERMAN, ROBERT J · 2003 to 2008
$6.0M
Innovative Technology for MRI Guided ProceduresZIAHL006213 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI CAMPBELL-WASHBURN, ADRIENNE · 2016 to 2025
$5.4M
Intramural NIH HHS Z01 HL005062NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001I
6 · The paper itself

Abstract

backgroundChildren with heart disease may require repeated X-Ray cardiac catheterization procedures, are more radiosensitive, and more likely to survive to experience oncologic risks of medical radiation. Cardiovascular magnetic resonance (CMR) is radiation-free and offers information about structure, function, and perfusion but not hemodynamics. We intend to perform complete radiation-free diagnostic right heart catheterization entirely using CMR fluoroscopy guidance in an unselected cohort of pediatric patients; we report the feasibility and safety.

methodsWe performed 50 CMR fluoroscopy guided comprehensive transfemoral right heart catheterizations in 39 pediatric (12.7 ± 4.7 years) subjects referred for clinically indicated cardiac catheterization. CMR guided catheterizations were assessed by completion (success/failure), procedure time, and safety events (catheterization, anesthesia). Pre and post CMR body temperature was recorded. Concurrent invasive hemodynamic and diagnostic CMR data were collected.

resultsDuring a twenty-two month period (3/2015 - 12/2016), enrolled subjects had the following clinical indications: post-heart transplant 33%, shunt 28%, pulmonary hypertension 18%, cardiomyopathy 15%, valvular heart disease 3%, and other 3%. Radiation-free CMR guided right heart catheterization attempts were all successful using passive catheters. In two subjects with septal defects, right and left heart catheterization were performed. There were no complications. One subject had six such procedures. Most subjects (51%) had undergone multiple (5.5 ± 5) previous X-Ray cardiac catheterizations. Retained thoracic surgical or transcatheter implants (36%) did not preclude successful CMR fluoroscopy heart catheterization. During the procedure, two subjects were receiving vasopressor infusions at baseline because of poor cardiac function, and in ten procedures, multiple hemodynamic conditions were tested.

conclusionsComprehensive CMR fluoroscopy guided right heart catheterization was feasible and safe in this small cohort of pediatric subjects. This includes subjects with previous metallic implants, those requiring continuous vasopressor medication infusions, and those requiring pharmacologic provocation. Children requiring multiple, serial X-Ray cardiac catheterizations may benefit most from radiation sparing. This is a step toward wholly CMR guided diagnostic (right and left heart) cardiac catheterization and future CMR guided cardiac intervention.

trial registrationClinicalTrials.gov NCT02739087 registered February 17, 2016.

Indexed as

Magnetic Resonance Imaging, InterventionalAdolescentAge FactorsCardiac CatheterizationChildFeasibility StudiesFemaleHeart DiseasesHemodynamicsHumansMalePredictive Value of TestsRadiation ExposureTime FactorsCatheterizationInterventional Cardiovascular MRIMagnetic Resonance ImagingMRI fluoroscopyReal-time MRI

Identifiers

PMID28874164
PMCPMC5585983
OpenAlexW2747347683

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.