Evidence map›Paper›PMID 28872625›Full record

ArticleInternational journal of molecular sciences2017

Salivary Gland Derived BDNF Overexpression in Mice Exerts an Anxiolytic Effect.

Juri Saruta, Masahiro To, Masahiro Sugimoto, Yuko Yamamoto, Tomoko Shimizu, Yusuke Nakagawa, Hiroko Inoue, Ichiro Saito, Keiichi Tsukinoki

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Juri SarutaDepartment of Oral Science, Graduate School of Dentistry, Kanagawa Dental University, 82 Inaoka, Yokosuka, Kanagawa 238-8580, Japan. saruta@kdu.ac.jp.
Masahiro ToDepartment of Oral Science, Graduate School of Dentistry, Kanagawa Dental University, 82 Inaoka, Yokosuka, Kanagawa 238-8580, Japan. m.tou@kdu.ac.jp.
Masahiro SugimotoDepartment of Oral Science, Graduate School of Dentistry, Kanagawa Dental University, 82 Inaoka, Yokosuka, Kanagawa 238-8580, Japan. msugi@sfc.keio.ac.jp.
Yuko YamamotoSchool of Dental Hygiene, Department of Junior College, Kanagawa Dental University, Yokosuka, Kanagawa 238-8580, Japan. yuko@yd6.so-net.ne.jp.
Tomoko ShimizuDepartment of Highly Advanced Stomatology, Yokohama, Kanagawa Dental University, Graduate School of Dentistry, Yokohama, Kanagawa 221-0835, Japan. shimizu@kdu.ac.jp.
Yusuke NakagawaDepartment of Oral Science, Graduate School of Dentistry, Kanagawa Dental University, 82 Inaoka, Yokosuka, Kanagawa 238-8580, Japan. yusuke_2828@yahoo.co.jp.
Hiroko InoueDepartment of Pathology, Tsurumi University School of Dental Medicine, Yokohama, Kanagawa 238-8580, Japan. inoue-h@nichiyaku.ac.jp.
Ichiro SaitoDepartment of Pathology, Tsurumi University School of Dental Medicine, Yokohama, Kanagawa 238-8580, Japan. saito-i@tsurumi-u.ac.jp.
Keiichi TsukinokiDepartment of Oral Science, Graduate School of Dentistry, Kanagawa Dental University, 82 Inaoka, Yokosuka, Kanagawa 238-8580, Japan. tsukinoki@kdu.ac.jp.
Kanagawa Dental University · JPTsurumi University · JPTokyo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain-derived neurotrophic factor (BDNF) is abundant in the hippocampus and plays critical roles in memory and synapse formation, as well as exerting antidepressant-like effects in psychiatric disorders. We previously reported that BDNF is expressed in salivary glands and affects blood BDNF content. However, the function of salivary BDNF remains unclear. The aim of this study was to generate transgenic mice overexpressing BDNF in the salivary glands. Hence, we used the Lama construct (hemagglutinin (HA)-tagged mouse

Indexed as

AnimalsAnti-Anxiety AgentsBrain-Derived Neurotrophic Factorgamma-Aminobutyric AcidGlutamate DecarboxylaseHippocampusMiceMice, TransgenicProtein-Tyrosine KinasesSalivary GlandsAnti-Anxiety AgentsBrain-Derived Neurotrophic Factorgamma-Aminobutyric AcidGlutamate Decarboxylaseglutamate decarboxylase 1Protein-Tyrosine KinasesanxiolyticBDNFhippocampussalivasalivary glandtransgenic mouseTrkB

Identifiers

PMID28872625
PMCPMC5618551
OpenAlexW2753099223

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.