Evidence map›Paper›PMID 28872637›Full record

Trial reportTranslational psychiatry2017

Mechanisms of cognitive-behavioral therapy for obsessive-compulsive disorder involve robust and extensive increases in brain network connectivity.

T D Moody, F Morfini, G Cheng, C Sheen, R Tadayonnejad, N Reggente, J O'Neill, J D Feusner

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Translational psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

T D MoodyDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
F MorfiniDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
G ChengDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
C SheenDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
R TadayonnejadDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
N ReggenteDepartment of Psychology, University of California Los Angeles, Los Angeles, CA, USA.
J O'NeillDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
J D FeusnerDepartment of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Funding

Anxiety and reward interaction and prediction of outcomes in anorexia nervosaR01MH105662 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE · 2015 to 2019
$2.3M
Cognitive-Behavioral Therapy and Glutamate in Cingulate Gyrus in OCDR01MH085900 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE, O'NEILL, JOSEPH · 2011 to 2014
$1.8M
Understanding the dynamics of visual processing abnormalities in body dysmorphic disorderR21MH110865 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEUSNER, JAMIE · 2017 to 2018
$454k
NIMH NIH HHS R01 MH085900NIMH NIH HHS R01 MH105662NIMH NIH HHS R21 MH110865
6 · The paper itself

Abstract

Cognitive-behavioral therapy (CBT) is effective for obsessive compulsive disorder (OCD); however, little is understood about its mechanisms related to brain network connectivity. We examined connectivity changes from resting-state functional magnetic resonance imaging data pre-to-post-CBT in 43 OCD participants, randomized to receive either 4 weeks of intensive CBT or 4 weeks waitlist followed by 4 weeks of CBT, and 24 healthy controls before and after 4 weeks of no treatment. Network-based-statistic analysis revealed large-magnitude increases in OCD connectivity in eight networks. Strongest increases involved connectivity between the cerebellum and caudate/putamen, and between the cerebellum and dorsolateral/ventrolateral prefrontal cortices. Connectivity increases were associated with increased resistance to compulsions. Mechanisms of CBT may involve enhanced cross-network integration, both within and outside of classical cortico-striatal-thalamo-cortical regions; those involving cerebellar to striatal and prefrontal regions may reflect acquisition of new non-compulsive goal-directed behaviors and thought patterns. Our findings have implications for identifying targets for enhancing treatment efficacy and monitoring treatment progress.

Indexed as

AdultCerebellumCognitive Behavioral TherapyConnectomeFemaleHumansMagnetic Resonance ImagingMaleNeostriatumNerve NetObsessive-Compulsive DisorderOutcome Assessment, Health CarePrefrontal CortexYoung Adult

Identifiers

PMID28872637
PMCPMC5639240

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.