Evidence map›Paper›PMID 28872760›Full record

ArticleNeurogastroenterology and motility2018

Relating gastric scintigraphy and symptoms to motility capsule transit and pressure findings in suspected gastroparesis.

W L Hasler, K P May, L A Wilson, M Van Natta, H P Parkman, P J Pasricha, K L Koch, T L Abell, R W McCallum, L A Nguyen and 11 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurogastroenterology and motility, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 85 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Ten controversies in gastroparesis and a look to the future.Neurogastroenterology and motility · 2023
    Review
  9. Article
  10. Review
  11. Progress in Gastroparesis - A Narrative Review of the Work of the Gastroparesis Clinical Research Consortium.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Constipation in Patients With Symptoms of Gastroparesis: Analysis of Symptoms and Gastrointestinal Transit.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022
    Observational
  17. Baseline Predictors of Longitudinal Changes in Symptom Severity and Quality of Life in Patients With Suspected Gastroparesis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022
    Observational
  18. Article
  19. Gastroparesis.Gastroenterology · 2022
    Review
  20. Management of Gastroparesis.Gastroenterology & hepatology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 11 institutions in 1 country.

W L HaslerDivision of Gastroenterology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-6158-2871
K P MayData Coordinating Center, Johns Hopkins University, Baltimore, MD, USA.
L A WilsonData Coordinating Center, Johns Hopkins University, Baltimore, MD, USA.
M Van NattaData Coordinating Center, Johns Hopkins University, Baltimore, MD, USA.
H P ParkmanSection of Gastroenterology, Temple University, Philadelphia, PA, USA.ORCID 0000-0003-4904-4891
P J PasrichaSection of Gastroenterology, Johns Hopkins University, Baltimore, MD, USA.
K L KochSection on Gastroenterology, Wake Forest University, Winston Salem, NC, USA.
T L AbellDivision of Gastroenterology, University of Louisville, Louisville, KY, USA.ORCID 0000-0002-3175-5161
R W McCallumSection of Gastroenterology, Texas Tech University, El Paso, TX, USA.
L A NguyenDivision of Gastroenterology, Stanford University, Palo Alto, CA, USA.
W J SnapeDivision of Gastroenterology, California Pacific Medical Center, San Francisco, CA, USA.
I SarosiekSection of Gastroenterology, Texas Tech University, El Paso, TX, USA.
J O ClarkeDivision of Gastroenterology, Stanford University, Palo Alto, CA, USA.
G FarrugiaSection of Gastroenterology, Mayo Clinic, Rochester, MN, USA.
J Calles-EscandonEndocrinology Section, MetroHealth Medical Center, Cleveland, OH, USA.
M GroverSection of Gastroenterology, Mayo Clinic, Rochester, MN, USA.
J TonasciaData Coordinating Center, Johns Hopkins University, Baltimore, MD, USA.
L A LeeSection of Gastroenterology, Johns Hopkins University Data Coordinating Center, Baltimore, MD, USA.
L MirielData Coordinating Center, Johns Hopkins University, Baltimore, MD, USA.
F A HamiltonNational Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, USA.
NIDDK Gastroparesis Clinical Research Consortium (GpCRC)
Johns Hopkins University · USMayo Clinic · USPalo Alto University · USTexas Tech University · USCalifornia Pacific Medical Center · USMetroHealth · USNational Institute of Diabetes and Digestive and Kidney Diseases · USTemple University · USUniversity of Louisville · USUniversity of Michigan · USWake Forest University · US

