Evidence map›Paper›PMID 28874118›Full record

ArticleBMC genomics2017

A miRNA catalogue and ncRNA annotation of the short-living fish Nothobranchius furzeri.

Mario Baumgart, Emanuel Barth, Aurora Savino, Marco Groth, Philipp Koch, Andreas Petzold, Ivan Arisi, Matthias Platzer, Manja Marz, Alessandro Cellerino

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in BMC genomics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Mario BaumgartLeibniz Institute for Age Research - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745, Jena, Germany.
Emanuel BarthLeibniz Institute for Age Research - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745, Jena, Germany.ORCID http://orcid.org/0000-0003-0803-8858
Aurora SavinoBabraham Institute, Cambridge, England.
Marco GrothLeibniz Institute for Age Research - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745, Jena, Germany.
Philipp KochLeibniz Institute for Age Research - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745, Jena, Germany.
Andreas PetzoldDresden University of Technology, Dresden, Germany.
Ivan ArisiEuropean Brain Research Institute (EBRI), Rome, Italy.
Matthias PlatzerLeibniz Institute for Age Research - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745, Jena, Germany.
Manja MarzLeibniz Institute for Age Research - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745, Jena, Germany. manja@uni-jena.de.
Alessandro CellerinoLeibniz Institute for Age Research - Fritz Lipmann Institute (FLI), Beutenbergstraße 11, 07745, Jena, Germany. alessandro.cellerino@sns.it.
Leibniz Institute on Aging - Fritz Lipmann Institute (FLI) · DEBabraham Institute · GBEuropean Brain Research Institute · ITScuola Normale Superiore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe short-lived fish Nothobranchius furzeri is the shortest-lived vertebrate that can be cultured in captivity and was recently established as a model organism for aging research. Small non-coding RNAs, especially miRNAs, are implicated in age dependent control of gene expression.

resultsHere, we present a comprehensive catalogue of miRNAs and several other non-coding RNA classes (ncRNAs) for Nothobranchius furzeri. Analyzing multiple small RNA-Seq libraries, we show most of these identified miRNAs are expressed in at least one of seven Nothobranchius species. Additionally, duplication and clustering of N. furzeri miRNAs was analyzed and compared to the four fish species Danio rerio, Oryzias latipes, Gasterosteus aculeatus and Takifugu rubripes. A peculiar characteristic of N. furzeri, as compared to other teleosts, was a duplication of the miR-29 cluster.

conclusionThe completeness of the catalogue we provide is comparable to that of the zebrafish. This catalogue represents a basis to investigate the role of miRNAs in aging and development in this species.

Indexed as

Gene LibraryAgingAnimalsCyprinodontiformesGene DuplicationLongevityMicroRNAsMolecular Sequence AnnotationRNA, UntranslatedMicroRNAsRNA, UntranslatedFish miRNA evolutionmiRNomencRNANothobranchius furzeri

Identifiers

PMID28874118
PMCPMC5584509
OpenAlexW2949110059

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.