ArticleRadiology2018
Gadolinium Chelate Safety in Pregnancy: Barely Detectable Gadolinium Levels in the Juvenile Nonhuman Primate after in Utero Exposure.
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Article in Radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27citing papers in PubMed
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Who cites it
27 citing papers in PubMed, 63 citations in OpenAlex.
- Trial
- The human placenta and its role in reproductive outcomes revisited.Physiological reviews · 2025Review
- Fetal Safety in MRI During Pregnancy: A Comprehensive Review.Diagnostics (Basel, Switzerland) · 2025Review
- Magnetic resonance imaging of placental intralobule structure and function in a preclinical nonhuman primate model†.Biology of reproduction · 2024Article
- CT angiography for characterization of advanced placenta accreta spectrum: indications, risks, and benefits.Abdominal radiology (New York) · 2024Review
- Giant ovarian yolk sac tumor during late pregnancy: a case report and literature review.Frontiers in oncology · 2024Article
- Advanced magnetic resonance imaging in human placenta: insights into fetal growth restriction and congenital heart disease.Frontiers in cardiovascular medicine · 2024Review
- Safety of Magnetic Resonance Imaging in Pregnancy.Radiologie (Heidelberg, Germany) · 2023Review
- Gadolinium during human pregnancy following administration of gadolinium chelate before pregnancy.Birth defects research · 2023Article
- Cervical cancer in the pregnant population.Abdominal radiology (New York) · 2023Review
- Utilizing Contrast-Enhanced Ultrasonography with Phosphatidylserine Microbubbles to Detect Placental Inflammation in Rhesus Macaques.Molecules (Basel, Switzerland) · 2023Article
- Impaired placental hemodynamics and function in a non-human primate model of gestational protein restriction.Scientific reports · 2023Article
- Ferumoxytol dynamic contrast enhanced magnetic resonance imaging identifies altered placental cotyledon perfusion in rhesus macaques†.Biology of reproduction · 2022Article
- How the Chemical Properties of GBCAs Influence Their Safety Profiles In Vivo.Molecules (Basel, Switzerland) · 2021Review
- MRI in Pregnancy and Precision Medicine: A Review from Literature.Journal of personalized medicine · 2021Review
- Adrenal hemorrhage and hemorrhagic masses; diagnostic workup and imaging findings.The British journal of radiology · 2021Review
- Cardiovascular magnetic resonance in women with cardiovascular disease: position statement from the Society for Cardiovascular Magnetic Resonance (SCMR).Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021Review
- Contrast-Enhanced Ultrasound for Assessing Abdominal Conditions in Pregnancy.Medicina (Kaunas, Lithuania) · 2020Article
- Detection and imaging of gadolinium accumulation in human bone tissue by micro- and submicro-XRF.Scientific reports · 2020Article
- Impact of ferumoxytol magnetic resonance imaging on the rhesus macaque maternal-fetal interface†.Biology of reproduction · 2020Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Joao Prola-NettoFrom the Departments of Radiology (J.P.N., K.Y.O.), Neurology (J.P.N.), and Obstetrics and Gynecology, Division of Maternal Fetal Medicine (A.E.F.), and Advanced Imaging Research Center (M.W.), Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Room L603, Portland, OR 97239; Divisions of Reproductive and Developmental Sciences (V.H.J.R., A.E.F.) and Neurosciences (E.L.S.), Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Ore; and Department of Chemistry, Portland State University, Portland, Ore (M.W., C.A.M.).
Mark WoodsFrom the Departments of Radiology (J.P.N., K.Y.O.), Neurology (J.P.N.), and Obstetrics and Gynecology, Division of Maternal Fetal Medicine (A.E.F.), and Advanced Imaging Research Center (M.W.), Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Room L603, Portland, OR 97239; Divisions of Reproductive and Developmental Sciences (V.H.J.R., A.E.F.) and Neurosciences (E.L.S.), Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Ore; and Department of Chemistry, Portland State University, Portland, Ore (M.W., C.A.M.).
Victoria H J RobertsFrom the Departments of Radiology (J.P.N., K.Y.O.), Neurology (J.P.N.), and Obstetrics and Gynecology, Division of Maternal Fetal Medicine (A.E.F.), and Advanced Imaging Research Center (M.W.), Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Room L603, Portland, OR 97239; Divisions of Reproductive and Developmental Sciences (V.H.J.R., A.E.F.) and Neurosciences (E.L.S.), Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Ore; and Department of Chemistry, Portland State University, Portland, Ore (M.W., C.A.M.).
Elinor L SullivanFrom the Departments of Radiology (J.P.N., K.Y.O.), Neurology (J.P.N.), and Obstetrics and Gynecology, Division of Maternal Fetal Medicine (A.E.F.), and Advanced Imaging Research Center (M.W.), Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Room L603, Portland, OR 97239; Divisions of Reproductive and Developmental Sciences (V.H.J.R., A.E.F.) and Neurosciences (E.L.S.), Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Ore; and Department of Chemistry, Portland State University, Portland, Ore (M.W., C.A.M.).