Funding

Gastroparesis Consortium Continuation-Data Coordinating CenterU01DK074008 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI TONASCIA, JAMES A · 2006 to 2015
$17.4M
PGpR2 Year 4 Supplement for the Scientific Data Research Center (SDRC) of the GpCRC 4U24DK074008 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI David M Shade · 2017 to 2026
$11.7M
Subtypes of GastroparesisU01DK073974 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Baharak Moshiree · 2006 to 2026
$7.4M
Temple University Gastroparesis Clinical CenterU01DK073975 · NIDDK · TEMPLE UNIV OF THE COMMONWEALTH · PI HENRY PAUL PARKMAN · 2006 to 2026
$7.4M
U of L Clinical Center to Investigate the Pathogenesis, Etiology, and Treatment of Gastroparesis through the NIDDK Gastroparesis ConsortiumU01DK074007 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI Thomas Lyman Abell · 2006 to 2026
$7.0M
Molecular Approaches to Pathogenesis/Therapy in GastropaU01DK073983 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI PANKAJ J PASRICHA · 2006 to 2026
$6.8M
The GpCRC Pediatric Gastroparesis Registry 2 (PGpR2): Characterization and Clinical Course of Symptoms and Gastric Emptying in Pediatric, Adolescent, and Young Adult Participants with Symptoms of GastU01DK074035 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Irene Sarosiek · 2008 to 2026
$6.7M
New England Gastropareis Consortium: Neurobiology of GastroparesisU01DK112193 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Helen Burton Murray, Braden Kuo · 2016 to 2026
$4.8M
Visceral Afferent Dysfunction in Diabetic GastropathyU01DK073985 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HASLER, WILLIAM L · 2006 to 2015
$2.7M
"Barrier function alterations in post-infectious irritable bowel syndrome"K23DK103911 · NIDDK · MAYO CLINIC ROCHESTER · PI GROVER, MADHUSUDAN · 2015 to 2019
$804k
NIDDK NIH HHS K23 DK103911NIDDK NIH HHS U01 DK073974NIDDK NIH HHS U01 DK073975NIDDK NIH HHS U01 DK073983NIDDK NIH HHS U01 DK073985NIDDK NIH HHS U01 DK074007NIDDK NIH HHS U01 DK074008NIDDK NIH HHS U01 DK074035NIDDK NIH HHS U01 DK112193NIDDK NIH HHS U24 DK074008
6 · The paper itself

Abstract

backgroundWireless motility capsule (WMC) findings are incompletely defined in suspected gastroparesis. We aimed to characterize regional WMC transit and contractility in relation to scintigraphy, etiology, and symptoms in patients undergoing gastric emptying testing.

methodsA total of 209 patients with gastroparesis symptoms at NIDDK Gastroparesis Consortium centers underwent gastric scintigraphy and WMCs on separate days to measure regional transit and contractility. Validated questionnaires quantified symptoms. KEY

resultsSolid scintigraphy and liquid scintigraphy were delayed in 68.8% and 34.8% of patients; WMC gastric emptying times (GET) were delayed in 40.3% and showed 52.8% agreement with scintigraphy; 15.5% and 33.5% had delayed small bowel (SBTT) and colon transit (CTT) times. Transit was delayed in ≥2 regions in 23.3%. Rapid transit was rarely observed. Diabetics had slower GET but more rapid SBTT versus idiopathics (P ≤ .02). GET delays related to greater scintigraphic retention, slower SBTT, and fewer gastric contractions (P ≤ .04). Overall gastroparesis symptoms and nausea/vomiting, early satiety/fullness, bloating/distention, and upper abdominal pain subscores showed no relation to WMC transit. Upper and lower abdominal pain scores (P ≤ .03) were greater with increased colon contractions. Constipation correlated with slower CTT and higher colon contractions (P = .03). Diarrhea scores were higher with delayed SBTT and CTT (P ≤ .04). CONCLUSIONS & INFERENCES: Wireless motility capsules define gastric emptying delays similar but not identical to scintigraphy that are more severe in diabetics and relate to reduced gastric contractility. Extragastric transit delays occur in >40% with suspected gastroparesis. Gastroparesis symptoms show little association with WMC profiles, although lower symptoms relate to small bowel or colon abnormalities.

Indexed as

Gastric EmptyingRadionuclide ImagingCapsule EndoscopyFemaleGastroparesisHumansMalePressureProspective Studiescontractilitygastric emptyingscintigraphysmall bowel and colon transit

Identifiers

PMID28872760
PMCPMC6004323
OpenAlexW2750829110

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.