Evidence map›Paper›PMID 28872108›Full record

ArticleJournal of visualized experiments : JoVE2017

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4.

Sharon A Sagan, Andrés Cruz-Herranz, Collin M Spencer, Peggy P Ho, Lawrence Steinman, Ari J Green, Raymond A Sobel, Scott S Zamvil

Open access · greenAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of visualized experiments : JoVE, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  4. Pain Symptoms in Optic Neuritis.Frontiers in pain research (Lausanne, Switzerland) · 2022
    Review
  5. Article
  6. Article
  7. The Gut Microbiome in Neuromyelitis Optica.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Sharon A SaganDepartment of Neurology, University of California; Program in Immunology, University of California.
Andrés Cruz-HerranzDepartment of Neurology, University of California.
Collin M SpencerDepartment of Neurology, University of California; Program in Immunology, University of California.
Peggy P HoDepartment of Neurology and Neurological Sciences, Stanford University.
Lawrence SteinmanDepartment of Neurology and Neurological Sciences, Stanford University.
Ari J GreenDepartment of Neurology, University of California.
Raymond A SobelDepartment of Pathology, Stanford University.
Scott S ZamvilDepartment of Neurology, University of California; Program in Immunology, University of California; zamvil@ucsf.neuroimmunol.org.
Stanford University · USUniversity of California System · US

Funding

B cells in CNS autoimmunityR01AI073737 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ZAMVIL, SCOTT S · 2009 to 2013
$1.9M
Disease relevance of CD20 expression on T cells in multiple sclerosis patientsR01NS092835 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAUSER, STEPHEN L · 2015 to 2018
$1.7M
NIAID NIH HHS R01 AI073737NINDS NIH HHS R01 NS092835
6 · The paper itself

Abstract

While it is recognized that aquaporin-4 (AQP4)-specific T cells and antibodies participate in the pathogenesis of neuromyelitis optica (NMO), a human central nervous system (CNS) autoimmune demyelinating disease, creation of an AQP4-targeted model with both clinical and histologic manifestations of CNS autoimmunity has proven challenging. Immunization of wild-type (WT) mice with AQP4 peptides elicited T cell proliferation, although those T cells could not transfer disease to naïve recipient mice. Recently, two novel AQP4 T cell epitopes, peptide (p) 135-153 and p201-220, were identified when studying immune responses to AQP4 in AQP4-deficient (AQP4

Indexed as

AnimalsAquaporin 4AutoantigensHumansMiceNeuromyelitis OpticaOptic NerveParalysisT-LymphocytesAquaporin 4Autoantigens

Identifiers

PMID28872108
PMCPMC5614352
OpenAlexW2746854592

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.