ArticleAmerican journal of respiratory and critical care medicine2018
Quantitative Evidence for Revising the Definition of Primary Graft Dysfunction after Lung Transplant.
Article in American journal of respiratory and critical care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Effect of targeted coagulopathy management and 5% albumin as volume replacement therapy during lung transplantation on allograft function: a secondary analysis of a randomized clinical trial.BMC pulmonary medicine · 2023Trial
- Utility of donor-derived cell-free DNA testing after lung transplantation in the precision medicine era.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026Review
- Association between intraoperative fluid volume and 30-day mortality in patients undergoing lung transplantation: a retrospective cohort study.Journal of thoracic disease · 2026Article
- The NHLBI lung transplant consortium 2025 steering committee report: Strategies to maximize the use of the consortium for advancing lung transplantation.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2026Article
- Prolonged Invasive Mechanical Ventilation is Associated With Decreased Survival After Lung Transplantation Among Recipients With Primary Graft Dysfunction: A Lung Transplant Outcomes Group Study.Clinical transplantation · 2026Article
- Impact of preoperative left ventricular diastolic dysfunction on primary graft dysfunction and mortality following lung transplantation.Journal of thoracic disease · 2025Article
- Long-term outcomes of the international EXPAND trial of Organ Care System (OCS) Lung preservation for lung transplantation.EClinicalMedicine · 2025Article
- Lung allograft dysbiosis associates with immune response and primary graft dysfunction.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025Article
- Primary graft dysfunction after Lung transplantation: unveiling the role of innate immunity.Clinical and experimental immunology · 2025Article
- The comparative impact of central vs. peripheral VA-ECMO cannulation on postoperative graft dysfunction in lung transplantation: a retrospective analysis.Frontiers in cardiovascular medicine · 2025Article
- Airway epithelium in lung transplantation: a potential actor for post-transplant complications?European respiratory review : an official journal of the European Respiratory Society · 2024Review
- Ex Vivo Lung Perfusion and Primary Graft Dysfunction Following Lung Transplantation: A Contemporary United Network for Organ Sharing Database Analysis.Journal of clinical medicine · 2024Article
- Early serum biomarkers to characterise different phenotypes of primary graft dysfunction after lung transplantation: a systematic scoping review.ERJ open research · 2024Article
- Scoring donor lungs for graft failure risk: The Lung Donor Risk Index (LDRI).American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2024Article
- Development and validation of primary graft dysfunction predictive algorithm for lung transplant candidates.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024Article
- Primary graft dysfunction in lung transplantation: still a thorn in the side of lung transplant.Journal of thoracic disease · 2024Article
- The Impact of Donor Smoking on Primary Graft Dysfunction and Mortality after Lung Transplantation.American journal of respiratory and critical care medicine · 2024Article
- Contemporary trends in PGD incidence, outcomes, and therapies.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2022Article
- Article
- Plasma protein biomarkers for primary graft dysfunction after lung transplantation: a single-center cohort analysis.Scientific reports · 2022Article
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Authors and funding
30 authors.
Funding
Abstract
rationalePrimary graft dysfunction (PGD) is a form of acute lung injury that occurs after lung transplantation. The definition of PGD was standardized in 2005. Since that time, clinical practice has evolved, and this definition is increasingly used as a primary endpoint for clinical trials; therefore, validation is warranted.
objectivesWe sought to determine whether refinements to the 2005 consensus definition could further improve construct validity.
methodsData from the Lung Transplant Outcomes Group multicenter cohort were used to compare variations on the PGD definition, including alternate oxygenation thresholds, inclusion of additional severity groups, and effects of procedure type and mechanical ventilation. Convergent and divergent validity were compared for mortality prediction and concurrent lung injury biomarker discrimination. MEASUREMENTS AND MAIN
resultsA total of 1,179 subjects from 10 centers were enrolled from 2007 to 2012. Median length of follow-up was 4 years (interquartile range = 2.4-5.9). No mortality differences were noted between no PGD (grade 0) and mild PGD (grade 1). Significantly better mortality discrimination was evident for all definitions using later time points (48, 72, or 48-72 hours; P < 0.001). Biomarker divergent discrimination was superior when collapsing grades 0 and 1. Additional severity grades, use of mechanical ventilation, and transplant procedure type had minimal or no effect on mortality or biomarker discrimination.
conclusionsThe PGD consensus definition can be simplified by combining lower PGD grades. Construct validity of grading was present regardless of transplant procedure type or use of mechanical ventilation. Additional severity categories had minimal impact on mortality or biomarker discrimination.
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