Evidence map›Paper›PMID 28871344›Full record

ArticleCancer causes & control : CCC2017

Tubal ligation and ovarian cancer risk in African American women.

Chrissy McNamara, Sarah E Abbott, Elisa V Bandera, Bo Qin, Lauren C Peres, Fabian Camacho, Patricia G Moorman, Anthony J Alberg, Jill S Barnholtz-Sloan, Melissa Bondy and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer causes & control : CCC, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 13 institutions in 1 country.

Chrissy McNamaraGeorgia Comprehensive Cancer Registry, Georgia Department of Public Health, Atlanta, GA, USA.
Sarah E AbbottDepartment of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Elisa V BanderaDepartment of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Bo QinDepartment of Population Science, Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Lauren C PeresDepartment of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Fabian CamachoDepartment of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Patricia G MoormanDepartment of Community and Family Medicine, Duke Cancer Institute, Durham, NC, USA.
Anthony J AlbergHollings Cancer Center and Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, USA.
Jill S Barnholtz-SloanCase Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Melissa BondyCancer Prevention and Population Sciences Program, Baylor College of Medicine, Houston, TX, USA.
Michele L CoteDepartment of Oncology and the Karmanos Cancer Institute, Population Studies and Disparities Research Program, Wayne State University School of Medicine, Detroit, MI, USA.
Ellen FunkhouserDivision of Preventive Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Edward S PetersEpidemiology Program, Louisiana State University Health Sciences Center School of Public Health, New Orleans, LA, USA.
Ann G SchwartzDepartment of Oncology and the Karmanos Cancer Institute, Population Studies and Disparities Research Program, Wayne State University School of Medicine, Detroit, MI, USA.
Joellen M SchildkrautDepartment of Public Health Sciences, University of Virginia, Charlottesville, VA, USA.
Paul TerryDepartment of Medicine, The University of Tennessee Graduate School of Medicine, 1924 Alcoa Highway Box U-114, Knoxville, TN, 37920, USA. pterry@utmck.edu.
University of Virginia · USBaylor College of Medicine · USCase Western Reserve University · USDuke Medical Center · USGeorgia Department of Public Health · USLouisiana State University Health Sciences Center New Orleans · USMUSC Hollings Cancer Center · USRutgers Cancer Institute of New JerseyRutgers, The State University of New Jersey · USThe Barbara Ann Karmanos Cancer Institute · USUniversity of Alabama at Birmingham · USUniversity of Tennessee at Knoxville · USWayne State University · US

Funding

TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Tracie Saunders · 1997 to 2026
$94.5M
Tumor Biology and Microenvironment (Program 1)P30CA022453 · NCI · WAYNE STATE UNIVERSITY · PI Julie Lynn Boerner · 1985 to 2026
$68.4M
NEW JERSEY CANCER PREVENTION & CONTROL PROGRAMU58DP003931 · DP · NEW JERSEY STATE DEPT/HEALTH/SENIOR SRVS · PI RODRIQUEZ, GLORIA · 2012 to 2014
$11.9M
Epidemiology of Ovarian Cancer in African-American WomenR01CA142081 · NCI · UNIVERSITY OF VIRGINIA · PI SCHILDKRAUT, JOELLEN M. · 2010 to 2015
$10.6M
NCCDPHP CDC HHS U58 DP003931NCI NIH HHS 1 R01 CA142081-01A1NCI NIH HHS HHSN261201000028CNCI NIH HHS HHSN261201300021CNCI NIH HHS P30 CA022453NCI NIH HHS P30 CA072720NCI NIH HHS R01 CA142081
6 · The paper itself

Abstract

purposeTubal ligation has been associated with reduced risk of epithelial ovarian cancer (EOC) in studies of primarily white women, but less is known about the association in African American (AA) women. We sought to evaluate the associations among 597 invasive ovarian cancer cases and 742 controls of AA descent recruited from the African American Cancer Epidemiology Study, a population-based case-control study in 11 geographical areas in the US.

methodsMultivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) adjusted for potentially confounding factors.

resultsAn inverse association between tubal ligation and EOC was observed that was not statistically significant (OR 0.88, 95% CI 0.68-1.14). However, an inverse association with EOC risk was observed among women who had a tubal ligation at age 35 years or older (OR 0.64; 95% CI 0.41-0.98), but not among those who had a tubal ligation before age 35 (OR 0.98; 95% CI 0.74-1.29) (p for interaction = 0.08). The association also varied considerably by tumor subtype. A strong inverse association was observed for endometrioid tumors (OR 0.31, 95% CI 0.14-0.70), whereas associations with mucinous (OR 0.87, 95% CI 0.36-2.12) and serous (OR 0.94, 95% CI 0.71-1.24) tumors were weaker and not statistically significant. A statistically non-significant positive association for clear cell tumors (OR 1.84, 95% CI 0.58-5.82) was based on a low number of cases.

conclusionsOur findings show that tubal ligation may confer a reduced risk for EOC among AA women that is comparable to the associations that have been previously observed in primarily white populations.

Indexed as

Sterilization, TubalAdultAgedBlack or African AmericanCase-Control StudiesFemaleHumansLogistic ModelsMiddle AgedOdds RatioOvarian NeoplasmsRisk FactorsUnited StatesYoung AdultAfrican-American womenEpidemiologic studiesOvarian cancerTubal ligation

Identifiers

PMID28871344
PMCPMC6785827
OpenAlexW2753037558

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.