ArticlePloS one2017
Molecular prediction of lytic vs lysogenic states for Microcystis phage: Metatranscriptomic evidence of lysogeny during large bloom events.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Impact of Climate Change on Cyanobacteria-Cyanophage Interactions and Their Role in Cyanobacterial Blooms in Freshwater Lakes.Global change biology · 2026Article
- Acclimation temperature influences phage susceptibility in a toxin-producing strain ofMicrobiology spectrum · 2026Article
- Lysogen formation governs colonies while lytic infection is more prevalent in single cells of the bloom-forming cyanobacterium,bioRxiv : the preprint server for biology · 2025Article
- Proliferative and viability effects of two cyanophages on freshwater bloom-forming species Microcystis aeruginosa and Raphidiopsis raciborskii vary between strains.Scientific reports · 2025Article
- Contrasting viral infection strategies for single cell and colonial Microcystis populations consistent with Black Queen dynamics.The ISME journal · 2025Article
- Lytic and temperate phage naturally coexist in a dynamic population model.The ISME journal · 2024Article
- Ecological Dynamics of Broad- and Narrow-Host-Range Viruses Infecting the Bloom-Forming Toxic Cyanobacterium Microcystis aeruginosa.Applied and environmental microbiology · 2023Article
- Climate change and the aquatic continuum: A cyanobacterial comeback story.Environmental microbiology reports · 2023Review
- Multi-year molecular quantification and 'omics analysis ofFrontiers in microbiology · 2023Article
- Viruses may facilitate the cyanobacterial blooming during summer bloom succession in Xiangxi Bay of Three Gorges Reservoir, China.Frontiers in microbiology · 2023Article
- The Life Cycle Transitions of Temperate Phages: Regulating Factors and Potential Ecological Implications.Viruses · 2022Review
- Changes in Microbiome Activity and Sporadic Viral Infection Help Explain Observed Variability in Microcosm Studies.Frontiers in microbiology · 2022Article
- A comparative study of metatranscriptomic assessment methods to characterize Microcystis blooms.Limnology and oceanography, methods · 2021Article
- Occurrence and diversity of viruses associated with cyanobacterial communities in a Brazilian freshwater reservoir.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Harmful Algal Blooms Threaten the Health of Peri-Urban Fisher Communities: A case study in Kisumu Bay, Lake Victoria, Kenya.Exposure and health · 2020Article
- Expanding the Diversity of Bacterioplankton Isolates and Modeling Isolation Efficacy with Large-Scale Dilution-to-Extinction Cultivation.Applied and environmental microbiology · 2020Article
- Tracing the active genetic diversity of Microcystis and Microcystis phage through a temporal survey of Taihu.PloS one · 2020Article
- The "Neglected Viruses" ofFrontiers in microbiology · 2020Article
- Cooccurrence of Broad- and Narrow-Host-Range Viruses Infecting the Bloom-Forming Toxic Cyanobacterium Microcystis aeruginosa.Applied and environmental microbiology · 2019Article
- Insight Into the Molecular Mechanisms for Microcystin Biodegradation in Lake Erie and Lake Taihu.Frontiers in microbiology · 2019Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microcystis aeruginosa is a freshwater bloom-forming cyanobacterium capable of producing the potent hepatotoxin, microcystin. Despite increased interest in this organism, little is known about the viruses that infect it and drive nutrient mobilization and transfer of genetic material between organisms. The genomic complement of sequenced phage suggests these viruses are capable of integrating into the host genome, though this activity has not been observed in the laboratory. While analyzing RNA-sequence data obtained from Microcystis blooms in Lake Tai (Taihu, China), we observed that a series of lysogeny-associated genes were highly expressed when genes involved in lytic infection were down-regulated. This pattern was consistent, though not always statistically significant, across multiple spatial and temporally distinct samples. For example, samples from Lake Tai (2014) showed a predominance of lytic virus activity from late July through October, while genes associated with lysogeny were strongly expressed in the early months (June-July) and toward the end of bloom season (October). Analyses of whole phage genome expression shows that transcription patterns are shared across sampling locations and that genes consistently clustered by co-expression into lytic and lysogenic groups. Expression of lytic-cycle associated genes was positively correlated to total dissolved nitrogen, ammonium concentration, and salinity. Lysogeny-associated gene expression was positively correlated with pH and total dissolved phosphorous. Our results suggest that lysogeny may be prevalent in Microcystis blooms and support the hypothesis that environmental conditions drive switching between temperate and lytic life cycles during bloom proliferation.
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