Christina Ann MillerFrom the Departments of Radiology (J.P.N., K.Y.O.), Neurology (J.P.N.), and Obstetrics and Gynecology, Division of Maternal Fetal Medicine (A.E.F.), and Advanced Imaging Research Center (M.W.), Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Room L603, Portland, OR 97239; Divisions of Reproductive and Developmental Sciences (V.H.J.R., A.E.F.) and Neurosciences (E.L.S.), Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Ore; and Department of Chemistry, Portland State University, Portland, Ore (M.W., C.A.M.).
Antonio E FriasFrom the Departments of Radiology (J.P.N., K.Y.O.), Neurology (J.P.N.), and Obstetrics and Gynecology, Division of Maternal Fetal Medicine (A.E.F.), and Advanced Imaging Research Center (M.W.), Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Room L603, Portland, OR 97239; Divisions of Reproductive and Developmental Sciences (V.H.J.R., A.E.F.) and Neurosciences (E.L.S.), Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Ore; and Department of Chemistry, Portland State University, Portland, Ore (M.W., C.A.M.).
Karen Y OhFrom the Departments of Radiology (J.P.N., K.Y.O.), Neurology (J.P.N.), and Obstetrics and Gynecology, Division of Maternal Fetal Medicine (A.E.F.), and Advanced Imaging Research Center (M.W.), Oregon Health and Science University, 3181 SW Sam Jackson Park Rd, Room L603, Portland, OR 97239; Divisions of Reproductive and Developmental Sciences (V.H.J.R., A.E.F.) and Neurosciences (E.L.S.), Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Ore; and Department of Chemistry, Portland State University, Portland, Ore (M.W., C.A.M.).
Oregon Health & Science University · USOregon National Primate Research Center · USAdvanced Imaging Research (United States) · USPortland State University · US
Funding
Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9MYR 50 PROJ- ROBERTS PRIMATE ISLETP51RR000163 · NCRR · OREGON REGIONAL PRIMATE RESEARCH CENTER · PI FRUH, KLAUS J · 1985 to 2011
$140.8MOregon Clinical and Translational Research InstituteUL1TR000128 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ELLISON, DAVID H · 2012 to 2015
$28.7MDevelopmental Exposure to Maternal Obesity-Induced Inflammation Impacts Offspring Brain and Negative Valence BehaviorsR01MH107508 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI SULLIVAN, ELINOR L. · 2015 to 2019
$3.8MDevelopment and validation of MR imaging methods for in vivo assessment of placental perfusion and oxygenationR01HD086331 · NICHD · OREGON HEALTH & SCIENCE UNIVERSITY · PI FRIAS, ANTONIO E · 2015 to 2019
$2.6MTranslational Training in Biomedical Imaging ResearchR25EB016671 · NIBIB · OREGON HEALTH & SCIENCE UNIVERSITY · PI COAKLEY, FERGUS V · 2013 to 2017
$613kICP-MS to Measure Elemental ConcentrationsS10RR025512 · NCRR · OREGON HEALTH & SCIENCE UNIVERSITY · PI RALLE, MARTINA · 2009 to 2009
$168kNCATS NIH HHS UL1 TR000128NCRR NIH HHS P51 RR000163NCRR NIH HHS S10 RR025512NIBIB NIH HHS R25 EB016671NICHD NIH HHS R01 HD086331NIH HHS P51 OD011092NIMH NIH HHS R01 MH107508
Abstract
Purpose To determine whether gadolinium remains in juvenile nonhuman primate tissue after maternal exposure to intravenous gadoteridol during pregnancy. Materials and Methods Gravid rhesus macaques and their offspring (n = 10) were maintained, as approved by the institutional animal care and utilization committee. They were prospectively studied as part of a pre-existing ongoing research protocol to evaluate the effects of maternal malnutrition on placental and fetal development. On gestational days 85 and 135, they underwent placental magnetic resonance imaging after intravenous gadoteridol administration. Amniocentesis was performed on day 135 prior to administration of the second dose of gadoteridol. After delivery, the offspring were followed for 7 months. Tissue samples from eight different organs and from blood were harvested from each juvenile macaque. Gadolinium levels were measured by using inductively coupled plasma mass spectrometry. Results Gadolinium concentration in the amniotic fluid was 0.028 × 10
Indexed as
Maternal ExposureAmniotic FluidAnimalsContrast MediaFemaleGadoliniumHeterocyclic CompoundsMacaca mulattaMagnetic Resonance ImagingOrganometallic CompoundsPregnancyTissue DistributionContrast MediaGadoliniumgadoteridolHeterocyclic CompoundsOrganometallic Compounds
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