Evidence map›Paper›PMID 28872670›Full record

ArticleEuropean journal of immunology2018

TCR-pMHC encounter differentially regulates transcriptomes of tissue-resident CD8 T cells.

Akihiro Yoshizawa, Kevin Bi, Derin B Keskin, Guanglan Zhang, Bruce Reinhold, Ellis L Reinherz

Open access · bronzeAbstract read
In one paragraph

Article in European journal of immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 34 citations in OpenAlex.

  1. CD8MedComm · 2026
    Review
  2. CD27 and ICOS as Targets of PD-1/PD-L1 Signaling to Regulate Resident Memory CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
  13. Influenza-Specific Lung-Resident Memory CD8Cold Spring Harbor perspectives in biology · 2021
    Review
  14. Review
  15. Review
  16. Broad and strong memory CD4Nature immunology · 2020
    Article
  17. Review
  18. Discipline in Stages: Regulating CD8Frontiers in immunology · 2020
    Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Akihiro YoshizawaLaboratory of Immunobiology, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Kevin BiDepartment of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Derin B KeskinLaboratory of Immunobiology, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Guanglan ZhangLaboratory of Immunobiology, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Bruce ReinholdLaboratory of Immunobiology, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Ellis L ReinherzLaboratory of Immunobiology, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1048-5526
Harvard University · USBoston University · USBroad Institute · US

Funding

Crossprotective CTL Against InfluenzaU01AI090043 · NIAID · DANA-FARBER CANCER INST · PI REINHERZ, ELLIS L · 2010 to 2015
$6.4M
Elucidating protective CTL immunity through physical detection of epitopes in conjunction with assessment of TCR-pMHC bond lifetimes under loadR56AI138489 · NIAID · DANA-FARBER CANCER INST · PI REINHERZ, ELLIS L · 2017 to 2017
$450k
NIAID NIH HHS R56 AI138489NIAID NIH HHS U01 AI090043
6 · The paper itself

Abstract

To investigate the role of TCR-pMHC interaction in regulating lung CD8 tissue-resident T cell (T

Indexed as

AnimalsAntigens, CDCD8-Positive T-LymphocytesCell DifferentiationDEAD Box Protein 58Epitopes, T-LymphocyteFemaleImmunologic MemoryInfluenza A Virus, H1N1 SubtypeIntegrin alpha ChainsLungMiceMice, Inbred C57BLNLR ProteinsOrthomyxoviridae InfectionsReceptors, Antigen, T-Cell, alpha-betaalpha E integrinsAntigens, CDDEAD Box Protein 58Epitopes, T-LymphocyteIntegrin alpha ChainsNLR ProteinsReceptors, Antigen, T-Cell, alpha-betaTransforming Growth Factor betaGSEAInfluenza ALung infectionT cellsTCR-pMHCTGF-β, TranscriptomeTRM

Identifiers

PMID28872670
PMCPMC6531858
OpenAlexW2752414371

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.