Evidence map›Paper›PMID 28873373›Full record

ArticleNephron2018

Biomarkers of Renal Injury in Cirrhosis: Association with Acute Kidney Injury and Recovery after Liver Transplantation.

Ashwani K Singal, Bradford Jackson, Glauber B Pereira, Kirk B Russ, Paul Stephen Fitzmorris, Donny Kakati, Page Axley, Sujan Ravi, Toni Seay, Satish P Ramachandra Rao and 4 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nephron, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Management of Hepatorenal Syndrome: A Review.Journal of clinical and translational hepatology · 2020
    Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Ashwani K SingalDivision of Gastroenterology and Hepatology, Department of Medicine, University of Alabama, Birmingham, AL, USA.
Bradford Jackson
Glauber B Pereira
Kirk B Russ
Paul Stephen Fitzmorris
Donny Kakati
Page Axley
Sujan Ravi
Toni Seay
Satish P Ramachandra Rao
Ravindra Mehta
Yong-Fang Kuo
Karan P Singh
Anupam Agarwal
University of California, San Diego · USJPS Health Network · USThe University of Texas Health Science Center at San Antonio · USThe University of Texas Medical Branch at Galveston · USUniversity of Alabama · USUniversity of Alabama at Birmingham · US

Funding

UAB Center for Clinical and Translational Science (CCTS)UL1TR001417 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KIMBERLY, ROBERT P. · 2015 to 2018
$31.4M
UAB-UCSD O'Brien Core Center for Acute Kidney Injury ResearchP30DK079337 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGARWAL, ANUPAM · 2008 to 2022
$18.3M
NCATS NIH HHS UL1 TR001417NIDDK NIH HHS P30 DK079337
6 · The paper itself

Abstract

backgroundTo define urine or serum biomarkers in predicting renal function recovery after liver transplantation (LT).

methodsAdults listed for LT (February 2011-July 2014) and with modified diet for renal disease-6 (MDRD-6) <60 mL/min provided urine/blood samples at baseline and serially until LT for biomarkers in serum (pg/mL) and urine (pg/mg creatinine).

resultsOf 271 LT listed patients (mean age 57 years, 63% males, median listing MELD 17.5), 1 year acute kidney injury (AKI) probability was 49%, with odds of 1.3-, 3.0-, 4.6-, and 8.5-fold times for listing MELD 16-20, 21-25, 26-30, and >30, compared to MELD <16. Thirty-seven people died over 1 year from the time of listing, with twofold increased odds with AKI. Among 67 patients with MDRD <60, only urinary epidermal growth factor was different comparing AKI (increase in serum creatinine ≥0.3 mg/dL from baseline within past 3 months) vs. no AKI (2,254 vs. 4,253, p = 0.003). Differences between acute tubular necrosis (ATN) and hepatorenal syndrome could not be ascertained for a small sample of 3 patients with ATN. Analyzing 15 of 43 receiving LT and MDRD-6 <30 prior to LT, biomarkers were not different comparing 5 patients recovering renal function (MDRD-6 >50 mL/min) at 6 months vs. 10 without recovery.

conclusionsAKI is common among LT listed patients, with a negative impact on transplant-free survival. Serum and urine biomarkers are not associated with the recovery of renal function after LT. Multicenter studies are suggested to (a) develop strategies to reduce the development of AKI and (b) derive novel biomarkers for use in accurately predicting renal recovery after LT.

Indexed as

Liver TransplantationAcute Kidney InjuryAdultAgedBiomarkersCohort StudiesDietEpidermal Growth FactorFemaleHumansKidney Function TestsKidney TubulesLiver CirrhosisMaleMiddle AgedNecrosisBiomarkersEpidermal Growth FactorAcute kidney injuryBiomarkersCirrhosisEnd-stage renal diseaseSimultaneous liver kidney

Identifiers

PMID28873373
PMCPMC5828970
OpenAlexW2751712824

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.