ReviewInvestigative ophthalmology & visual science2017
Photoreceptor-Based Biomarkers in AOSLO Retinal Imaging.
Review in Investigative ophthalmology & visual science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 61 citations in OpenAlex.
- Use of a Retinal Phantom to Facilitate Adaptive Optics Scanning Light Ophthalmoscopy Imaging in a Multicenter Clinical Trial.Translational vision science & technology · 2026Trial
- In Vivo Human Cone Photoreceptor Inner Segment Diameter Database Using Adaptive Optics Retinal Imaging.Investigative ophthalmology & visual science · 2026Article
- Cone Contrast and Entropy of Adaptive Optics Images in Choroideremia.Current eye research · 2026Article
- Selected Aspects of Optical Coherence Tomography and Adaptive Optics in Patients with Increased Body Mass Index.Biomedicines · 2026Article
- Retinal structure and function recovery over five years in Vogt-Koyanagi-Harada disease using adaptive optics and microperimetry.Scientific reports · 2026Article
- Structural analysis of cone photoreceptors in AO-OCT enables S-cone identification by a support vector machine classifier.Biomedical optics express · 2026Article
- Dynamics of color vision recovery in Vogt-Koyanagi-Harada disease: a longitudinal study using cone contrast test and adaptive optics imaging.Journal of ophthalmic inflammation and infection · 2025Article
- 3D-printed phantoms for measuring lateral resolution and contrast performance of ophthalmic adaptive optics imaging systems.Biomedical optics express · 2025Article
- Enhanced genotype-phenotype analysis using multimodal adaptive optics and 3D protein structure in Bietti Crystalline Dystrophy.American journal of ophthalmology case reports · 2025Article
- Review
- Acute retinal pigment epitheliitis using adaptive optics imaging: a case report.BMC ophthalmology · 2024Article
- Optimization-Based Pairwise Interaction Point Process (O-PIPP): A Precise and Universal Retinal Mosaic Modeling Approach.Investigative ophthalmology & visual science · 2024Article
- Intervisit Reproducibility of Foveal Cone Density Metrics.Translational vision science & technology · 2024Article
- The effect of sampling window size on topographical maps of foveal cone density.Frontiers in ophthalmology · 2024Article
- Clinical Application of Adaptive Optics Imaging in Diagnosis, Management, and Monitoring of Ophthalmological Diseases: A Narrative Review.Medical science monitor : international medical journal of experimental and clinical research · 2023Review
- Volume-accumulated reflectivity of the outer retina (integral) on spectral domain optical coherence tomography as a predictor of cone cell density: a pilot study.BMC ophthalmology · 2023Article
- Deep learning-enabled volumetric cone photoreceptor segmentation in adaptive optics optical coherence tomography images of normal and diseased eyes.Biomedical optics express · 2023Article
- Comprehensive automatic processing and analysis of adaptive optics flood illumination retinal images on healthy subjects.Biomedical optics express · 2023Article
- The Explanation of Photopic Luminous Efficiency Curve by Using Both of the Cones' Optical Fiber Coupling Effects and the Absorption of L Cones.Sensors (Basel, Switzerland) · 2023Article
- Extracting spacing-derived estimates of rod density in healthy retinae.Biomedical optics express · 2023Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Improved understanding of the mechanisms underlying inherited retinal degenerations has created the possibility of developing much needed treatments for these relentless, blinding diseases. However, standard clinical indicators of retinal health (such as visual acuity and visual field sensitivity) are insensitive measures of photoreceptor survival. In many retinal degenerations, significant photoreceptor loss must occur before measurable differences in visual function are observed. Thus, there is a recognized need for more sensitive outcome measures to assess therapeutic efficacy as numerous clinical trials are getting underway. Adaptive optics (AO) retinal imaging techniques correct for the monochromatic aberrations of the eye and can be used to provide nearly diffraction-limited images of the retina. Many groups routinely are using AO imaging tools to obtain in vivo images of the rod and cone photoreceptor mosaic, and it now is possible to monitor photoreceptor structure over time with single cell resolution. Highlighting recent work using AO scanning light ophthalmoscopy (AOSLO) across a range of patient populations, we review the development of photoreceptor-based metrics (e.g., density/geometry, reflectivity, and size) as candidate biomarkers. Going forward, there is a need for further development of automated tools and normative databases, with the latter facilitating the comparison of data sets across research groups and devices. Ongoing and future clinical trials for inherited retinal diseases will benefit from the improved resolution and sensitivity that multimodal AO retinal imaging affords to evaluate safety and efficacy of emerging therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.