ArticleAddiction biology2019
Neural mechanisms of extinguishing drug and pleasant cue associations in human addiction: role of the VMPFC.
Article in Addiction biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- The influence of sex and reproductive cycle on cocaine-induced behavioral and neurobiological alterations: a review.Experimental brain research · 2022Pooled it
- The brain in social context: A systematic review of substance use and social processing from adolescence to young adulthood.Developmental cognitive neuroscience · 2022Pooled it
- Neuroimaging Impaired Response Inhibition and Salience Attribution in Human Drug Addiction: A Systematic Review.Neuron · 2018Pooled it
- The synergy of methylphenidate- and reconsolidation-based extinction normalizes ventromedial prefrontal function in drug addiction.Proceedings of the National Academy of Sciences of the United States of America · 2025Trial
- Adolescent substance use trajectories are associated with nucleus accumbens functional connectivity.Journal of psychopharmacology (Oxford, England) · 2025Article
- Cocaine Cues Used in Experimental Research: A Systematic Review.Brain sciences · 2025Review
- Enhanced conditioning and disrupted extinction processes in men struggling with compulsive sexual behaviors.Journal of behavioral addictions · 2025Article
- Decoding and modifying dynamic attentional bias in gaming disorder.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Aberrant neural computation of social controllability in nicotine-dependent humans.Communications biology · 2024Article
- Aberrant neural computation of social controllability in nicotine-dependent humans.Research square · 2024Article
- Alterations of interhemispheric functional homotopic connectivity and corpus callosum microstructure in bulimia nervosa.Quantitative imaging in medicine and surgery · 2023Article
- Altered prefrontal signaling during inhibitory control in a salient drug context in cocaine use disorder.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- A systematic review of neural, cognitive, and clinical studies of anger and aggression.Current psychology (New Brunswick, N.J.) · 2022Article
- Temporally dynamic neural correlates of drug cue reactivity, response inhibition, and methamphetamine-related response inhibition in people with methamphetamine use disorder.Scientific reports · 2022Article
- Fear conditioning and extinction in alcohol dependence: Evidence for abnormal amygdala reactivity.Addiction biology · 2021Article
- Amygdala and nucleus accumbens involvement in appetitive extinction.Human brain mapping · 2020Article
- Hypothalamic response to cocaine cues and cocaine addiction severity.Addiction biology · 2020Article
- The emerging neuroscience of appetitive and drug cue extinction in humans.Psychopharmacology · 2019Review
- Role of prefrontal cortex in the extinction of drug memories.Psychopharmacology · 2019Review
- Modeling cocaine relapse in rodents: Behavioral considerations and circuit mechanisms.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
The neurobiological mechanisms that underlie the resistance of drug cue associations to extinction in addiction remain unknown. Fear extinction critically depends on the ventromedial prefrontal cortex (VMPFC). Here, we tested if this same region plays a role in extinction of non-fear, drug and pleasant cue associations. Eighteen chronic cocaine users and 15 matched controls completed three functional MRI scans. Participants first learned to associate an abstract cue (the conditioned stimulus, CS) with a drug-related (CS
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.