ArticlePloS one2017
Russian isolates enlarge the known geographic diversity of Francisella tularensis subsp. mediasiatica.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 61 citations in OpenAlex.
- Complete genome and plasmid sequence, and chemotaxonomic analysis of Francisella sp. strain W12-1067, now designated as Allofrancisella heilbronnii.BMC microbiology · 2025Article
- Detection of Francisellaceae and the differentiation of main European F. tularensis ssp. holarctica strains (Clades) by new designed qPCR assays.BMC microbiology · 2025Article
- Virulence and genome analysis of three historicalFrontiers in cellular and infection microbiology · 2025Article
- Development of a Real-Time PCR Assay for the Detection ofMicroorganisms · 2024Article
- Genetic Homogeneity ofPathogens (Basel, Switzerland) · 2024Article
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- Tularemia treatment: experimental and clinical data.Frontiers in microbiology · 2023Review
- Hazard potential of Swiss Ixodes ricinus ticks: Virome composition and presence of selected bacterial and protozoan pathogens.PloS one · 2023Article
- Phylogeography ofFrontiers in microbiology · 2023Article
- Rapid Detection of Lipopolysaccharide and Whole Cells ofMicromachines · 2022Article
- Genetic diversity of Francisella tularensis subsp. holarctica in Kazakhstan.PLoS neglected tropical diseases · 2021Article
- Reorganized Genomic Taxonomy ofMicroorganisms · 2021Article
- Genetic Traces of theMicroorganisms · 2020Article
- The Comparative Virulence ofMicroorganisms · 2020Article
- Draft Genome Sequence of the Strain Francisella tularensis subsp.Microbiology resource announcements · 2020Article
- Optimized MALDI TOF Mass Spectrometry Identification ofMicroorganisms · 2020Article
- Differentiation of Francisella tularensis Subspecies and Subtypes.Journal of clinical microbiology · 2020Article
- Draft Genome Sequences of Three Francisella tularensis subsp.Microbiology resource announcements · 2020Article
- Ecology ofAnnual review of entomology · 2020Review
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Francisella tularensis, a small Gram-negative bacterium, is capable of infecting a wide range of animals, including humans, and causes a plague-like disease called tularemia-a highly contagious disease with a high mortality rate. Because of these characteristics, F. tularensis is considered a potential agent of biological terrorism. Currently, F. tularensis is divided into four subspecies, which differ in their virulence and geographic distribution. Two of them, subsp. tularensis (primarily found in North America) and subsp. holarctica (widespread across the Northern Hemisphere), are responsible for tularemia in humans. Subsp. novicida is almost avirulent in humans. The fourth subspecies, subsp. mediasiatica, is the least studied because of its limited distribution and impact in human health. It is found only in sparsely populated regions of Central Asia. In this report, we describe the first focus of naturally circulating F. tularensis subsp. mediasiatica in Russia. We isolated and characterized 18 strains of this subspecies in the Altai region. All strains were highly virulent in mice. The virulence of subsp. mediasiatica in a vaccinated mouse model is intermediate between that of subsp. tularensis and subsp. holarctica. Based on a multiple-locus variable number tandem repeat analysis (MLVA), we show that the Altaic population of F. tularensis subsp. mediasiatica is genetically distinct from the classical Central Asian population, and probably is endemic to Southern Siberia. We propose to subdivide the mediasiatica subspecies into three phylogeographic groups, M.I, M.II and M.III.
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