Evidence map›Paper›PMID 28872259›Full record

Trial reportEuropean journal of heart failure2018

Prevalence and prognostic importance of precipitating factors leading to heart failure hospitalization: recurrent hospitalizations and mortality.

Elke Platz, Pardeep S Jhund, Brian L Claggett, Marc A Pfeffer, Karl Swedberg, Christopher B Granger, Salim Yusuf, Scott D Solomon, John J McMurray

2 registry-linked trialsOpen access · bronzeAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of heart failure, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 38 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 4 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05567445 unknown statusnot on this mapstarted 2023, after this paper: background citation

Characteristics and Outcomes of Heart Failure-Related Intensive Care Unit Admissions in Adults With Cardiomyopathy.

Typeobservational_patient_registrySponsorAssiut UniversityRan2023 to 2024Enrolled45ConditionsCardiomyopathiesArmsEchocardiography, CBC, Liver function, kideny function
NCT05588375 naunknown statusnot on this mapstarted 2022, after this paper: background citation

The Effects of Home-based Physical Activity Telemonitoring Program in Patients With Heart Failure and Muscle Wasting in the Post-epidemic Era

TypeinterventionalSponsorFar Eastern Memorial HospitalRan2022 to 2023Enrolled118ConditionsSarcopenia, Muscular Atrophy, Wasting Syndrome, Heart FailureArmshome-based physical activity telemonitoring program
3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 91 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Highlights in heart failure.ESC heart failure · 2019
    Pooled it
  5. Trial
  6. Trial
  7. An integrated overview of acute heart failure: a narrative review of pathophysiological mechanisms and contributing factors.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026
    Review
  8. Article
  9. Article
  10. Observational
  11. Review
  12. Review
  13. Article
  14. Prognostic Models in Heart Failure: Hope or Hype?Journal of personalized medicine · 2025
    Review
  15. Article
  16. Article
  17. Observational
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Elke PlatzDepartment of Emergency Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Pardeep S JhundBritish Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Brian L ClaggettCardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Marc A PfefferCardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Karl SwedbergDepartment of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.
Christopher B GrangerDivision of Cardiology, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Salim YusufPopulation Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, ON, Canada.
Scott D SolomonCardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
John J McMurrayBritish Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
Harvard University · USBritish Heart Foundation · GBDuke Medical Center · USImperial College London · GBMcMaster University · CAUniversity of Glasgow · GB

Funding

Utility of Lung Ultrasound in Assessing Pulmonary Congestion in Heart FailureK23HL123533 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI PLATZ, ELKE · 2015 to 2019
$881k
NHLBI NIH HHS K23 HL123533
6 · The paper itself

Abstract

aimsHospitalizations for heart failure (HF) are common and are associated with significant morbidity, mortality and cost. However, precipitating factors leading to HF hospitalization and their importance with respect to subsequent outcomes are not well understood. METHODS AND

resultsThe symptoms and signs present at admission and investigator-identified factors thought to have contributed to the first adjudicated HF hospitalization in the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) programme were prospectively collected and stratified by ejection fraction (EF). Potential precipitants were collected using a specifically designed case report form and categorized according to the presence of cardiovascular (CV), non-CV and unknown factors. Associations between these factors and subsequent rehospitalization and mortality rates were examined. Of 1668 patients who experienced HF hospitalization, 1152 had reduced EF (≤40%, HFrEF) and 516 had preserved EF (HFpEF). Overall, 54% had CV, 32% had non-CV and 14% had unknown factors thought to have precipitated HF, with similar proportions in the HFrEF and HFpEF groups. The most common precipitants were arrhythmia (15%), other non-CV factors (11%) and respiratory infection (10%). Subsequent CV readmission rates were highest in those whose initial HF hospitalization was precipitated by CV factors. However, mortality rates were similar among patients with any of the three categories of precipitating factors. Results were similar in HFrEF and HFpEF.

conclusionsAmong chronic HF patients hospitalized for decompensation, the investigator-reported precipitating factor was not associated with the subsequent mortality rate, but was associated with type of readmission: readmissions for CV reasons were more likely when the index precipitant was CV.

Indexed as

Risk AssessmentAgedFemaleHeart FailureHospitalizationHumansMaleMorbidityOntarioPatient ReadmissionPrecipitating FactorsPrevalencePrognosisStroke VolumeSurvival RateUnited KingdomEjection fractionHeart failureHospitalizationPrecipitating factorsPrognosis

Identifiers

PMID28872259
PMCPMC5826811
OpenAlexW2613695111

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.